Details for: CL0000653

Cell ID: CL0000653

Cell Name: podocyte

Marker Score Threshold: 370
(Derived using integrated single-cell and genomic data)

Description: A specialized kidney epithelial cell, contained within a glomerulus, that contains "feet" that interdigitate with the "feet" of other podocytes.

Synonyms: epithelial cell of visceral layer of glomerular capsule, glomerular podocyte, glomerular visceral epithelial cell, kidney podocyte, renal podocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.62
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.29
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.05
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.53
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.51
    Ensembl ID: ENSG00000130402
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.42
    Ensembl ID: ENSG00000151914
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.32
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.32
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.25
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.14
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.13
    Ensembl ID: ENSG00000182718
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.96
    Ensembl ID: ENSG00000156273
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.93
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.92
    Ensembl ID: ENSG00000145741
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.92
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.88
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.88
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.87
    Ensembl ID: ENSG00000104765
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.86
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.85
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.85
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.8
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.8
    Ensembl ID: ENSG00000124172
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.79
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.7
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.69
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.68
    Ensembl ID: ENSG00000087274
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.66
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.62
    Ensembl ID: ENSG00000122786
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.58
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.53
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.53
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.51
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.49
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.45
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.45
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.42
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.42
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.4
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.4
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.4
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.4
    Ensembl ID: ENSG00000141522
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.39
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.37
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.36
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.35
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.34
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.34
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.33
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.31
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.3
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.29
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.29
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.28
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.27
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.27
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.26
    Ensembl ID: ENSG00000006125
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.26
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.26
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.21
    Ensembl ID: ENSG00000099624
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.2
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.19
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.17
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.17
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.15
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.13
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.13
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.12
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.1
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.1
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.09
    Ensembl ID: ENSG00000166747
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.08
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.08
    Ensembl ID: ENSG00000069849
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100077
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000171552
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149823
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.03
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.03
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.03
    Ensembl ID: ENSG00000175054
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142188
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.01
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.01
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: N/A
    Ensembl ID: ENSG00000058668
Hovered Details

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Hovered Details

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**Key Characteristics** Podocytes are characterized by their distinctive morphology, which includes: * **Foot processes**: Podocytes have long, thin process that interdigitate with those of other podocytes, forming a specialized structure known as the slit diaphragm. * **Slit diaphragm**: The slit diaphragm is a narrow opening between the foot processes of two podocytes, allowing for the filtration of blood components. * **Basolateral membrane**: The basolateral membrane is the outer surface of the podocyte, where it interacts with the surrounding tissue. * **Anterior surface**: The anterior surface of the podocyte is exposed to the bloodstream and contains the slit diaphragm. Podocytes also express a range of surface proteins and adhesion molecules, including: * **Nephroslitin**: A transmembrane protein that is involved in the formation of the slit diaphragm. * **Nephrocytes**: A transmembrane protein that is involved in the regulation of podocyte function. * **CD34**: A surface protein that is involved in the regulation of podocyte function and the maintenance of the glomerular filtration barrier. **Clinical Significance** Podocytes are essential for maintaining the integrity of the glomerular filtration barrier, and their dysfunction is associated with various kidney diseases, including: * **Nephrotic syndrome**: A condition characterized by the loss of large amounts of protein in the urine, due to the disruption of the glomerular filtration barrier. * **Diabetic nephropathy**: A condition characterized by the damage to the kidneys caused by high blood sugar levels, which can lead to the loss of podocytes and the disruption of the glomerular filtration barrier. * **Glomerulonephritis**: A condition characterized by the inflammation of the glomeruli, which can lead to the loss of podocytes and the disruption of the glomerular filtration barrier. Understanding the function and dysfunction of podocytes is essential for the diagnosis and treatment of kidney diseases, and further research is needed to develop effective therapies for these conditions.