Details for: CL0000708

Cell ID: CL0000708

Cell Name: leptomeningeal cell

Marker Score Threshold: 494
(Derived using integrated single-cell and genomic data)

Description: Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus.

Synonyms: leptomemingeal cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.95
    Ensembl ID: ENSG00000145362
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.87
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.8
    Ensembl ID: ENSG00000170017
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.6
    Ensembl ID: ENSG00000198668
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.54
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.52
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.46
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143933
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.39
    Ensembl ID: ENSG00000189058
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 2.3
    Ensembl ID: ENSG00000153162
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.18
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.13
    Ensembl ID: ENSG00000156110
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.12
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.11
    Ensembl ID: ENSG00000085224
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.09
    Ensembl ID: ENSG00000168675
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.06
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.02
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.02
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.99
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.98
    Ensembl ID: ENSG00000075624
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.95
    Ensembl ID: ENSG00000066382
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.9
    Ensembl ID: ENSG00000157764
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.87
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.81
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.79
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.75
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.74
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.69
    Ensembl ID: ENSG00000174437
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.68
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.66
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.66
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.65
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.64
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.63
    Ensembl ID: ENSG00000097007
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.62
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.62
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.61
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.61
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: 1.48
    Ensembl ID: ENSG00000112175
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.47
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.44
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 1.44
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.43
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.41
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.39
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.37
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.36
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.33
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.33
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.31
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.29
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.29
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BMP7 (ENSG00000101144)
    Fold Change: 1.29
    Ensembl ID: ENSG00000101144
  • Gene Symbol: BMP4 (ENSG00000125378)
    Fold Change: 1.27
    Ensembl ID: ENSG00000125378
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.25
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.24
    Ensembl ID: ENSG00000131100
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.23
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.22
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.22
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 1.21
    Ensembl ID: ENSG00000108381
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.2
    Ensembl ID: ENSG00000101966
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.2
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.18
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.18
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.17
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.16
    Ensembl ID: ENSG00000114573
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.14
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.12
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.12
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.12
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115361
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.1
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165029
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 1.06
    Ensembl ID: ENSG00000133805
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.06
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.06
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.05
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.04
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.01
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.01
    Ensembl ID: ENSG00000157087
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.01
    Ensembl ID: ENSG00000171552
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: N/A
    Ensembl ID: ENSG00000148090
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Leptomeningeal cell, a type of stromal cell. 2. **Location**: Internal covering of the vertebrate brain and choroid plexus. 3. **Function**: Produces extracellular matrix (ECM) for the brain and choroid plexus. 4. **Gene Symbol**: ANK2. 5. **Protein Binding**: Interacts with L1CAM, calmodulin, and calcium channels. 6. **Signal Transduction**: Involved in cell adhesion, signaling, and metabolism. 7. **Cytoskeletal Organization**: Structurally related to the cytoskeleton. 8. **Metabolic Processes**: Involvement in glycogen metabolism, protein metabolism, and calcium ion homeostasis. **Clinical Significance** 1. **Neurological Disorders**: Leptomeningeal cells may be involved in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Cancer**: Alterations in the expression of ANK2 may be associated with cancer development and progression. 3. **Infectious Diseases**: Leptomeningeal cells may play a role in the pathogenesis of infectious diseases, such as meningitis and encephalitis. 4. **Neurodevelopmental Disorders**: Abnormalities in leptomeningeal cells may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 5. **Cardiac Conduction**: The cell's interaction with calcium channels and calmodulin may be involved in cardiac conduction and arrhythmias. **Pathways/Ontology** 1. **Atrial Cardiac Muscle Cell Action Potential**: Regulated by the cell's interaction with calcium channels and calmodulin. 2. **Axon Guidance**: Involved in the development and maintenance of axons. 3. **Cell Adhesion**: Regulated by the cell's interaction with L1CAM and other adhesion molecules. 4. **Dendrite Morphogenesis**: Involved in the development and maintenance of dendrites. 5. **Histone Deacetylase Complex**: Regulated by the cell's interaction with histone deacetylases. **Gene Symbol: RERE** 1. **Branching Morphogenesis of a Nerve**: Regulated by the cell's interaction with other genes and signaling pathways. 2. **Cerebellar Purkinje Cell Layer Maturation**: Involved in the development and maturation of cerebellar Purkinje cells. 3. **Chromatin Remodeling**: Regulated by the cell's interaction with chromatin remodeling complexes. 4. **Dendrite Morphogenesis**: Involved in the development and maintenance of dendrites. 5. **Gene Expression (Transcription)**: Regulated by the cell's interaction with transcription factors and other signaling molecules. **Gene Symbol: ALCAM** 1. **Adaptive Immune Response**: Regulated by the cell's interaction with other immune cells and signaling molecules. 2. **Axon Guidance**: Involved in the development and maintenance of axons. 3. **Cell Adhesion**: Regulated by the cell's interaction with L1CAM and other adhesion molecules. 4. **Immunological Synapse**: Involved in the development and maintenance of immunological synapses. 5. **Neuronal Cell Body**: Regulated by the cell's interaction with other neuronal cells and signaling molecules. **Gene Symbol: CALM1** 1. **Activation of AMPK Downstream of NMDARs**: Regulated by the cell's interaction with AMPK and NMDARs. 2. **Activation of Ca-Permeable Kainate Receptor**: Involved in the development and maintenance of excitatory neurotransmission. 3. **Activation of Kainate Receptors upon Glutamate Binding**: Regulated by the cell's interaction with glutamate receptors and signaling molecules. 4. **Activation of NMDA Receptors and Postsynaptic Events**: Involved in the development and maintenance of excitatory neurotransmission. 5. **Calcium-Dependent Protein Binding**: Regulated by the cell's interaction with calcium channels and calmodulin.