Details for: CL0000651

Cell ID: CL0000651

Cell Name: mucous neck cell

Marker Score Threshold: 2269
(Derived using integrated single-cell and genomic data)

Description: A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands

Synonyms: neck cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.6
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.47
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.37
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.32
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.28
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.24
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.18
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 3.11
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.96
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 2.79
    Ensembl ID: ENSG00000248144
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.78
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.75
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.7
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.67
    Ensembl ID: ENSG00000172270
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 2.54
    Ensembl ID: ENSG00000102554
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.52
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.51
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.49
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.48
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.45
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.45
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.44
    Ensembl ID: ENSG00000168374
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.41
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.4
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2.35
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.3
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.29
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.27
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.27
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.26
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.23
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.19
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 2.1
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.06
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 2.05
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.05
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.01
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.01
    Ensembl ID: ENSG00000111275
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.98
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.97
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.94
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.89
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.87
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.82
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.82
    Ensembl ID: ENSG00000198363
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.79
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.71
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.71
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.66
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.64
    Ensembl ID: ENSG00000138772
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.63
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.56
    Ensembl ID: ENSG00000214274
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.55
    Ensembl ID: ENSG00000110092
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.55
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.54
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.53
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.53
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.48
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.46
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BIK (ENSG00000100290)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100290
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.43
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.43
    Ensembl ID: ENSG00000023445
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.41
    Ensembl ID: ENSG00000109321
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.38
    Ensembl ID: ENSG00000101444
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.3
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.29
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.28
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.28
    Ensembl ID: ENSG00000213465
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.25
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.22
    Ensembl ID: ENSG00000006756
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.21
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BCL3 (ENSG00000069399)
    Fold Change: 1.2
    Ensembl ID: ENSG00000069399
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.18
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.16
    Ensembl ID: ENSG00000161533
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.16
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.12
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.11
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.11
    Ensembl ID: ENSG00000126522
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.05
    Ensembl ID: ENSG00000170017
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.05
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.04
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204574
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.03
    Ensembl ID: ENSG00000162433
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.03
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142599
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Mucus Secretion**: Mucous neck cells are equipped with numerous apical secretory vesicles containing mucins, which are released onto the epithelial surface to form a protective mucus barrier. 2. **Basal Displacement of Nucleus**: The nucleus of the mucous neck cell is displaced to the basal side of the cell, allowing for optimal secretion of mucins. 3. **Multiple Apical Secretory Vesicles**: The cell has multiple apical secretory vesicles that contain mucins, which are released onto the epithelial surface. 4. **Synonyms**: The mucous neck cell is also known as a neck cell. 5. **Gene Symbol**: The gene symbol for the mucous neck cell is B2M. **Clinical Significance** 1. **Infection and Injury Protection**: The mucous neck cell plays a crucial role in protecting against infection and injury by forming a protective mucus barrier. 2. **Respiratory and Gastrointestinal Diseases**: Abnormalities in mucous neck cell function have been implicated in various respiratory and gastrointestinal diseases, including chronic bronchitis, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). 3. **Cancer Development**: The mucous neck cell has been implicated in the development of certain types of cancer, including gastric cancer and lung cancer. 4. **Immunological Significance**: The mucous neck cell plays a role in the immune system, particularly in the presentation of antigens to immune cells. 5. **Neurological Disorders**: The mucous neck cell has been implicated in the pathogenesis of certain neurological disorders, including Alzheimer's disease and Parkinson's disease. **Pathways and Ontology** The mucous neck cell is involved in various biological pathways, including: 1. **Adaptive Immune System**: The mucous neck cell plays a role in the adaptive immune system, particularly in the presentation of antigens to immune cells. 2. **Amyloid Fiber Formation**: The mucous neck cell is involved in the formation of amyloid fibers, which are associated with various diseases, including Alzheimer's disease and amyloidosis. 3. **Antigen Presentation**: The mucous neck cell is involved in the presentation of antigens to immune cells. 4. **Innate Immune System**: The mucous neck cell plays a role in the innate immune system, particularly in the recognition of pathogens. 5. **Cytokine Signaling**: The mucous neck cell is involved in cytokine signaling, particularly in the production of cytokines that regulate the immune response. Overall, the mucous neck cell is a critical component of the epithelial lining and plays a key role in protecting against infection and injury, as well as regulating the immune response.