Details for: CL0000677

Cell ID: CL0000677

Cell Name: gut absorptive cell

Marker Score Threshold: 640
(Derived using integrated single-cell and genomic data)

Description: Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.73
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.61
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.55
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.49
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.47
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.4
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.36
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.35
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.32
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.27
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.26
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.19
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.14
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.1
    Ensembl ID: ENSG00000179218
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.08
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.01
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.97
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.93
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.92
    Ensembl ID: ENSG00000122545
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.92
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.92
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.91
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.9
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.85
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.84
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.8
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.76
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.72
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.72
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.71
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.71
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.71
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.69
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.66
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.66
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.65
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.64
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.62
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.61
    Ensembl ID: ENSG00000127022
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.61
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.59
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.55
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.54
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.54
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.51
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.49
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.48
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.47
    Ensembl ID: ENSG00000042753
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.45
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.4
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.4
    Ensembl ID: ENSG00000123505
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.39
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.37
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.37
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.37
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.37
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.36
    Ensembl ID: ENSG00000221869
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.35
    Ensembl ID: ENSG00000172216
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.35
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.34
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.32
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.32
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.32
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.31
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.31
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.29
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.26
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.2
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.19
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104765
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.18
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162772
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.14
    Ensembl ID: ENSG00000147872
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.12
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.08
    Ensembl ID: ENSG00000177879
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.07
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.07
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.06
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143153
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.06
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.06
    Ensembl ID: ENSG00000081181
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.05
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.05
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.04
    Ensembl ID: ENSG00000196776
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.02
    Ensembl ID: ENSG00000162909
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138760
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The gut absorptive cell has several key characteristics that enable its specialized function: 1. **Brush border**: The cell's brush border is composed of many parallel-packed microvilli, which increases the surface area for absorption. 2. **Microvilli**: The microvilli are small, finger-like projections that extend from the cell surface, increasing the surface area for absorption. 3. **Apical junction complex**: The apical junction complex is a specialized structure that forms between adjacent cells, allowing for tight junctions and adherens junctions to maintain cell polarity and integrity. 4. **Actin cytoskeleton**: The actin cytoskeleton plays a crucial role in maintaining cell shape and facilitating the movement of vesicles and organelles within the cell. 5. **Adherens junctions**: Adherens junctions are specialized structures that form between adjacent cells, allowing for cell-cell adhesion and maintaining tissue architecture. **Clinical Significance** The gut absorptive cell plays a critical role in maintaining the homeostasis of the body, particularly in terms of nutrient absorption. Dysfunction or abnormalities in these cells can lead to various clinical conditions, including: 1. **Malabsorption syndromes**: Conditions such as celiac disease, Crohn's disease, and ulcerative colitis can lead to malabsorption of nutrients due to damage to the gut absorptive cells. 2. **Inflammatory bowel disease**: Conditions such as Crohn's disease and ulcerative colitis can lead to inflammation and damage to the gut absorptive cells, resulting in malabsorption. 3. **Celiac disease**: An autoimmune disease that causes damage to the gut absorptive cells, leading to malabsorption of nutrients. 4. **Gastrointestinal disorders**: Conditions such as gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) can lead to dysfunction of the gut absorptive cells, resulting in malabsorption. In conclusion, the gut absorptive cell is a specialized epithelial cell that plays a critical role in maintaining the homeostasis of the body through nutrient absorption. Dysfunction or abnormalities in these cells can lead to various clinical conditions, highlighting the importance of understanding the biology of these cells.