Details for: CL0000670

Cell ID: CL0000670

Cell Name: primordial germ cell

Marker Score Threshold: 1254
(Derived using integrated single-cell and genomic data)

Description: A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.

Synonyms: gonocyte, primitive germ cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.3
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.09
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.06
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.01
    Ensembl ID: ENSG00000075624
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.93
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.9
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.85
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.84
    Ensembl ID: ENSG00000169100
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.83
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.82
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.82
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.8
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.79
    Ensembl ID: ENSG00000149925
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.79
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.75
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.74
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.73
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130208
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.7
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.7
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.68
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.64
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.62
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.61
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.6
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.6
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.6
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.6
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.59
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.59
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.57
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.56
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.56
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.56
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.52
    Ensembl ID: ENSG00000162433
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104765
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.51
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.5
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.48
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.48
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.47
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.46
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.46
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.46
    Ensembl ID: ENSG00000239900
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.43
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.4
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BARD1 (ENSG00000138376)
    Fold Change: 1.4
    Ensembl ID: ENSG00000138376
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.4
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.39
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.39
    Ensembl ID: ENSG00000160710
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.39
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.38
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.37
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.34
    Ensembl ID: ENSG00000120805
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.34
    Ensembl ID: ENSG00000085662
  • Gene Symbol: BLMH (ENSG00000108578)
    Fold Change: 1.33
    Ensembl ID: ENSG00000108578
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.31
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.3
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.26
    Ensembl ID: ENSG00000136518
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.21
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.18
    Ensembl ID: ENSG00000035687
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.18
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.18
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.16
    Ensembl ID: ENSG00000120437
  • Gene Symbol: POLR3D (ENSG00000168495)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168495
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.14
    Ensembl ID: ENSG00000156110
  • Gene Symbol: NUDT2 (ENSG00000164978)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164978
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.12
    Ensembl ID: ENSG00000101966
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.1
    Ensembl ID: ENSG00000140299
  • Gene Symbol: BMI1 (ENSG00000168283)
    Fold Change: 1.09
    Ensembl ID: ENSG00000168283
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.08
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AGA (ENSG00000038002)
    Fold Change: 1.08
    Ensembl ID: ENSG00000038002
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.08
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.07
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.03
    Ensembl ID: ENSG00000102575
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.01
    Ensembl ID: ENSG00000141522
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1
    Ensembl ID: ENSG00000147872
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Diploid Germ Cell Precursor**: Primordial germ cells are diploid, meaning they have two sets of chromosomes, one from each parent. 2. **Transient Existence**: They exist transiently in the embryo before becoming irreversibly committed as germ cells. 3. **Involvement in Cell-Cell Communication**: Primordial germ cells interact with somatic cells of the gonad, which is essential for their development and function. 4. **Regulation of Actin Dynamics**: The gene symbol ACTG1 is associated with this cell, and it regulates actin dynamics, which is crucial for cell migration and movement. 5. **Signaling Pathways**: Primordial germ cells are involved in various signaling pathways, including those related to cell migration, cell motility, and development. **Clinical Significance** 1. **Reproductive System Development**: Primordial germ cells play a crucial role in the development of the reproductive system, including the formation of gametes (sperm and eggs). 2. **Cancer and Tumor Development**: Abnormalities in primordial germ cells can lead to cancer and tumor development, including testicular cancer and ovarian cancer. 3. **Infertility and Reproductive Disorders**: Primordial germ cells are essential for fertility, and abnormalities in these cells can lead to infertility and reproductive disorders. 4. **Genetic Disorders**: Primordial germ cells can carry genetic disorders, such as mutations in the gene ACTG1, which can lead to developmental abnormalities and diseases. 5. **Stem Cell Research**: Primordial germ cells are a type of stem cell that can be used for research and potential therapeutic applications, including regenerative medicine and cancer treatment. In conclusion, the primordial germ cell (CL0000670) is a crucial cell type involved in the development of the reproductive system and plays a significant role in various cellular processes. Its dysregulation can lead to various clinical disorders, including cancer, infertility, and reproductive disorders. Further research on this cell type can provide insights into the development of new therapeutic strategies for these disorders.