Details for: CL0000681

Cell ID: CL0000681

Cell Name: radial glial cell

Marker Score Threshold: 369
(Derived using integrated single-cell and genomic data)

Description: A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration.

Synonyms: forebrain radial glial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.83
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 4.73
    Ensembl ID: ENSG00000127184
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.71
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 4.47
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 4.35
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.24
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.23
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 4.08
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 3.94
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.78
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.53
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 3.32
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 3.3
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.29
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.28
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.22
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 3.16
    Ensembl ID: ENSG00000126267
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.96
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.93
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.9
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.89
    Ensembl ID: ENSG00000152234
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 2.67
    Ensembl ID: ENSG00000131174
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.56
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.56
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.51
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.5
    Ensembl ID: ENSG00000005022
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 2.44
    Ensembl ID: ENSG00000155368
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.31
    Ensembl ID: ENSG00000166710
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 2.31
    Ensembl ID: ENSG00000129562
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.26
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.15
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.07
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 2.03
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.9
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.89
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.8
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CSNK2B (ENSG00000204435)
    Fold Change: 1.78
    Ensembl ID: ENSG00000204435
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.77
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.76
    Ensembl ID: ENSG00000177556
  • Gene Symbol: VCAN (ENSG00000038427)
    Fold Change: 1.76
    Ensembl ID: ENSG00000038427
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.71
    Ensembl ID: ENSG00000042753
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.71
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.69
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.69
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.67
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.6
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.58
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.51
    Ensembl ID: ENSG00000138175
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.49
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.49
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.48
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.47
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.47
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.45
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.44
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.43
    Ensembl ID: ENSG00000120885
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.42
    Ensembl ID: ENSG00000134480
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.42
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.41
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CKS2 (ENSG00000123975)
    Fold Change: 1.38
    Ensembl ID: ENSG00000123975
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.38
    Ensembl ID: ENSG00000051523
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.38
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.37
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.34
    Ensembl ID: ENSG00000099624
  • Gene Symbol: DARS1 (ENSG00000115866)
    Fold Change: 1.34
    Ensembl ID: ENSG00000115866
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.33
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CDK4 (ENSG00000135446)
    Fold Change: 1.33
    Ensembl ID: ENSG00000135446
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.3
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.29
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.27
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CKS1B (ENSG00000173207)
    Fold Change: 1.26
    Ensembl ID: ENSG00000173207
  • Gene Symbol: DDX1 (ENSG00000079785)
    Fold Change: 1.26
    Ensembl ID: ENSG00000079785
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.24
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.24
    Ensembl ID: ENSG00000168374
  • Gene Symbol: DDOST (ENSG00000244038)
    Fold Change: 1.23
    Ensembl ID: ENSG00000244038
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.22
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.21
    Ensembl ID: ENSG00000096401
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.2
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.2
    Ensembl ID: ENSG00000168036
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.17
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.17
    Ensembl ID: ENSG00000120437
  • Gene Symbol: DDIT3 (ENSG00000175197)
    Fold Change: 1.15
    Ensembl ID: ENSG00000175197
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.14
    Ensembl ID: ENSG00000204574
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.12
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.06
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.04
    Ensembl ID: ENSG00000239900
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.03
    Ensembl ID: ENSG00000113712
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.01
    Ensembl ID: ENSG00000198356
  • Gene Symbol: AMBN (ENSG00000178522)
    Fold Change: 1
    Ensembl ID: ENSG00000178522
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1
    Ensembl ID: ENSG00000141522
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1
    Ensembl ID: ENSG00000143799
Hovered Details

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Hovered Details

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**Key Characteristics** Radial glial cells have several distinct characteristics that distinguish them from other types of cells in the CNS. These include: 1. **Unique morphology**: RGCs have a long, thin cytoplasm and a prominent nucleus, which allows them to extend processes in multiple directions. 2. **Expression of specific genes and proteins**: RGCs express a range of genes and proteins involved in cell migration, adhesion, and signaling, including ACTG1, COX7C, and CFL1. 3. **Role in neuronal migration and differentiation**: RGCs provide a scaffold for neuronal migration and differentiation, allowing neurons to navigate and organize themselves in the developing CNS. 4. **Maintenance of the blood-brain barrier**: RGCs help to maintain the blood-brain barrier, which is essential for the proper functioning of the CNS. 5. **Involvement in immune responses**: RGCs are involved in the regulation of immune responses in the CNS, including the clearance of pathogens and the regulation of inflammation. **Clinical Significance** Radial glial cells have several clinical significance, including: 1. **Developmental disorders**: Abnormalities in RGC development and function have been implicated in various developmental disorders, including neurodevelopmental disorders and CNS tumors. 2. **Neurodegenerative diseases**: RGCs have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **CNS infections**: RGCs play a critical role in the clearance of pathogens from the CNS, and abnormalities in RGC function have been implicated in CNS infections, including meningitis and encephalitis. 4. **Blood-brain barrier dysfunction**: RGCs help to maintain the blood-brain barrier, and dysfunction of these cells has been implicated in various CNS disorders, including multiple sclerosis and stroke. 5. **Immunotherapy**: RGCs have been identified as a potential target for immunotherapy in the CNS, including the use of RGC-specific antibodies to modulate immune responses. Overall, radial glial cells play a critical role in the development and function of the CNS, and abnormalities in RGC function have been implicated in various CNS disorders. Further research is needed to fully understand the role of RGCs in the CNS and to develop effective therapeutic strategies for CNS disorders.