Details for: CL0000682

Cell ID: CL0000682

Cell Name: M cell of gut

Marker Score Threshold: 260
(Derived using integrated single-cell and genomic data)

Description: An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes.

Synonyms: M cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.31
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.1
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.72
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.63
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.45
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.4
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.36
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.3
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.24
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.23
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.13
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.06
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.06
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.04
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.03
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.03
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.96
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.95
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.92
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.88
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.83
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.77
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.76
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.75
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.73
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.73
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.65
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.63
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.61
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.6
    Ensembl ID: ENSG00000127022
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.57
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.56
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.56
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.55
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.53
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.52
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.52
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.5
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.5
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.48
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.46
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.46
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.42
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.42
    Ensembl ID: ENSG00000026508
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.4
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.39
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.38
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.37
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.35
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.33
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.32
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.3
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.3
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160014
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.26
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.26
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.25
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.25
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.24
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.23
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.23
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.22
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.21
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.2
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.19
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.19
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.18
    Ensembl ID: ENSG00000196975
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.18
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149925
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.17
    Ensembl ID: ENSG00000183255
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.16
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.14
    Ensembl ID: ENSG00000197894
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.13
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.12
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.08
    Ensembl ID: ENSG00000111275
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.07
    Ensembl ID: ENSG00000151914
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.04
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.03
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.03
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.02
    Ensembl ID: ENSG00000165527
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138760
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: N/A
    Ensembl ID: ENSG00000143878
Hovered Details

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Hovered Details

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**Key Characteristics** The M cell is characterized by several distinct features, including: 1. **Absorptive function**: M cells are specialized to absorb and internalize microorganisms and intact macromolecules from the gut lumen, which allows them to present antigens to the immune system. 2. **Tight junctions**: M cells form tight junctions with adjacent epithelial cells, which helps to maintain the integrity of the epithelial barrier and regulate the passage of antigens and other molecules. 3. **Surface molecule expression**: M cells express specific surface molecules, such as MHC class II and CD1d, which facilitate the uptake and presentation of antigens to antigen-presenting cells and lymphocytes. 4. **Apoptosis resistance**: M cells exhibit resistance to apoptosis, which allows them to maintain their absorptive function and continue to present antigens to the immune system. 5. **Expression of specific genes**: M cells express specific genes, such as ACTB and B2M, which are involved in the regulation of immune responses and the maintenance of intestinal homeostasis. **Clinical Significance** The M cell plays a crucial role in the immune system, and its dysfunction or dysregulation has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: M cells have been shown to play a key role in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. 2. **Infectious diseases**: M cells are essential for the initiation of immune responses against pathogens, such as bacteria and viruses, that infect the gut. 3. **Cancer**: M cells have been implicated in the development and progression of certain types of cancer, including colorectal cancer. 4. **Immunodeficiency diseases**: M cells are essential for the maintenance of immune function, and their dysfunction or dysregulation can lead to immunodeficiency diseases, such as severe combined immunodeficiency (SCID). Overall, the M cell is a critical component of the gut-associated lymphoid tissue (GALT) and plays a central role in the regulation of immune responses and the maintenance of intestinal homeostasis.