Details for: CL0000745

Cell ID: CL0000745

Cell Name: retina horizontal cell

Marker Score Threshold: 959
(Derived using integrated single-cell and genomic data)

Description: A neuron that laterally connects other neurons in the inner nuclear layer of the retina.

Synonyms: horizontal cell, HC, HCs

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CLDN4 (ENSG00000189143)
    Fold Change: 6.9
    Ensembl ID: ENSG00000189143
  • Gene Symbol: CLC (ENSG00000105205)
    Fold Change: 5.89
    Ensembl ID: ENSG00000105205
  • Gene Symbol: CRHR1 (ENSG00000120088)
    Fold Change: 5.7
    Ensembl ID: ENSG00000120088
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 5.14
    Ensembl ID: ENSG00000170214
  • Gene Symbol: COL19A1 (ENSG00000082293)
    Fold Change: 5.14
    Ensembl ID: ENSG00000082293
  • Gene Symbol: COL10A1 (ENSG00000123500)
    Fold Change: 5.12
    Ensembl ID: ENSG00000123500
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 4.98
    Ensembl ID: ENSG00000091138
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 4.94
    Ensembl ID: ENSG00000145692
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 4.84
    Ensembl ID: ENSG00000161905
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 4.8
    Ensembl ID: ENSG00000102010
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 4.6
    Ensembl ID: ENSG00000039537
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 4.59
    Ensembl ID: ENSG00000160683
  • Gene Symbol: CYP3A7 (ENSG00000160870)
    Fold Change: 4.57
    Ensembl ID: ENSG00000160870
  • Gene Symbol: CDK3 (ENSG00000250506)
    Fold Change: 4.55
    Ensembl ID: ENSG00000250506
  • Gene Symbol: CENPA (ENSG00000115163)
    Fold Change: 4.55
    Ensembl ID: ENSG00000115163
  • Gene Symbol: CFTR (ENSG00000001626)
    Fold Change: 4.55
    Ensembl ID: ENSG00000001626
  • Gene Symbol: ASIP (ENSG00000101440)
    Fold Change: 4.52
    Ensembl ID: ENSG00000101440
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 4.51
    Ensembl ID: ENSG00000108839
  • Gene Symbol: CYP3A4 (ENSG00000160868)
    Fold Change: 4.46
    Ensembl ID: ENSG00000160868
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 4.44
    Ensembl ID: ENSG00000165269
  • Gene Symbol: DIO1 (ENSG00000211452)
    Fold Change: 4.23
    Ensembl ID: ENSG00000211452
  • Gene Symbol: CBS (ENSG00000160200)
    Fold Change: 4.11
    Ensembl ID: ENSG00000160200
  • Gene Symbol: CA1 (ENSG00000133742)
    Fold Change: 3.89
    Ensembl ID: ENSG00000133742
  • Gene Symbol: CR1L (ENSG00000197721)
    Fold Change: 3.82
    Ensembl ID: ENSG00000197721
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 3.82
    Ensembl ID: ENSG00000118520
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.56
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 3.49
    Ensembl ID: ENSG00000156150
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 3.42
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ART4 (ENSG00000111339)
    Fold Change: 3.35
    Ensembl ID: ENSG00000111339
  • Gene Symbol: DAO (ENSG00000110887)
    Fold Change: 3.27
    Ensembl ID: ENSG00000110887
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 3.22
    Ensembl ID: ENSG00000075673
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 3.12
    Ensembl ID: ENSG00000136872
  • Gene Symbol: EDNRA (ENSG00000151617)
    Fold Change: 2.85
    Ensembl ID: ENSG00000151617
  • Gene Symbol: CSF1R (ENSG00000182578)
    Fold Change: 2.72
    Ensembl ID: ENSG00000182578
  • Gene Symbol: C5AR1 (ENSG00000197405)
    Fold Change: 2.67
    Ensembl ID: ENSG00000197405
  • Gene Symbol: CNGA4 (ENSG00000132259)
    Fold Change: 2.52
    Ensembl ID: ENSG00000132259
  • Gene Symbol: DNAH8 (ENSG00000124721)
    Fold Change: 2.4
    Ensembl ID: ENSG00000124721
  • Gene Symbol: DRD3 (ENSG00000151577)
    Fold Change: 2.35
    Ensembl ID: ENSG00000151577
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 2.32
    Ensembl ID: ENSG00000113600
  • Gene Symbol: CD80 (ENSG00000121594)
    Fold Change: 2.32
    Ensembl ID: ENSG00000121594
  • Gene Symbol: BRDT (ENSG00000137948)
    Fold Change: 2.17
    Ensembl ID: ENSG00000137948
  • Gene Symbol: BUB1 (ENSG00000169679)
    Fold Change: 2.13
    Ensembl ID: ENSG00000169679
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: 2.03
    Ensembl ID: ENSG00000014257
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.87
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.78
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CYP8B1 (ENSG00000180432)
    Fold Change: 1.78
    Ensembl ID: ENSG00000180432
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.75
    Ensembl ID: ENSG00000156508
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.65
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.64
    Ensembl ID: ENSG00000184254
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.64
    Ensembl ID: ENSG00000172757
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.61
    Ensembl ID: ENSG00000166710
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.61
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.61
    Ensembl ID: ENSG00000167658
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.6
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.6
    Ensembl ID: ENSG00000115361
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.56
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTC (ENSG00000174808)
    Fold Change: 1.55
    Ensembl ID: ENSG00000174808
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.55
    Ensembl ID: ENSG00000139193
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.55
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.54
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.51
    Ensembl ID: ENSG00000112695
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.5
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.45
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.45
    Ensembl ID: ENSG00000135940
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.44
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CTSS (ENSG00000163131)
    Fold Change: 1.43
    Ensembl ID: ENSG00000163131
  • Gene Symbol: CRYAA (ENSG00000160202)
    Fold Change: 1.4
    Ensembl ID: ENSG00000160202
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.38
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.35
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.32
    Ensembl ID: ENSG00000154723
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.32
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDH9 (ENSG00000113100)
    Fold Change: 1.29
    Ensembl ID: ENSG00000113100
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.28
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.27
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.27
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.23
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.22
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.22
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.21
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.2
    Ensembl ID: ENSG00000117410
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.17
    Ensembl ID: ENSG00000114942
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104529
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.14
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.13
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CHI3L2 (ENSG00000064886)
    Fold Change: 1.13
    Ensembl ID: ENSG00000064886
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.12
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.08
    Ensembl ID: ENSG00000166165
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.07
    Ensembl ID: ENSG00000105409
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.06
    Ensembl ID: ENSG00000026508
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.06
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.06
    Ensembl ID: ENSG00000185650
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.04
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143761
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.03
    Ensembl ID: ENSG00000067560
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1
    Ensembl ID: ENSG00000134825
Hovered Details

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Hovered Details

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**Key Characteristics** * Retina horizontal cells are neurons that laterally connect other neurons in the inner nuclear layer of the retina. * They play a crucial role in visual processing and communication. * The cell type CL0000745 is identified by its gene symbol CLDN4 and Ensembl ID ENSG00000189143. * It is associated with other genes such as CLC, CRHR1, ADRA1B, COL19A1, COL10A1, SLC26A3, BHMT, and ALOX15, which are involved in various cellular processes. * Retina horizontal cells are involved in cell-cell adhesion, signaling, and metabolism. * They are sensitive to various stimuli, including light, motion, and chemical signals. * Abnormalities in retina horizontal cells have been linked to various diseases and disorders, including retinitis pigmentosa, age-related macular degeneration, and glaucoma. **Clinical Significance** * Understanding the function and regulation of retina horizontal cells is crucial for the diagnosis and treatment of various diseases and disorders. * Abnormalities in retina horizontal cells have been linked to various diseases and disorders, including retinitis pigmentosa, age-related macular degeneration, and glaucoma. * Retina horizontal cells play a crucial role in visual processing and communication, and their dysfunction can lead to visual impairments and blindness. * Research on retina horizontal cells has the potential to lead to the development of new treatments for various eye diseases and disorders. * The study of retina horizontal cells can also provide insights into the mechanisms of visual processing and the development of new technologies for visual prosthetics and implants. **Diseases and Disorders Associated with Retina Horizontal Cells** * Retinitis pigmentosa: a genetic disorder that affects the retina and leads to progressive vision loss. * Age-related macular degeneration: a condition that affects the macula, the part of the retina responsible for central vision, and can lead to blindness. * Glaucoma: a group of eye conditions that damage the optic nerve, leading to vision loss and blindness. * Leber congenital amaurosis: a rare genetic disorder that affects the retina and leads to severe vision loss or blindness from birth. * Usher syndrome: a genetic disorder that affects the retina and leads to progressive vision loss and hearing loss. **Future Research Directions** * Understanding the function and regulation of retina horizontal cells is crucial for the diagnosis and treatment of various diseases and disorders. * Research on retina horizontal cells has the potential to lead to the development of new treatments for various eye diseases and disorders. * The study of retina horizontal cells can also provide insights into the mechanisms of visual processing and the development of new technologies for visual prosthetics and implants. * Future research should focus on the development of new therapeutic strategies for retina horizontal cells, including gene therapy and optogenetics. * Additionally, research on retina horizontal cells can also provide insights into the mechanisms of other diseases and disorders, including neurological disorders and cancer.