Details for: CL0000650

Cell ID: CL0000650

Cell Name: mesangial cell

Marker Score Threshold: 1207
(Derived using integrated single-cell and genomic data)

Description: A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries.

Synonyms: kidney mesangial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.21
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CLPS (ENSG00000137392)
    Fold Change: 2.98
    Ensembl ID: ENSG00000137392
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.66
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.62
    Ensembl ID: ENSG00000070961
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.47
    Ensembl ID: ENSG00000053254
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.46
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.43
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CEL (ENSG00000170835)
    Fold Change: 2.28
    Ensembl ID: ENSG00000170835
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.19
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.17
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.08
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.06
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.04
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.98
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CENPF (ENSG00000117724)
    Fold Change: 1.95
    Ensembl ID: ENSG00000117724
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.95
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CDH7 (ENSG00000081138)
    Fold Change: 1.94
    Ensembl ID: ENSG00000081138
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.9
    Ensembl ID: ENSG00000135404
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.89
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.89
    Ensembl ID: ENSG00000146950
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.86
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.84
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.76
    Ensembl ID: ENSG00000170017
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.76
    Ensembl ID: ENSG00000145741
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.76
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.75
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CDH10 (ENSG00000040731)
    Fold Change: 1.75
    Ensembl ID: ENSG00000040731
  • Gene Symbol: CNTFR (ENSG00000122756)
    Fold Change: 1.75
    Ensembl ID: ENSG00000122756
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.69
    Ensembl ID: ENSG00000105810
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: 1.68
    Ensembl ID: ENSG00000181072
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.68
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.66
    Ensembl ID: ENSG00000141367
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.62
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.62
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.61
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.59
    Ensembl ID: ENSG00000160710
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.57
    Ensembl ID: ENSG00000164919
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.55
    Ensembl ID: ENSG00000142192
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.55
    Ensembl ID: ENSG00000131143
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.52
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.49
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.48
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.47
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.47
    Ensembl ID: ENSG00000148700
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.44
    Ensembl ID: ENSG00000138760
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.44
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.43
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.4
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.35
    Ensembl ID: ENSG00000153113
  • Gene Symbol: COL8A1 (ENSG00000144810)
    Fold Change: 1.35
    Ensembl ID: ENSG00000144810
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.35
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.34
    Ensembl ID: ENSG00000122705
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.34
    Ensembl ID: ENSG00000126267
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.34
    Ensembl ID: ENSG00000134982
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.3
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.3
    Ensembl ID: ENSG00000113273
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.3
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.29
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.29
    Ensembl ID: ENSG00000153956
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.28
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.26
    Ensembl ID: ENSG00000058668
  • Gene Symbol: BARD1 (ENSG00000138376)
    Fold Change: 1.25
    Ensembl ID: ENSG00000138376
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.25
    Ensembl ID: ENSG00000079102
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.23
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BMP2 (ENSG00000125845)
    Fold Change: 1.23
    Ensembl ID: ENSG00000125845
  • Gene Symbol: BMP1 (ENSG00000168487)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168487
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.21
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.21
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.17
    Ensembl ID: ENSG00000198898
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149823
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CNN2 (ENSG00000064666)
    Fold Change: 1.15
    Ensembl ID: ENSG00000064666
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.14
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.13
    Ensembl ID: ENSG00000111642
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.13
    Ensembl ID: ENSG00000034053
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.11
    Ensembl ID: ENSG00000153922
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.11
    Ensembl ID: ENSG00000107779
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.11
    Ensembl ID: ENSG00000060982
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.1
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138696
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.07
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.07
    Ensembl ID: ENSG00000128595
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.05
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.03
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.02
    Ensembl ID: ENSG00000171791
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.02
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.02
    Ensembl ID: ENSG00000082258
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 1.01
    Ensembl ID: ENSG00000140945
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196961
  • Gene Symbol: SLC31A1 (ENSG00000136868)
    Fold Change: 1
    Ensembl ID: ENSG00000136868
Hovered Details

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Hovered Details

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**Key Characteristics** Mesangial cells are characterized by their unique structure and function. They are found in the glomeruli, where they surround the capillaries and venules, and are responsible for: 1. **Encapsulation**: Mesangial cells encapsulate the capillaries and venules, providing a framework for the filtration of blood. 2. **Matrix secretion**: Mesangial cells secrete a matrix that provides structural support to the capillaries. 3. **Cell-cell interactions**: Mesangial cells interact with other cells in the glomeruli, including podocytes and endothelial cells. 4. **Response to stimuli**: Mesangial cells respond to various stimuli, including changes in blood flow and pressure. **Clinical Significance** Mesangial cells play a crucial role in the maintenance of renal function. Dysfunction or damage to mesangial cells can lead to various kidney diseases, including: 1. **Glomerulonephritis**: Mesangial cells can be involved in the development of glomerulonephritis, a disease characterized by inflammation and damage to the glomeruli. 2. **Nephrotic syndrome**: Mesangial cells can be involved in the development of nephrotic syndrome, a disease characterized by excessive loss of protein in the urine. 3. **Diabetic nephropathy**: Mesangial cells can be involved in the development of diabetic nephropathy, a disease characterized by damage to the kidneys due to high blood sugar levels. **Pathways/Ontology** Mesangial cells are involved in various signaling pathways and ontologies, including: 1. **Actin cytoskeleton**: Mesangial cells are involved in the regulation of the actin cytoskeleton, which is essential for cell motility and division. 2. **Apical junction complex**: Mesangial cells are involved in the formation and maintenance of apical junction complexes, which are essential for cell-cell interactions. 3. **Chromatin remodeling**: Mesangial cells are involved in chromatin remodeling, which is essential for gene expression and regulation. 4. **Signaling by rho gtpases**: Mesangial cells are involved in signaling by rho gtpases, which are essential for cell motility and division. In conclusion, mesangial cells play a crucial role in the maintenance of renal function and are involved in various signaling pathways and ontologies. Dysfunction or damage to mesangial cells can lead to various kidney diseases, highlighting the importance of understanding the biology and function of these cells.