Details for: CL0000740

Cell ID: CL0000740

Cell Name: retinal ganglion cell

Marker Score Threshold: 1247
(Derived using integrated single-cell and genomic data)

Description: The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.

Synonyms: gangliocyte, ganglion cell of retina, RGC, RGCs

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CDK3 (ENSG00000250506)
    Fold Change: 5.13
    Ensembl ID: ENSG00000250506
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 4.68
    Ensembl ID: ENSG00000145362
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 3.97
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.49
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 2.79
    Ensembl ID: ENSG00000169252
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.63
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.53
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.52
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 2.52
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.5
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.46
    Ensembl ID: ENSG00000153956
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.44
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.36
    Ensembl ID: ENSG00000141837
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.3
    Ensembl ID: ENSG00000148408
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.17
    Ensembl ID: ENSG00000204217
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.16
    Ensembl ID: ENSG00000122545
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.12
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CEACAM8 (ENSG00000124469)
    Fold Change: 2.07
    Ensembl ID: ENSG00000124469
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 2
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.94
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.9
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.74
    Ensembl ID: ENSG00000085224
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.7
    Ensembl ID: ENSG00000121410
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.69
    Ensembl ID: ENSG00000079102
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.69
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.65
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.64
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.64
    Ensembl ID: ENSG00000170558
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.64
    Ensembl ID: ENSG00000119138
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 1.62
    Ensembl ID: ENSG00000154162
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.61
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.6
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.6
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.59
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.58
    Ensembl ID: ENSG00000152092
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.54
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 1.54
    Ensembl ID: ENSG00000140937
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.52
    Ensembl ID: ENSG00000162772
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.48
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.46
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.45
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CD40 (ENSG00000101017)
    Fold Change: 1.44
    Ensembl ID: ENSG00000101017
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 1.44
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 1.44
    Ensembl ID: ENSG00000133019
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.44
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.39
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CHRM5 (ENSG00000184984)
    Fold Change: 1.38
    Ensembl ID: ENSG00000184984
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.37
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 1.37
    Ensembl ID: ENSG00000145526
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.37
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.35
    Ensembl ID: ENSG00000095139
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.34
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.32
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.32
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 1.32
    Ensembl ID: ENSG00000128656
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 1.31
    Ensembl ID: ENSG00000140945
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.31
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.31
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.3
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.29
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.28
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143761
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.26
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.26
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.25
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.25
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.23
    Ensembl ID: ENSG00000135404
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.22
    Ensembl ID: ENSG00000152495
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.22
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.2
    Ensembl ID: ENSG00000156110
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.17
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.16
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.15
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.14
    Ensembl ID: ENSG00000131473
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.14
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.13
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CARS1 (ENSG00000110619)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110619
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138760
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.1
    Ensembl ID: ENSG00000090861
  • Gene Symbol: CLCN1 (ENSG00000188037)
    Fold Change: 1.09
    Ensembl ID: ENSG00000188037
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.08
    Ensembl ID: ENSG00000166165
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.07
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.06
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BIK (ENSG00000100290)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100290
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.02
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.01
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.01
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ATP7A (ENSG00000165240)
    Fold Change: 1.01
    Ensembl ID: ENSG00000165240
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.01
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1
    Ensembl ID: ENSG00000111642
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1
    Ensembl ID: ENSG00000172270
Hovered Details

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Hovered Details

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**Key Characteristics** * **Location**: Retinal ganglion cells are located in the retina, specifically in the innermost layer of the retina. * **Function**: RGCs receive neural inputs from bipolar, horizontal, and amacrine cells and transmit visual information to the brain through the optic nerve. * **Structure**: RGCs have a characteristic morphology, with a cell body, axon, and dendrites. * **Gene expression**: RGCs are encoded by several genes, including CDK3, ANK2, and GRK3, which are involved in various cellular processes such as cell cycle regulation, signal transduction, and protein phosphorylation. * **Synonyms**: Gangliocyte, Ganglion cell of retina, RGC, RGCs **Clinical Significance** * **Visual impairment**: RGCs are responsible for transmitting visual information from the eye to the brain, and damage to these cells can lead to visual impairment or blindness. * **Glaucoma**: RGCs are susceptible to damage from increased intraocular pressure, which can lead to glaucoma, a condition characterized by progressive visual field loss. * **Diabetes**: Diabetes can damage RGCs, leading to diabetic retinopathy, a condition characterized by damage to the blood vessels in the retina. * **Circadian rhythm regulation**: RGCs play a role in regulating the circadian rhythm, and disruptions to this process can lead to sleep disorders and other physiological problems. * **Cardiac function**: RGCs are also expressed in cardiac muscle cells, where they play a role in regulating heart rate and contractility. In conclusion, retinal ganglion cells are a critical component of the visual system, and their dysfunction can lead to a range of clinical problems, including visual impairment, glaucoma, and circadian rhythm regulation disorders. Further research is needed to understand the molecular mechanisms underlying RGC function and dysfunction, and to develop effective treatments for these conditions.