Details for: CL0000646

Cell ID: CL0000646

Cell Name: basal cell

Marker Score Threshold: 1291
(Derived using integrated single-cell and genomic data)

Description: Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.4
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.33
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.27
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.13
    Ensembl ID: ENSG00000135046
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.61
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.57
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.48
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.46
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.42
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.35
    Ensembl ID: ENSG00000069849
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.26
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 2.16
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.14
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.1
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.09
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.06
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.03
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.99
    Ensembl ID: ENSG00000165092
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.93
    Ensembl ID: ENSG00000115963
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.88
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.87
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.87
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.85
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.82
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.81
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.78
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165272
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.68
    Ensembl ID: ENSG00000100852
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.68
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.67
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.67
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.66
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.63
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.62
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.61
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 1.59
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.59
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.56
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.56
    Ensembl ID: ENSG00000124172
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.55
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.54
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.53
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.53
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.52
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.51
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.51
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.47
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.47
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.43
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.43
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.42
    Ensembl ID: ENSG00000164904
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.42
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.37
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.36
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.36
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.35
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.34
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.32
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.31
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.3
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.29
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.27
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.27
    Ensembl ID: ENSG00000131100
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.23
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.22
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.22
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.21
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.17
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100412
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143799
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.15
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.13
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.13
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.13
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.13
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.12
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.11
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.1
    Ensembl ID: ENSG00000110330
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.08
    Ensembl ID: ENSG00000171552
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.08
    Ensembl ID: ENSG00000002330
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.08
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.06
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.06
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.02
    Ensembl ID: ENSG00000117054
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.02
    Ensembl ID: ENSG00000166747
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.02
    Ensembl ID: ENSG00000162688
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.01
    Ensembl ID: ENSG00000169252
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.01
    Ensembl ID: ENSG00000156273
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Undifferentiated**: Basal cells are undifferentiated, meaning they have not yet undergone significant specialization to form a specific cell type. 2. **Mitotic stem cells**: Basal cells are mitotic stem cells, meaning they have the ability to divide and differentiate into other cell types. 3. **Rounded or elliptical shape**: Basal cells are typically rounded or elliptical in shape, with minimal cytoplasm and few organelles. 4. **Cytokeratin intermediate filaments**: Basal cells contain cytokeratin intermediate filaments, which provide structural support and maintain cell shape. 5. **Involvement in cellular processes**: Basal cells are involved in various cellular processes, including cell-cell communication, cell-extracellular matrix interactions, and regulation of cell cycle. **Clinical Significance** 1. **Infectious diseases**: Basal cells are implicated in the development of various infectious diseases, including viral infections, bacterial infections, and parasitic infections. 2. **Cancer**: Basal cells are thought to contribute to the development of various types of cancer, including skin cancer, lung cancer, and breast cancer. 3. **Autoimmune disorders**: Basal cells are implicated in the development of autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 4. **Regulation of cell cycle**: Basal cells play a role in regulating the cell cycle, which is essential for maintaining tissue homeostasis and preventing cancer. 5. **Development of epithelial tissues**: Basal cells are involved in the development of epithelial tissues, including skin, lung, and gut epithelium. **Gene Expression and Pathways** Basal cells express a range of genes involved in cellular processes, including: 1. **Actin cytoskeleton**: Basal cells express genes involved in actin cytoskeleton formation, including ACTB, which is a critical component of the actin cytoskeleton. 2. **Adherens junctions**: Basal cells express genes involved in adherens junctions, including E-cadherin and β-catenin, which are essential for cell-cell adhesion. 3. **Apoptosis**: Basal cells express genes involved in apoptosis, including BAX and BCL2, which regulate programmed cell death. 4. **Immune system**: Basal cells express genes involved in the immune system, including MHC class I and II, which are essential for antigen presentation and immune response. Overall, basal cells play a critical role in maintaining tissue homeostasis and preventing disease. Understanding the molecular mechanisms underlying basal cell biology is essential for developing effective treatments for various diseases.