Details for: CL0000749

Cell ID: CL0000749

Cell Name: ON-bipolar cell

Marker Score Threshold: 2916
(Derived using integrated single-cell and genomic data)

Description: A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CRYAA (ENSG00000160202)
    Fold Change: 9.42
    Ensembl ID: ENSG00000160202
  • Gene Symbol: GML (ENSG00000104499)
    Fold Change: 7.69
    Ensembl ID: ENSG00000104499
  • Gene Symbol: IL12RB2 (ENSG00000081985)
    Fold Change: 6.86
    Ensembl ID: ENSG00000081985
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 6.81
    Ensembl ID: ENSG00000108839
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 6.66
    Ensembl ID: ENSG00000039537
  • Gene Symbol: PLN (ENSG00000198523)
    Fold Change: 6.43
    Ensembl ID: ENSG00000198523
  • Gene Symbol: COL10A1 (ENSG00000123500)
    Fold Change: 6.27
    Ensembl ID: ENSG00000123500
  • Gene Symbol: MUC6 (ENSG00000184956)
    Fold Change: 6.23
    Ensembl ID: ENSG00000184956
  • Gene Symbol: SERPINB2 (ENSG00000197632)
    Fold Change: 6.18
    Ensembl ID: ENSG00000197632
  • Gene Symbol: FLT3 (ENSG00000122025)
    Fold Change: 6.11
    Ensembl ID: ENSG00000122025
  • Gene Symbol: CA1 (ENSG00000133742)
    Fold Change: 6.05
    Ensembl ID: ENSG00000133742
  • Gene Symbol: OMD (ENSG00000127083)
    Fold Change: 6.03
    Ensembl ID: ENSG00000127083
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 5.97
    Ensembl ID: ENSG00000075673
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 5.9
    Ensembl ID: ENSG00000091138
  • Gene Symbol: MUSK (ENSG00000030304)
    Fold Change: 5.82
    Ensembl ID: ENSG00000030304
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 5.79
    Ensembl ID: ENSG00000104879
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 5.78
    Ensembl ID: ENSG00000102010
  • Gene Symbol: CAV3 (ENSG00000182533)
    Fold Change: 5.76
    Ensembl ID: ENSG00000182533
  • Gene Symbol: CDK3 (ENSG00000250506)
    Fold Change: 5.76
    Ensembl ID: ENSG00000250506
  • Gene Symbol: SERPIND1 (ENSG00000099937)
    Fold Change: 5.75
    Ensembl ID: ENSG00000099937
  • Gene Symbol: ITIH2 (ENSG00000151655)
    Fold Change: 5.74
    Ensembl ID: ENSG00000151655
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 5.66
    Ensembl ID: ENSG00000002726
  • Gene Symbol: NODAL (ENSG00000156574)
    Fold Change: 5.65
    Ensembl ID: ENSG00000156574
  • Gene Symbol: GPR39 (ENSG00000183840)
    Fold Change: 5.62
    Ensembl ID: ENSG00000183840
  • Gene Symbol: CPB2 (ENSG00000080618)
    Fold Change: 5.61
    Ensembl ID: ENSG00000080618
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 5.59
    Ensembl ID: ENSG00000110448
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 5.56
    Ensembl ID: ENSG00000124813
  • Gene Symbol: OGN (ENSG00000106809)
    Fold Change: 5.55
    Ensembl ID: ENSG00000106809
  • Gene Symbol: GATA1 (ENSG00000102145)
    Fold Change: 5.54
    Ensembl ID: ENSG00000102145
  • Gene Symbol: LMX1B (ENSG00000136944)
    Fold Change: 5.53
    Ensembl ID: ENSG00000136944
  • Gene Symbol: CYP3A7 (ENSG00000160870)
    Fold Change: 5.53
    Ensembl ID: ENSG00000160870
  • Gene Symbol: CFTR (ENSG00000001626)
    Fold Change: 5.49
    Ensembl ID: ENSG00000001626
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 5.37
    Ensembl ID: ENSG00000118520
  • Gene Symbol: IL5 (ENSG00000113525)
    Fold Change: 5.37
    Ensembl ID: ENSG00000113525
  • Gene Symbol: ERG (ENSG00000157554)
    Fold Change: 5.29
    Ensembl ID: ENSG00000157554
  • Gene Symbol: NELL1 (ENSG00000165973)
    Fold Change: 5.13
    Ensembl ID: ENSG00000165973
  • Gene Symbol: IL7 (ENSG00000104432)
    Fold Change: 5.12
    Ensembl ID: ENSG00000104432
  • Gene Symbol: PFKFB1 (ENSG00000158571)
    Fold Change: 5.08
    Ensembl ID: ENSG00000158571
  • Gene Symbol: EVC (ENSG00000072840)
    Fold Change: 4.98
    Ensembl ID: ENSG00000072840
  • Gene Symbol: CRYBA1 (ENSG00000108255)
    Fold Change: 4.96
    Ensembl ID: ENSG00000108255
  • Gene Symbol: GPR18 (ENSG00000125245)
    Fold Change: 4.79
    Ensembl ID: ENSG00000125245
  • Gene Symbol: FSHR (ENSG00000170820)
    Fold Change: 4.38
    Ensembl ID: ENSG00000170820
  • Gene Symbol: POU4F1 (ENSG00000152192)
    Fold Change: 4.37
    Ensembl ID: ENSG00000152192
  • Gene Symbol: GBX1 (ENSG00000164900)
    Fold Change: 4.29
    Ensembl ID: ENSG00000164900
  • Gene Symbol: DIO1 (ENSG00000211452)
    Fold Change: 4.21
    Ensembl ID: ENSG00000211452
  • Gene Symbol: HPD (ENSG00000158104)
    Fold Change: 3.98
    Ensembl ID: ENSG00000158104
  • Gene Symbol: CNGA4 (ENSG00000132259)
    Fold Change: 3.96
    Ensembl ID: ENSG00000132259
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.77
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ENPEP (ENSG00000138792)
    Fold Change: 3.7
    Ensembl ID: ENSG00000138792
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 3.65
    Ensembl ID: ENSG00000198938
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 3.65
    Ensembl ID: ENSG00000198886
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 3.65
    Ensembl ID: ENSG00000198727
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 3.64
    Ensembl ID: ENSG00000198804
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 3.63
    Ensembl ID: ENSG00000198899
  • Gene Symbol: CDC25C (ENSG00000158402)
    Fold Change: 3.62
    Ensembl ID: ENSG00000158402
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 3.6
    Ensembl ID: ENSG00000198712
  • Gene Symbol: LHCGR (ENSG00000138039)
    Fold Change: 3.6
    Ensembl ID: ENSG00000138039
  • Gene Symbol: F11 (ENSG00000088926)
    Fold Change: 3.58
    Ensembl ID: ENSG00000088926
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 3.57
    Ensembl ID: ENSG00000198840
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 3.57
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 3.57
    Ensembl ID: ENSG00000198763
  • Gene Symbol: FLG (ENSG00000143631)
    Fold Change: 3.52
    Ensembl ID: ENSG00000143631
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 3.3
    Ensembl ID: ENSG00000198786
  • Gene Symbol: CCR3 (ENSG00000183625)
    Fold Change: 3.28
    Ensembl ID: ENSG00000183625
  • Gene Symbol: FAT2 (ENSG00000086570)
    Fold Change: 3.19
    Ensembl ID: ENSG00000086570
  • Gene Symbol: MEOX1 (ENSG00000005102)
    Fold Change: 2.92
    Ensembl ID: ENSG00000005102
  • Gene Symbol: DOCK2 (ENSG00000134516)
    Fold Change: 2.89
    Ensembl ID: ENSG00000134516
  • Gene Symbol: SERPINI2 (ENSG00000114204)
    Fold Change: 2.83
    Ensembl ID: ENSG00000114204
  • Gene Symbol: HNF4G (ENSG00000164749)
    Fold Change: 2.77
    Ensembl ID: ENSG00000164749
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.64
    Ensembl ID: ENSG00000168028
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 2.62
    Ensembl ID: ENSG00000198755
  • Gene Symbol: CYP3A4 (ENSG00000160868)
    Fold Change: 2.6
    Ensembl ID: ENSG00000160868
  • Gene Symbol: DRD3 (ENSG00000151577)
    Fold Change: 2.58
    Ensembl ID: ENSG00000151577
  • Gene Symbol: PIK3C2G (ENSG00000139144)
    Fold Change: 2.5
    Ensembl ID: ENSG00000139144
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.37
    Ensembl ID: ENSG00000212907
  • Gene Symbol: GABRA5 (ENSG00000186297)
    Fold Change: 2.29
    Ensembl ID: ENSG00000186297
  • Gene Symbol: IL5RA (ENSG00000091181)
    Fold Change: 2.24
    Ensembl ID: ENSG00000091181
  • Gene Symbol: FPR2 (ENSG00000171049)
    Fold Change: 2.21
    Ensembl ID: ENSG00000171049
  • Gene Symbol: PLG (ENSG00000122194)
    Fold Change: 2.02
    Ensembl ID: ENSG00000122194
  • Gene Symbol: CRYBB1 (ENSG00000100122)
    Fold Change: 1.96
    Ensembl ID: ENSG00000100122
  • Gene Symbol: DNAH8 (ENSG00000124721)
    Fold Change: 1.91
    Ensembl ID: ENSG00000124721
  • Gene Symbol: ARSL (ENSG00000157399)
    Fold Change: 1.79
    Ensembl ID: ENSG00000157399
  • Gene Symbol: IL3RA (ENSG00000185291)
    Fold Change: 1.68
    Ensembl ID: ENSG00000185291
  • Gene Symbol: NR5A2 (ENSG00000116833)
    Fold Change: 1.61
    Ensembl ID: ENSG00000116833
  • Gene Symbol: GYPB (ENSG00000250361)
    Fold Change: 1.52
    Ensembl ID: ENSG00000250361
  • Gene Symbol: HTR2C (ENSG00000147246)
    Fold Change: 1.52
    Ensembl ID: ENSG00000147246
  • Gene Symbol: HTR4 (ENSG00000164270)
    Fold Change: 1.49
    Ensembl ID: ENSG00000164270
  • Gene Symbol: GUCY2C (ENSG00000070019)
    Fold Change: 1.25
    Ensembl ID: ENSG00000070019
  • Gene Symbol: CHI3L2 (ENSG00000064886)
    Fold Change: 1.25
    Ensembl ID: ENSG00000064886
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.23
    Ensembl ID: ENSG00000196433
  • Gene Symbol: HCRTR1 (ENSG00000121764)
    Fold Change: 1.23
    Ensembl ID: ENSG00000121764
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.21
    Ensembl ID: ENSG00000012779
  • Gene Symbol: NMBR (ENSG00000135577)
    Fold Change: 1.2
    Ensembl ID: ENSG00000135577
  • Gene Symbol: KNG1 (ENSG00000113889)
    Fold Change: 1.16
    Ensembl ID: ENSG00000113889
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.1
    Ensembl ID: ENSG00000075624
  • Gene Symbol: IDO1 (ENSG00000131203)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131203
  • Gene Symbol: CEACAM8 (ENSG00000124469)
    Fold Change: 1.04
    Ensembl ID: ENSG00000124469
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.03
    Ensembl ID: ENSG00000161798
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.03
    Ensembl ID: ENSG00000156508
  • Gene Symbol: PRB1 (ENSG00000251655)
    Fold Change: 1.02
    Ensembl ID: ENSG00000251655
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type**: ON-bipolar cell, a type of bipolar neuron found in the retina. * **Location**: Inner half of the inner plexiform layer of the retina. * **Function**: Responds to light stimulation by depolarizing. * **Genes**: + CRYAA: involved in visual perception. + GML: involved in apoptosis and negative regulation of the apoptotic process. + IL12RB2: involved in immune response and cytokine signaling. * **Proteins**: + ALOX12: involved in lipid metabolism. + C6: involved in complement activation. + PLN: involved in cardiac muscle contraction. + COL10A1: involved in collagen formation. + MUC6: involved in extracellular matrix organization. **Clinical Significance** * **Visual Impairment**: Alterations in the expression of CRYAA, GML, and IL12RB2 genes may contribute to visual impairment. * **Immune System**: Alterations in the expression of IL12RB2 and GML genes may affect the immune system's response to pathogens. * **Cardiac Muscle**: Alterations in the expression of PLN gene may affect cardiac muscle contraction and relaxation. * **Collagen Disorders**: Alterations in the expression of COL10A1 gene may contribute to collagen disorders such as osteogenesis imperfecta. * **Gastrointestinal Disorders**: Alterations in the expression of MUC6 gene may contribute to gastrointestinal disorders such as inflammatory bowel disease. In conclusion, the ON-bipolar cell is a complex cell type that responds to light stimulation and is involved in various cellular processes. The expression of different genes and proteins in this cell type suggests a complex interplay between different cellular processes, and alterations in the expression of these genes and proteins may contribute to various diseases.