Details for: CL0000704

Cell ID: CL0000704

Cell Name: endothelial tip cell

Marker Score Threshold: 233
(Derived using integrated single-cell and genomic data)

Description: A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.8
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.32
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.18
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.83
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.78
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.74
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.61
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.59
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.47
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.39
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.32
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.22
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.07
    Ensembl ID: ENSG00000154518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.04
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.95
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.94
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.86
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.79
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.76
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.74
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.72
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.69
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.69
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.68
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.66
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.65
    Ensembl ID: ENSG00000153113
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.61
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.6
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.59
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.58
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.56
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.54
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.53
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.48
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CDH5 (ENSG00000179776)
    Fold Change: 1.46
    Ensembl ID: ENSG00000179776
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.45
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.45
    Ensembl ID: ENSG00000142192
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.44
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.42
    Ensembl ID: ENSG00000149257
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.4
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.4
    Ensembl ID: ENSG00000105974
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.39
    Ensembl ID: ENSG00000122359
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.38
    Ensembl ID: ENSG00000175899
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 1.37
    Ensembl ID: ENSG00000174059
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.33
    Ensembl ID: ENSG00000134480
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.31
    Ensembl ID: ENSG00000110651
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APLNR (ENSG00000134817)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134817
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.28
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.28
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.27
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.25
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.24
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.21
    Ensembl ID: ENSG00000177697
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.21
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.19
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.19
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.19
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.16
    Ensembl ID: ENSG00000121691
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.15
    Ensembl ID: ENSG00000090013
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.15
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.15
    Ensembl ID: ENSG00000085063
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.14
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ENTPD1 (ENSG00000138185)
    Fold Change: 1.14
    Ensembl ID: ENSG00000138185
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.14
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.12
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.11
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.1
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141522
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.07
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.06
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.05
    Ensembl ID: ENSG00000107262
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.05
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.04
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.04
    Ensembl ID: ENSG00000105971
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.02
    Ensembl ID: ENSG00000023445
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.02
    Ensembl ID: ENSG00000204217
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.02
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164615
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Specialized Endothelial Cell**: The cell is an endothelial tip cell, which is a specialized type of endothelial cell that plays a crucial role in the development and guidance of blood vessels. 2. **Extracellular Signal Sensing**: The cell is able to sense extracellular signals, which allows it to regulate the directed growth of blood vessels. 3. **Actin Cytoskeleton Organization**: The cell's genes, including ACTB, are involved in the organization of the actin cytoskeleton, which is essential for cell movement and shape changes. 4. **Antigen Presentation**: The cell's genes, including B2M, are involved in the presentation of antigens to the immune system, which is essential for immune system regulation. 5. **Immune System Regulation**: The cell's pathways and ontologies are involved in the regulation of the immune system, including adaptive immune system, innate immune system, and cytokine signaling. **Clinical Significance** 1. **Blood Vessel Development**: The cell's ability to sense extracellular signals and regulate the directed growth of blood vessels is essential for normal blood vessel development. 2. **Vascular Disease**: Abnormalities in endothelial tip cell function have been implicated in various vascular diseases, including atherosclerosis and hypertension. 3. **Immune System Regulation**: The cell's ability to regulate the immune system is essential for preventing autoimmune diseases and maintaining immune homeostasis. 4. **Cancer Metastasis**: The cell's ability to regulate cell growth and migration is essential for cancer metastasis, and abnormalities in endothelial tip cell function have been implicated in various types of cancer. 5. **Regenerative Medicine**: The cell's ability to regulate blood vessel development and immune system function makes it a potential target for regenerative medicine therapies, including tissue engineering and immunotherapy. In conclusion, the endothelial tip cell is a specialized cell that plays a crucial role in the development and guidance of blood vessels, and its dysfunction has been implicated in various diseases. Further research is needed to fully understand the cell's mechanisms and to develop effective therapies for vascular and immune system disorders.