Details for: CL0000746

Cell ID: CL0000746

Cell Name: cardiac muscle cell

Marker Score Threshold: 13302
(Derived using integrated single-cell and genomic data)

Description: Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.

Synonyms: cardiocyte, cardiac muscle fiber, cardiac myocyte, cardiomyocyte, heart muscle cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 9.75
    Ensembl ID: ENSG00000109846
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 8.87
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 6.67
    Ensembl ID: ENSG00000085224
  • Gene Symbol: NIPSNAP2 (ENSG00000146729)
    Fold Change: 6.25
    Ensembl ID: ENSG00000146729
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 6.09
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 5.67
    Ensembl ID: ENSG00000120907
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 5.22
    Ensembl ID: ENSG00000039537
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 5.11
    Ensembl ID: ENSG00000163288
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 4.97
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 4.88
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 4.72
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CRIP2 (ENSG00000182809)
    Fold Change: 4.39
    Ensembl ID: ENSG00000182809
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 4.17
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 4.11
    Ensembl ID: ENSG00000159251
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 4.09
    Ensembl ID: ENSG00000091138
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 4.04
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.9
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.88
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 3.73
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 3.59
    Ensembl ID: ENSG00000169083
  • Gene Symbol: DLAT (ENSG00000150768)
    Fold Change: 3.44
    Ensembl ID: ENSG00000150768
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.34
    Ensembl ID: ENSG00000111640
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.26
    Ensembl ID: ENSG00000099624
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 3.17
    Ensembl ID: ENSG00000114279
  • Gene Symbol: DARS1 (ENSG00000115866)
    Fold Change: 3.04
    Ensembl ID: ENSG00000115866
  • Gene Symbol: GPC5 (ENSG00000179399)
    Fold Change: 2.92
    Ensembl ID: ENSG00000179399
  • Gene Symbol: FLNA (ENSG00000196924)
    Fold Change: 2.9
    Ensembl ID: ENSG00000196924
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.82
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.65
    Ensembl ID: ENSG00000135390
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 2.65
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.6
    Ensembl ID: ENSG00000116459
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.54
    Ensembl ID: ENSG00000100077
  • Gene Symbol: VEGFD (ENSG00000165197)
    Fold Change: 2.5
    Ensembl ID: ENSG00000165197
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 2.48
    Ensembl ID: ENSG00000104879
  • Gene Symbol: FHL2 (ENSG00000115641)
    Fold Change: 2.45
    Ensembl ID: ENSG00000115641
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.42
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 2.41
    Ensembl ID: ENSG00000154162
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.38
    Ensembl ID: ENSG00000104964
  • Gene Symbol: GABRA4 (ENSG00000109158)
    Fold Change: 2.33
    Ensembl ID: ENSG00000109158
  • Gene Symbol: BCL9 (ENSG00000116128)
    Fold Change: 2.3
    Ensembl ID: ENSG00000116128
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 2.26
    Ensembl ID: ENSG00000178568
  • Gene Symbol: KYAT1 (ENSG00000171097)
    Fold Change: 2.25
    Ensembl ID: ENSG00000171097
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.22
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 2.2
    Ensembl ID: ENSG00000077522
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.18
    Ensembl ID: ENSG00000151067
  • Gene Symbol: FMO5 (ENSG00000131781)
    Fold Change: 2.17
    Ensembl ID: ENSG00000131781
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.14
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CBR3 (ENSG00000159231)
    Fold Change: 2.09
    Ensembl ID: ENSG00000159231
  • Gene Symbol: ATF6B (ENSG00000213676)
    Fold Change: 2.09
    Ensembl ID: ENSG00000213676
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 2.09
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CA1 (ENSG00000133742)
    Fold Change: 2.01
    Ensembl ID: ENSG00000133742
  • Gene Symbol: FABP3 (ENSG00000121769)
    Fold Change: 1.96
    Ensembl ID: ENSG00000121769
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.92
    Ensembl ID: ENSG00000124172
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.78
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165995
  • Gene Symbol: DES (ENSG00000175084)
    Fold Change: 1.75
    Ensembl ID: ENSG00000175084
  • Gene Symbol: CASQ2 (ENSG00000118729)
    Fold Change: 1.72
    Ensembl ID: ENSG00000118729
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.7
    Ensembl ID: ENSG00000170558
  • Gene Symbol: DPP4 (ENSG00000197635)
    Fold Change: 1.7
    Ensembl ID: ENSG00000197635
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.7
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.67
    Ensembl ID: ENSG00000145349
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 1.56
    Ensembl ID: ENSG00000102010
  • Gene Symbol: FBN2 (ENSG00000138829)
    Fold Change: 1.52
    Ensembl ID: ENSG00000138829
  • Gene Symbol: EPRS1 (ENSG00000136628)
    Fold Change: 1.51
    Ensembl ID: ENSG00000136628
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 1.5
    Ensembl ID: ENSG00000150672
  • Gene Symbol: EIF2D (ENSG00000143486)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143486
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.45
    Ensembl ID: ENSG00000151729
  • Gene Symbol: EEF1A2 (ENSG00000101210)
    Fold Change: 1.45
    Ensembl ID: ENSG00000101210
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 1.43
    Ensembl ID: ENSG00000130226
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.41
    Ensembl ID: ENSG00000159216
  • Gene Symbol: GBX1 (ENSG00000164900)
    Fold Change: 1.41
    Ensembl ID: ENSG00000164900
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.4
    Ensembl ID: ENSG00000095139
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 1.38
    Ensembl ID: ENSG00000149806
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.37
    Ensembl ID: ENSG00000090861
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: 1.3
    Ensembl ID: ENSG00000181072
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.29
    Ensembl ID: ENSG00000145362
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.27
    Ensembl ID: ENSG00000127184
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123146
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.24
    Ensembl ID: ENSG00000112297
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.24
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 1.22
    Ensembl ID: ENSG00000257923
  • Gene Symbol: FRG1 (ENSG00000109536)
    Fold Change: 1.21
    Ensembl ID: ENSG00000109536
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196482
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 1.21
    Ensembl ID: ENSG00000134871
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.21
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.19
    Ensembl ID: ENSG00000135940
  • Gene Symbol: DNASE1L1 (ENSG00000013563)
    Fold Change: 1.14
    Ensembl ID: ENSG00000013563
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.13
    Ensembl ID: ENSG00000035687
  • Gene Symbol: FMR1 (ENSG00000102081)
    Fold Change: 1.12
    Ensembl ID: ENSG00000102081
  • Gene Symbol: CDK7 (ENSG00000134058)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134058
  • Gene Symbol: AMPD1 (ENSG00000116748)
    Fold Change: 1.09
    Ensembl ID: ENSG00000116748
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.08
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ATN1 (ENSG00000111676)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111676
  • Gene Symbol: CHRM5 (ENSG00000184984)
    Fold Change: 1.05
    Ensembl ID: ENSG00000184984
  • Gene Symbol: CLCN5 (ENSG00000171365)
    Fold Change: 1.04
    Ensembl ID: ENSG00000171365
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.04
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.02
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.02
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110651
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Striated Muscle Cells**: Cardiac muscle cells are striated muscle cells, meaning they have a striped appearance under a microscope due to the arrangement of their contractile filaments. 2. **Centrally Located Nucleus**: Cardiac muscle cells have a centrally located nucleus, which is distinct from skeletal muscle cells that have a peripheral nucleus. 3. **High Concentration of Sarcoplasm**: Cardiac muscle cells have a high concentration of sarcoplasm, which is the fluid component of the cell that contains the contractile proteins. 4. **Contractile Fiber**: The contractile fiber of cardiac muscle cells is similar to that of skeletal muscle, but is smaller in diameter and has a unique structure. 5. **Gene Expression**: Cardiac muscle cells express a range of genes involved in cardiac function, including those involved in contraction, relaxation, and cell growth. **Genes** 1. **CRYAB**: The gene CRYAB is involved in the regulation of cardiac function and is expressed in cardiac muscle cells. 2. **DDX5**: The gene DDX5 is involved in the regulation of alternative splicing and is expressed in cardiac muscle cells. 3. **ATRX**: The gene ATRX is involved in the regulation of telomere length and is expressed in cardiac muscle cells. 4. **NIPSNAP2**: The gene NIPSNAP2 is involved in the regulation of mitochondrial function and is expressed in cardiac muscle cells. 5. **ACTG1**: The gene ACTG1 is involved in the regulation of actin filament formation and is expressed in cardiac muscle cells. **Clinical Significance** 1. **Cardiac Function**: Cardiac muscle cells play a crucial role in maintaining cardiac function and are essential for the proper functioning of the cardiovascular system. 2. **Cardiac Disease**: Cardiac muscle cells are involved in the development of various cardiac diseases, including heart failure, arrhythmias, and cardiomyopathy. 3. **Regenerative Medicine**: Cardiac muscle cells have the potential to be used for regenerative medicine, including the treatment of cardiac disease. 4. **Stem Cell Research**: Cardiac muscle cells are of interest in stem cell research, as they have the potential to be used for the generation of new cardiac tissue. **Potential Applications** 1. **Cardiac Regeneration**: Cardiac muscle cells have the potential to be used for cardiac regeneration, including the treatment of cardiac disease. 2. **Stem Cell Therapy**: Cardiac muscle cells have the potential to be used for stem cell therapy, including the treatment of cardiac disease. 3. **Tissue Engineering**: Cardiac muscle cells have the potential to be used for tissue engineering, including the creation of artificial cardiac tissue. 4. **Gene Therapy**: Cardiac muscle cells have the potential to be used for gene therapy, including the treatment of genetic disorders. In conclusion, cardiac muscle cells are a unique type of striated muscle cell that play a crucial role in maintaining cardiac function. They have a range of genes involved in cardiac function and have the potential to be used for regenerative medicine, stem cell research, tissue engineering, and gene therapy.