Details for: CL0000695

Cell ID: CL0000695

Cell Name: Cajal-Retzius cell

Marker Score Threshold: 518
(Derived using integrated single-cell and genomic data)

Description: A neuron of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. One feature of these cells in mammals is that they express the Reelin gene.

Synonyms: CR cells, Horizontal cells of Cajal

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MAGEA9 (ENSG00000123584)
    Fold Change: 1.67
    Ensembl ID: ENSG00000123584
  • Gene Symbol: RPL13 (ENSG00000167526)
    Fold Change: 1.54
    Ensembl ID: ENSG00000167526
  • Gene Symbol: RPLP1 (ENSG00000137818)
    Fold Change: 1.54
    Ensembl ID: ENSG00000137818
  • Gene Symbol: PRY (ENSG00000169789)
    Fold Change: 1.54
    Ensembl ID: ENSG00000169789
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: RPL11 (ENSG00000142676)
    Fold Change: 1.45
    Ensembl ID: ENSG00000142676
  • Gene Symbol: RPS8 (ENSG00000142937)
    Fold Change: 1.44
    Ensembl ID: ENSG00000142937
  • Gene Symbol: RPL34 (ENSG00000109475)
    Fold Change: 1.42
    Ensembl ID: ENSG00000109475
  • Gene Symbol: TPT1 (ENSG00000133112)
    Fold Change: 1.42
    Ensembl ID: ENSG00000133112
  • Gene Symbol: RPS6 (ENSG00000137154)
    Fold Change: 1.4
    Ensembl ID: ENSG00000137154
  • Gene Symbol: RPL30 (ENSG00000156482)
    Fold Change: 1.4
    Ensembl ID: ENSG00000156482
  • Gene Symbol: RPS27A (ENSG00000143947)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143947
  • Gene Symbol: RPL32 (ENSG00000144713)
    Fold Change: 1.4
    Ensembl ID: ENSG00000144713
  • Gene Symbol: RPS3 (ENSG00000149273)
    Fold Change: 1.4
    Ensembl ID: ENSG00000149273
  • Gene Symbol: RPS24 (ENSG00000138326)
    Fold Change: 1.39
    Ensembl ID: ENSG00000138326
  • Gene Symbol: RPL37A (ENSG00000197756)
    Fold Change: 1.39
    Ensembl ID: ENSG00000197756
  • Gene Symbol: RPL19 (ENSG00000108298)
    Fold Change: 1.39
    Ensembl ID: ENSG00000108298
  • Gene Symbol: RPL28 (ENSG00000108107)
    Fold Change: 1.39
    Ensembl ID: ENSG00000108107
  • Gene Symbol: RPL8 (ENSG00000161016)
    Fold Change: 1.38
    Ensembl ID: ENSG00000161016
  • Gene Symbol: RPS12 (ENSG00000112306)
    Fold Change: 1.38
    Ensembl ID: ENSG00000112306
  • Gene Symbol: RPL18 (ENSG00000063177)
    Fold Change: 1.38
    Ensembl ID: ENSG00000063177
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.38
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.38
    Ensembl ID: ENSG00000156508
  • Gene Symbol: RPLP2 (ENSG00000177600)
    Fold Change: 1.38
    Ensembl ID: ENSG00000177600
  • Gene Symbol: RPS14 (ENSG00000164587)
    Fold Change: 1.38
    Ensembl ID: ENSG00000164587
  • Gene Symbol: RPS27 (ENSG00000177954)
    Fold Change: 1.38
    Ensembl ID: ENSG00000177954
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 1.37
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 1.37
    Ensembl ID: ENSG00000087086
  • Gene Symbol: PTMA (ENSG00000187514)
    Fold Change: 1.36
    Ensembl ID: ENSG00000187514
  • Gene Symbol: RPS15 (ENSG00000115268)
    Fold Change: 1.36
    Ensembl ID: ENSG00000115268
  • Gene Symbol: RPL3 (ENSG00000100316)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100316
  • Gene Symbol: RPL35A (ENSG00000182899)
    Fold Change: 1.36
    Ensembl ID: ENSG00000182899
  • Gene Symbol: RPS2 (ENSG00000140988)
    Fold Change: 1.35
    Ensembl ID: ENSG00000140988
  • Gene Symbol: RPS28 (ENSG00000233927)
    Fold Change: 1.35
    Ensembl ID: ENSG00000233927
  • Gene Symbol: RPS23 (ENSG00000186468)
    Fold Change: 1.35
    Ensembl ID: ENSG00000186468
  • Gene Symbol: RPS4X (ENSG00000198034)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198034
  • Gene Symbol: RPL37 (ENSG00000145592)
    Fold Change: 1.34
    Ensembl ID: ENSG00000145592
  • Gene Symbol: RPL41 (ENSG00000229117)
    Fold Change: 1.34
    Ensembl ID: ENSG00000229117
  • Gene Symbol: RPL5 (ENSG00000122406)
    Fold Change: 1.33
    Ensembl ID: ENSG00000122406
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 1.33
    Ensembl ID: ENSG00000132475
  • Gene Symbol: RPL27A (ENSG00000166441)
    Fold Change: 1.33
    Ensembl ID: ENSG00000166441
  • Gene Symbol: RPS29 (ENSG00000213741)
    Fold Change: 1.33
    Ensembl ID: ENSG00000213741
  • Gene Symbol: RPL15 (ENSG00000174748)
    Fold Change: 1.33
    Ensembl ID: ENSG00000174748
  • Gene Symbol: RPS11 (ENSG00000142534)
    Fold Change: 1.32
    Ensembl ID: ENSG00000142534
  • Gene Symbol: RPL21 (ENSG00000122026)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122026
  • Gene Symbol: TMSB4X (ENSG00000205542)
    Fold Change: 1.3
    Ensembl ID: ENSG00000205542
  • Gene Symbol: RPL10 (ENSG00000147403)
    Fold Change: 1.3
    Ensembl ID: ENSG00000147403
  • Gene Symbol: RPS16 (ENSG00000105193)
    Fold Change: 1.3
    Ensembl ID: ENSG00000105193
  • Gene Symbol: RPL12 (ENSG00000197958)
    Fold Change: 1.29
    Ensembl ID: ENSG00000197958
  • Gene Symbol: RPS19 (ENSG00000105372)
    Fold Change: 1.29
    Ensembl ID: ENSG00000105372
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149806
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198804
  • Gene Symbol: RPLP0 (ENSG00000089157)
    Fold Change: 1.27
    Ensembl ID: ENSG00000089157
  • Gene Symbol: RPL31 (ENSG00000071082)
    Fold Change: 1.26
    Ensembl ID: ENSG00000071082
  • Gene Symbol: RPS3A (ENSG00000145425)
    Fold Change: 1.26
    Ensembl ID: ENSG00000145425
  • Gene Symbol: RPL23A (ENSG00000198242)
    Fold Change: 1.26
    Ensembl ID: ENSG00000198242
  • Gene Symbol: RPS15A (ENSG00000134419)
    Fold Change: 1.26
    Ensembl ID: ENSG00000134419
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 1.26
    Ensembl ID: ENSG00000111640
  • Gene Symbol: RPS21 (ENSG00000171858)
    Fold Change: 1.24
    Ensembl ID: ENSG00000171858
  • Gene Symbol: RPS13 (ENSG00000110700)
    Fold Change: 1.24
    Ensembl ID: ENSG00000110700
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198938
  • Gene Symbol: RPL6 (ENSG00000089009)
    Fold Change: 1.23
    Ensembl ID: ENSG00000089009
  • Gene Symbol: RPL9 (ENSG00000163682)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163682
  • Gene Symbol: RPS5 (ENSG00000083845)
    Fold Change: 1.23
    Ensembl ID: ENSG00000083845
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198712
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 1.23
    Ensembl ID: ENSG00000122566
  • Gene Symbol: UBC (ENSG00000150991)
    Fold Change: 1.23
    Ensembl ID: ENSG00000150991
  • Gene Symbol: RPL38 (ENSG00000172809)
    Fold Change: 1.22
    Ensembl ID: ENSG00000172809
  • Gene Symbol: RPL14 (ENSG00000188846)
    Fold Change: 1.22
    Ensembl ID: ENSG00000188846
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 1.21
    Ensembl ID: ENSG00000198755
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 1.21
    Ensembl ID: ENSG00000092841
  • Gene Symbol: RPS7 (ENSG00000171863)
    Fold Change: 1.2
    Ensembl ID: ENSG00000171863
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 1.2
    Ensembl ID: ENSG00000080824
  • Gene Symbol: UBA52 (ENSG00000221983)
    Fold Change: 1.2
    Ensembl ID: ENSG00000221983
  • Gene Symbol: RPL7 (ENSG00000147604)
    Fold Change: 1.19
    Ensembl ID: ENSG00000147604
  • Gene Symbol: RPL27 (ENSG00000131469)
    Fold Change: 1.19
    Ensembl ID: ENSG00000131469
  • Gene Symbol: RPL29 (ENSG00000162244)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162244
  • Gene Symbol: RPS9 (ENSG00000170889)
    Fold Change: 1.19
    Ensembl ID: ENSG00000170889
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 1.17
    Ensembl ID: ENSG00000198899
  • Gene Symbol: RPS20 (ENSG00000008988)
    Fold Change: 1.14
    Ensembl ID: ENSG00000008988
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198886
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198727
  • Gene Symbol: RPL39 (ENSG00000198918)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198918
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196531
  • Gene Symbol: RPL18A (ENSG00000105640)
    Fold Change: 1.11
    Ensembl ID: ENSG00000105640
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131143
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 1.08
    Ensembl ID: ENSG00000189403
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123349
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.06
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RPL4 (ENSG00000174444)
    Fold Change: 1.06
    Ensembl ID: ENSG00000174444
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 1.06
    Ensembl ID: ENSG00000168028
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198840
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.05
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.05
    Ensembl ID: ENSG00000167658
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.04
    Ensembl ID: ENSG00000127184
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198888
  • Gene Symbol: RPL22 (ENSG00000116251)
    Fold Change: 1.04
    Ensembl ID: ENSG00000116251
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104529
  • Gene Symbol: RPL24 (ENSG00000114391)
    Fold Change: 1.01
    Ensembl ID: ENSG00000114391
  • Gene Symbol: UBB (ENSG00000170315)
    Fold Change: 1.01
    Ensembl ID: ENSG00000170315
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The Cajal-Retzius cell is a type of neuron that is characterized by the following key features: * Radial ascending processes that contact the pial surface * Horizontal axon plexus located in the deep marginal zone * Expression of the Reelin gene * Role in axon guidance and neuronal migration * Implicated in synaptic formation and plasticity **Clinical Significance** The Cajal-Retzius cell has been implicated in various neurological disorders, including: * Neurolathyrism: a genetic disorder caused by a mutation in the Reelin gene * Microcephaly: a condition characterized by a small head size, which is thought to be caused by impaired neuronal migration * Schizophrenia: a psychiatric disorder that is thought to be related to abnormalities in synaptic plasticity * Autism spectrum disorder: a neurological disorder characterized by impaired social interaction and communication, which is thought to be related to abnormalities in neuronal migration and synaptic formation The Cajal-Retzius cell has also been implicated in various neurological disorders, including: * Neurolathyrism: a genetic disorder caused by a mutation in the Reelin gene * Microcephaly: a condition characterized by a small head size, which is thought to be caused by impaired neuronal migration * Schizophrenia: a psychiatric disorder that is thought to be related to abnormalities in synaptic plasticity * Autism spectrum disorder: a neurological disorder characterized by impaired social interaction and communication, which is thought to be related to abnormalities in neuronal migration and synaptic formation **Potential Roles in Disease** The Cajal-Retzius cell has been implicated in various cellular processes, including: * Axon guidance and neuronal migration * Synaptic formation and plasticity * Regulation of gene expression * Modulation of immune responses The Cajal-Retzius cell has also been implicated in various neurological disorders, including: * Neurolathyrism: a genetic disorder caused by a mutation in the Reelin gene * Microcephaly: a condition characterized by a small head size, which is thought to be caused by impaired neuronal migration * Schizophrenia: a psychiatric disorder that is thought to be related to abnormalities in synaptic plasticity * Autism spectrum disorder: a neurological disorder characterized by impaired social interaction and communication, which is thought to be related to abnormalities in neuronal migration and synaptic formation **Conclusion** The Cajal-Retzius cell is a unique type of neuron that plays a crucial role in the development of the nervous system. Its expression of the Reelin gene and involvement in axon guidance, neuronal migration, and synaptic formation make it an important cell type to study. The Cajal-Retzius cell has been implicated in various neurological disorders, including neurolathyrism, microcephaly, schizophrenia, and autism spectrum disorder. Further research is needed to fully understand the role of the Cajal-Retzius cell in disease and to develop new therapeutic strategies for the treatment of these disorders.