Details for: CL0000731

Cell ID: CL0000731

Cell Name: urothelial cell

Marker Score Threshold: 462
(Derived using integrated single-cell and genomic data)

Description: A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria.

Synonyms: urinary tract transitional epithelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.34
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.34
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.33
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.32
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.24
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.22
    Ensembl ID: ENSG00000111640
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.08
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.03
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.01
    Ensembl ID: ENSG00000169100
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.98
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.98
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.97
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.94
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.84
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.76
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.73
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.73
    Ensembl ID: ENSG00000156976
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.72
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.71
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.71
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.63
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.62
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.62
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.6
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143933
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.55
    Ensembl ID: ENSG00000089280
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.55
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.52
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.52
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.51
    Ensembl ID: ENSG00000077549
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.5
    Ensembl ID: ENSG00000110321
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.5
    Ensembl ID: ENSG00000120129
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.48
    Ensembl ID: ENSG00000179218
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.47
    Ensembl ID: ENSG00000067082
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.47
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.46
    Ensembl ID: ENSG00000111775
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.43
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.41
    Ensembl ID: ENSG00000169020
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 1.41
    Ensembl ID: ENSG00000170345
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152518
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.4
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.35
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.35
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.34
    Ensembl ID: ENSG00000185650
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100664
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.32
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.31
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.31
    Ensembl ID: ENSG00000051523
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.31
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.31
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.28
    Ensembl ID: ENSG00000172270
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.26
    Ensembl ID: ENSG00000131174
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.25
    Ensembl ID: ENSG00000215301
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.24
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.23
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.22
    Ensembl ID: ENSG00000085224
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.21
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.21
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.21
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.2
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.2
    Ensembl ID: ENSG00000160213
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.18
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.18
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.18
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100632
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196419
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143420
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.14
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.13
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.13
    Ensembl ID: ENSG00000013441
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.12
    Ensembl ID: ENSG00000173674
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.11
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.1
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.08
    Ensembl ID: ENSG00000171634
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104964
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.08
    Ensembl ID: ENSG00000132507
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.07
    Ensembl ID: ENSG00000182944
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.05
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.05
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.04
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.03
    Ensembl ID: ENSG00000101439
  • Gene Symbol: FKBP1A (ENSG00000088832)
    Fold Change: 1.03
    Ensembl ID: ENSG00000088832
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.02
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.01
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.01
    Ensembl ID: ENSG00000168036
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1
    Ensembl ID: ENSG00000117984
Hovered Details

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Hovered Details

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**Key Characteristics** The urothelial cell has several distinct characteristics that distinguish it from other types of epithelial cells. These include: 1. **Large nucleus**: The nucleus of the urothelial cell is large and prominent, with a prominent nucleolus and a characteristic nuclear morphology. 2. **Microvilli**: The cell surface of the urothelial cell is covered with microvilli, which project into the lumen of the urinary tract and help to regulate the passage of urine. 3. **Golgi apparatus**: The Golgi apparatus is a large, complex organelle that is found in the cytoplasm of the urothelial cell. It plays a crucial role in the synthesis and modification of proteins and lipids. 4. **Actin cytoskeleton**: The urothelial cell has a dynamic actin cytoskeleton that is involved in cell motility, shape changes, and the regulation of cell signaling pathways. 5. **Apical junction complex**: The urothelial cell has a complex of apical junctions that are involved in the regulation of cell-cell adhesion and the maintenance of the epithelial barrier. **Clinical Significance** The urothelial cell plays a critical role in maintaining the integrity of the urinary tract and regulating the passage of urine. Abnormalities in the function or structure of the urothelial cell can lead to a range of clinical problems, including: 1. **Urinary tract infections**: The urothelial cell plays a crucial role in the defense against bacterial infections of the urinary tract. Abnormalities in the function or structure of the urothelial cell can lead to an increased risk of urinary tract infections. 2. **Cancer**: The urothelial cell is a common site for the development of cancer, including transitional cell carcinoma and squamous cell carcinoma. 3. **Bladder dysfunction**: The urothelial cell plays a critical role in the regulation of bladder function. Abnormalities in the function or structure of the urothelial cell can lead to bladder dysfunction, including overactive bladder and urinary incontinence. Overall, the urothelial cell is an important component of the urinary tract and plays a critical role in maintaining the integrity of the epithelial barrier and regulating the passage of urine. Abnormalities in the function or structure of the urothelial cell can have significant clinical implications, including an increased risk of urinary tract infections, cancer, and bladder dysfunction.