Details for: CL0000696

Cell ID: CL0000696

Cell Name: PP cell

Marker Score Threshold: 225
(Derived using integrated single-cell and genomic data)

Description: A cell that stores and secretes pancreatic polypeptide hormone.

Synonyms: type F enteroendocrine cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.13
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.87
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.73
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.64
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.62
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.54
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.47
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.46
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.44
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.38
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.37
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.3
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.21
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.15
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.12
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.08
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 2.05
    Ensembl ID: ENSG00000105290
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 2.03
    Ensembl ID: ENSG00000137731
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.97
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.97
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.92
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.92
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.9
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.89
    Ensembl ID: ENSG00000133639
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.87
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143153
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.83
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.79
    Ensembl ID: ENSG00000135046
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.77
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.76
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.72
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.71
    Ensembl ID: ENSG00000165092
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.69
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.68
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.67
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.65
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.65
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.64
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.64
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.62
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.62
    Ensembl ID: ENSG00000131100
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.6
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.6
    Ensembl ID: ENSG00000138279
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.56
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.56
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165629
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.5
    Ensembl ID: ENSG00000121410
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.48
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.48
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.47
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.46
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.46
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.42
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.41
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.41
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.4
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.4
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.4
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.36
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.34
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.34
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.33
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.32
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.3
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.28
    Ensembl ID: ENSG00000100852
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.25
    Ensembl ID: ENSG00000006125
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100300
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.23
    Ensembl ID: ENSG00000204580
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.22
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.21
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.2
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.19
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.16
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.15
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 1.15
    Ensembl ID: ENSG00000091583
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.12
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.1
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.09
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.09
    Ensembl ID: ENSG00000002330
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.07
    Ensembl ID: ENSG00000101966
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.07
    Ensembl ID: ENSG00000126247
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.07
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.06
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.05
    Ensembl ID: ENSG00000170017
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.02
    Ensembl ID: ENSG00000140299
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.02
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: N/A
    Ensembl ID: ENSG00000095139
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: N/A
    Ensembl ID: ENSG00000142599
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Enteroendocrine cell**: PP cells are a type of enteroendocrine cell, which are specialized cells that produce and secrete hormones in response to various stimuli. 2. **Pancreatic polypeptide (PP) secretion**: PP cells store and secrete PP, a hormone that regulates pancreatic function and blood sugar levels. 3. **Adaptive immune system**: PP cells are involved in the adaptive immune system, which is responsible for specific responses to pathogens and other foreign substances. 4. **Antigen presentation**: PP cells are capable of presenting antigens to T cells, which is an essential process for activating immune responses. 5. **Cytokine signaling**: PP cells can produce and secrete cytokines, which are signaling molecules that regulate immune responses. **Clinical Significance** 1. **Pancreatic function**: PP cells play a crucial role in regulating pancreatic function, including the secretion of digestive enzymes and the regulation of blood sugar levels. 2. **Immune system regulation**: PP cells are involved in regulating immune responses, including the activation of immune cells and the production of cytokines. 3. **Bacterial infections**: PP cells are involved in the response to bacterial infections, including Mycobacterium tuberculosis. 4. **Autoimmune diseases**: PP cells may be involved in autoimmune diseases, such as type 1 diabetes, where the immune system attacks the pancreas and disrupts glucose regulation. 5. **Cancer**: PP cells may be involved in cancer development, particularly in pancreatic cancer, where the PP hormone can promote tumor growth and metastasis. In conclusion, the PP cell is a specialized enteroendocrine cell that plays a crucial role in regulating pancreatic function and immune responses. Its dysregulation has been implicated in various diseases, including autoimmune diseases and cancer. Further research is needed to fully understand the mechanisms by which PP cells regulate immune responses and to develop effective therapeutic strategies for treating diseases associated with PP cell dysfunction.