Details for: CL0000648

Cell ID: CL0000648

Cell Name: kidney granular cell

Description: A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation.

Synonyms: juxtaglomerular cell, JG cell, renin secreting cell

Genes (max top 100)

(Fold Change: Indicates the ratio of the CSI Threshold for kidney granular cell to Cell Significance Index of kidney granular cell in specific gene. A fold change greater than 1 suggests significant gene expression.)

  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: N/A
    Ensembl ID: ENSG00000121410
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: N/A
    Ensembl ID: ENSG00000175899
  • Gene Symbol: A2MP1 (ENSG00000291190)
    Fold Change: N/A
    Ensembl ID: ENSG00000291190
  • Gene Symbol: NAT1 (ENSG00000171428)
    Fold Change: N/A
    Ensembl ID: ENSG00000171428
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: N/A
    Ensembl ID: ENSG00000156006
  • Gene Symbol: NATP (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: N/A
    Ensembl ID: ENSG00000196136
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: N/A
    Ensembl ID: ENSG00000114771
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: N/A
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: N/A
    Ensembl ID: ENSG00000129673
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: N/A
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AAVS1 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: N/A
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: N/A
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: N/A
    Ensembl ID: ENSG00000107331
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: N/A
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: N/A
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: N/A
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: N/A
    Ensembl ID: ENSG00000198691
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: N/A
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: N/A
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: N/A
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: N/A
    Ensembl ID: ENSG00000175164
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: N/A
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: N/A
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: N/A
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: N/A
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: N/A
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: N/A
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: N/A
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: N/A
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: N/A
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: N/A
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: N/A
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: N/A
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: N/A
    Ensembl ID: ENSG00000110881
  • Gene Symbol: ACHE (ENSG00000087085)
    Fold Change: N/A
    Ensembl ID: ENSG00000087085
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: N/A
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: N/A
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ACR (ENSG00000100312)
    Fold Change: N/A
    Ensembl ID: ENSG00000100312
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: N/A
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: N/A
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: N/A
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACP2 (ENSG00000134575)
    Fold Change: N/A
    Ensembl ID: ENSG00000134575
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: N/A
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: N/A
    Ensembl ID: ENSG00000014257
  • Gene Symbol: ACRV1 (ENSG00000134940)
    Fold Change: N/A
    Ensembl ID: ENSG00000134940
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: N/A
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: N/A
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: N/A
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTBP2 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP3 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP4 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP6 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP7 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP8 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP9 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: N/A
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: N/A
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: N/A
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ACTG1P1 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P2 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P3 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: N/A
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACTG1P9 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P10 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: N/A
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: N/A
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: N/A
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: N/A
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: N/A
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: N/A
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: N/A
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACVR2B (ENSG00000114739)
    Fold Change: N/A
    Ensembl ID: ENSG00000114739
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: N/A
    Ensembl ID: ENSG00000139567
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: N/A
    Ensembl ID: ENSG00000243989
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: N/A
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: N/A
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: N/A
    Ensembl ID: ENSG00000196839
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: N/A
    Ensembl ID: ENSG00000151651
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: N/A
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: N/A
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: N/A
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: N/A
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: N/A
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: N/A
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: N/A
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: N/A
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: N/A
    Ensembl ID: ENSG00000174233
  • Gene Symbol: ADCY7 (ENSG00000121281)
    Fold Change: N/A
    Ensembl ID: ENSG00000121281
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: N/A
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: N/A
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ADCYAP1 (ENSG00000141433)
    Fold Change: N/A
    Ensembl ID: ENSG00000141433
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: N/A
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: N/A
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: N/A
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: N/A
    Ensembl ID: ENSG00000148700
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: N/A
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: N/A
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: N/A
    Ensembl ID: ENSG00000196616

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the CSI Threshold for kidney granular cell to Cell Significance Index of kidney granular cell in specific gene. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the CSI Threshold for kidney granular cell to Cell Significance Index of kidney granular cell in specific gene. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Location: Wall of the afferent arteriole at the entrance to the glomerulus * Cell type: Smooth muscle cell * Function: Synthesizes, stores, and secretes renin * Expression: Smooth muscle actin upon maturation * Synonyms: Juxtaglomerular cell, JG cell, Renin-secreting cell * Gene symbols: RPL13, RPLP1, ACTB * Pathways/ontology: Axon guidance, Blastocyst development, Bone development, Cap-dependent translation initiation, Cellular responses to stimuli, Cellular responses to stress, Cellular response to starvation, Cytoplasm, Cytoplasmic translation, Cytosol, Cytosolic large ribosomal subunit, Cytosolic ribosome, Developmental biology, Disease, Endoplasmic reticulum, Eukaryotic translation elongation, Eukaryotic translation initiation, Eukaryotic translation termination, Formation of a pool of free 40s subunits, GTP hydrolysis and joining of the 60s ribosomal subunit, Infectious disease, Influenza infection, Influenza viral RNA transcription and replication, L13a-mediated translational silencing of ceruloplasmin expression, Major pathway of RNA processing in the nucleolus and cytosol, Membrane, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Metabolism of RNA, Nervous system development, Nonsense-mediated decay (nmd), Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc), Nonsense mediated decay (nmd) independent of the exon junction complex (ejc), Nucleolus, Nucleus, Peptide chain elongation, Protein binding, Regulation of expression of slits and robos, Response of eIF2AK4 (Gcn2) to amino acid deficiency, RNA binding, RNA processing, RNA processing in the nucleus and cytosol, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by robo receptors, Srp-dependent cotranslational protein targeting to membrane, Structural constituent of ribosome, Synapse, Translation, Viral infection pathways, Viral mRNA translation **Clinical Significance** The kidney granular cell plays a crucial role in regulating blood pressure and electrolyte balance. Dysregulation of the RAAS pathway, including the secretion of renin by kidney granular cells, has been implicated in various pathological conditions, including: * Hypertension: Elevated renin secretion by kidney granular cells can lead to increased blood pressure and cardiovascular disease. * Kidney disease: Dysregulation of the RAAS pathway can contribute to kidney damage and fibrosis. * Cardiovascular disease: The RAAS pathway is involved in the development of cardiovascular disease, including heart failure and atherosclerosis. * Renal fibrosis: The RAAS pathway can contribute to the development of renal fibrosis, a common complication of kidney disease. Understanding the function and regulation of the kidney granular cell is essential for the development of novel therapeutic strategies for the treatment of these diseases.