Details for: CL0000750

Cell ID: CL0000750

Cell Name: OFF-bipolar cell

Marker Score Threshold: 2966
(Derived using integrated single-cell and genomic data)

Description: A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolarize in response to light to dark transition.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CRYAA (ENSG00000160202)
    Fold Change: 8.52
    Ensembl ID: ENSG00000160202
  • Gene Symbol: CRHR1 (ENSG00000120088)
    Fold Change: 6.81
    Ensembl ID: ENSG00000120088
  • Gene Symbol: GML (ENSG00000104499)
    Fold Change: 6.44
    Ensembl ID: ENSG00000104499
  • Gene Symbol: IL12RB2 (ENSG00000081985)
    Fold Change: 6.01
    Ensembl ID: ENSG00000081985
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 5.91
    Ensembl ID: ENSG00000108839
  • Gene Symbol: CBS (ENSG00000160200)
    Fold Change: 5.83
    Ensembl ID: ENSG00000160200
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 5.71
    Ensembl ID: ENSG00000039537
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 5.69
    Ensembl ID: ENSG00000104879
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 5.68
    Ensembl ID: ENSG00000075673
  • Gene Symbol: ITIH2 (ENSG00000151655)
    Fold Change: 5.6
    Ensembl ID: ENSG00000151655
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 5.58
    Ensembl ID: ENSG00000160683
  • Gene Symbol: MEP1B (ENSG00000141434)
    Fold Change: 5.52
    Ensembl ID: ENSG00000141434
  • Gene Symbol: COL10A1 (ENSG00000123500)
    Fold Change: 5.49
    Ensembl ID: ENSG00000123500
  • Gene Symbol: MECOM (ENSG00000085276)
    Fold Change: 5.47
    Ensembl ID: ENSG00000085276
  • Gene Symbol: CA1 (ENSG00000133742)
    Fold Change: 5.42
    Ensembl ID: ENSG00000133742
  • Gene Symbol: GHR (ENSG00000112964)
    Fold Change: 5.42
    Ensembl ID: ENSG00000112964
  • Gene Symbol: ITGA5 (ENSG00000161638)
    Fold Change: 5.34
    Ensembl ID: ENSG00000161638
  • Gene Symbol: FLT3 (ENSG00000122025)
    Fold Change: 5.31
    Ensembl ID: ENSG00000122025
  • Gene Symbol: CLC (ENSG00000105205)
    Fold Change: 5.26
    Ensembl ID: ENSG00000105205
  • Gene Symbol: GPR34 (ENSG00000171659)
    Fold Change: 5.21
    Ensembl ID: ENSG00000171659
  • Gene Symbol: CRYBA1 (ENSG00000108255)
    Fold Change: 5.19
    Ensembl ID: ENSG00000108255
  • Gene Symbol: CAV3 (ENSG00000182533)
    Fold Change: 5.16
    Ensembl ID: ENSG00000182533
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 5.16
    Ensembl ID: ENSG00000102010
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 5.07
    Ensembl ID: ENSG00000091138
  • Gene Symbol: KEL (ENSG00000197993)
    Fold Change: 5
    Ensembl ID: ENSG00000197993
  • Gene Symbol: ASIP (ENSG00000101440)
    Fold Change: 4.98
    Ensembl ID: ENSG00000101440
  • Gene Symbol: EDA (ENSG00000158813)
    Fold Change: 4.95
    Ensembl ID: ENSG00000158813
  • Gene Symbol: CLDN4 (ENSG00000189143)
    Fold Change: 4.94
    Ensembl ID: ENSG00000189143
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 4.92
    Ensembl ID: ENSG00000124813
  • Gene Symbol: CDK3 (ENSG00000250506)
    Fold Change: 4.92
    Ensembl ID: ENSG00000250506
  • Gene Symbol: CPB2 (ENSG00000080618)
    Fold Change: 4.92
    Ensembl ID: ENSG00000080618
  • Gene Symbol: MSH4 (ENSG00000057468)
    Fold Change: 4.92
    Ensembl ID: ENSG00000057468
  • Gene Symbol: CFTR (ENSG00000001626)
    Fold Change: 4.91
    Ensembl ID: ENSG00000001626
  • Gene Symbol: SERPIND1 (ENSG00000099937)
    Fold Change: 4.91
    Ensembl ID: ENSG00000099937
  • Gene Symbol: MLANA (ENSG00000120215)
    Fold Change: 4.85
    Ensembl ID: ENSG00000120215
  • Gene Symbol: GATA1 (ENSG00000102145)
    Fold Change: 4.84
    Ensembl ID: ENSG00000102145
  • Gene Symbol: CR1L (ENSG00000197721)
    Fold Change: 4.83
    Ensembl ID: ENSG00000197721
  • Gene Symbol: EVC (ENSG00000072840)
    Fold Change: 4.74
    Ensembl ID: ENSG00000072840
  • Gene Symbol: ECM2 (ENSG00000106823)
    Fold Change: 4.71
    Ensembl ID: ENSG00000106823
  • Gene Symbol: IL16 (ENSG00000172349)
    Fold Change: 4.56
    Ensembl ID: ENSG00000172349
  • Gene Symbol: FBN2 (ENSG00000138829)
    Fold Change: 4.47
    Ensembl ID: ENSG00000138829
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 4.34
    Ensembl ID: ENSG00000002726
  • Gene Symbol: DIO1 (ENSG00000211452)
    Fold Change: 4.25
    Ensembl ID: ENSG00000211452
  • Gene Symbol: DNAH8 (ENSG00000124721)
    Fold Change: 4.2
    Ensembl ID: ENSG00000124721
  • Gene Symbol: CYP3A7 (ENSG00000160870)
    Fold Change: 4.17
    Ensembl ID: ENSG00000160870
  • Gene Symbol: F11 (ENSG00000088926)
    Fold Change: 4.15
    Ensembl ID: ENSG00000088926
  • Gene Symbol: IL5 (ENSG00000113525)
    Fold Change: 4.12
    Ensembl ID: ENSG00000113525
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 4.1
    Ensembl ID: ENSG00000118520
  • Gene Symbol: GPR18 (ENSG00000125245)
    Fold Change: 4.1
    Ensembl ID: ENSG00000125245
  • Gene Symbol: FAT2 (ENSG00000086570)
    Fold Change: 4.05
    Ensembl ID: ENSG00000086570
  • Gene Symbol: GBX1 (ENSG00000164900)
    Fold Change: 3.93
    Ensembl ID: ENSG00000164900
  • Gene Symbol: HPD (ENSG00000158104)
    Fold Change: 3.64
    Ensembl ID: ENSG00000158104
  • Gene Symbol: DPP4 (ENSG00000197635)
    Fold Change: 3.62
    Ensembl ID: ENSG00000197635
  • Gene Symbol: LMX1B (ENSG00000136944)
    Fold Change: 3.59
    Ensembl ID: ENSG00000136944
  • Gene Symbol: LTBP1 (ENSG00000049323)
    Fold Change: 3.53
    Ensembl ID: ENSG00000049323
  • Gene Symbol: GCNT1 (ENSG00000187210)
    Fold Change: 3.37
    Ensembl ID: ENSG00000187210
  • Gene Symbol: EYA4 (ENSG00000112319)
    Fold Change: 3.16
    Ensembl ID: ENSG00000112319
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 3.14
    Ensembl ID: ENSG00000145692
  • Gene Symbol: GPER1 (ENSG00000164850)
    Fold Change: 3.11
    Ensembl ID: ENSG00000164850
  • Gene Symbol: DRD3 (ENSG00000151577)
    Fold Change: 2.94
    Ensembl ID: ENSG00000151577
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.81
    Ensembl ID: ENSG00000198804
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198938
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.78
    Ensembl ID: ENSG00000198899
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.78
    Ensembl ID: ENSG00000198727
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.75
    Ensembl ID: ENSG00000198712
  • Gene Symbol: CACNA1S (ENSG00000081248)
    Fold Change: 2.58
    Ensembl ID: ENSG00000081248
  • Gene Symbol: CNGA4 (ENSG00000132259)
    Fold Change: 2.58
    Ensembl ID: ENSG00000132259
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.57
    Ensembl ID: ENSG00000169100
  • Gene Symbol: MEOX1 (ENSG00000005102)
    Fold Change: 2.49
    Ensembl ID: ENSG00000005102
  • Gene Symbol: FSHR (ENSG00000170820)
    Fold Change: 2.43
    Ensembl ID: ENSG00000170820
  • Gene Symbol: MPL (ENSG00000117400)
    Fold Change: 2.41
    Ensembl ID: ENSG00000117400
  • Gene Symbol: CSF1R (ENSG00000182578)
    Fold Change: 2.3
    Ensembl ID: ENSG00000182578
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.26
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ERG (ENSG00000157554)
    Fold Change: 2.26
    Ensembl ID: ENSG00000157554
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.07
    Ensembl ID: ENSG00000168028
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 2.04
    Ensembl ID: ENSG00000184254
  • Gene Symbol: FLG (ENSG00000143631)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143631
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.8
    Ensembl ID: ENSG00000012779
  • Gene Symbol: COL13A1 (ENSG00000197467)
    Fold Change: 1.8
    Ensembl ID: ENSG00000197467
  • Gene Symbol: HK3 (ENSG00000160883)
    Fold Change: 1.77
    Ensembl ID: ENSG00000160883
  • Gene Symbol: F5 (ENSG00000198734)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198734
  • Gene Symbol: GLI2 (ENSG00000074047)
    Fold Change: 1.41
    Ensembl ID: ENSG00000074047
  • Gene Symbol: HCRTR1 (ENSG00000121764)
    Fold Change: 1.38
    Ensembl ID: ENSG00000121764
  • Gene Symbol: BRDT (ENSG00000137948)
    Fold Change: 1.36
    Ensembl ID: ENSG00000137948
  • Gene Symbol: CBLIF (ENSG00000134812)
    Fold Change: 1.33
    Ensembl ID: ENSG00000134812
  • Gene Symbol: HTR1E (ENSG00000168830)
    Fold Change: 1.24
    Ensembl ID: ENSG00000168830
  • Gene Symbol: DOCK2 (ENSG00000134516)
    Fold Change: 1.19
    Ensembl ID: ENSG00000134516
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 1.16
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087086
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.16
    Ensembl ID: ENSG00000156508
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 1.13
    Ensembl ID: ENSG00000132475
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.12
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CDH17 (ENSG00000079112)
    Fold Change: 1.1
    Ensembl ID: ENSG00000079112
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149806
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 1.09
    Ensembl ID: ENSG00000080824
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 1.06
    Ensembl ID: ENSG00000111640
  • Gene Symbol: IL5RA (ENSG00000091181)
    Fold Change: 1.05
    Ensembl ID: ENSG00000091181
  • Gene Symbol: CRYBB1 (ENSG00000100122)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100122
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122566
  • Gene Symbol: CYP3A4 (ENSG00000160868)
    Fold Change: 1.01
    Ensembl ID: ENSG00000160868
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location and Function**: The OFF-bipolar cell is located in the retina and is connected to photoreceptors and neurons in the outer half of the inner plexiform layer. Its primary function is to transmit visual information from photoreceptors to ganglion cells. 2. **Gene Expression**: The OFF-bipolar cell expresses a unique set of genes, including CRYAA, CRHR1, GML, IL12RB2, ALOX12, CBS, C6, CKM, and ATP12A. These genes are involved in visual perception, immune response, cellular stress response, and other cellular processes. 3. **Depolarization Response**: The OFF-bipolar cell depolarizes in response to light-dark transition, which is essential for visual perception. 4. **Connection to Photoreceptors**: The OFF-bipolar cell is connected to photoreceptors through synapses, allowing it to transmit visual information from photoreceptors to ganglion cells. 5. **Connection to Neurons in the Outer Half of the Inner Plexiform Layer**: The OFF-bipolar cell is connected to neurons in the outer half of the inner plexiform layer, which is involved in the transmission of visual information to higher-level visual processing centers. **Clinical Significance** 1. **Visual Perception**: The OFF-bipolar cell plays a crucial role in visual perception, and its dysfunction can lead to visual impairments or blindness. 2. **Immune Response**: The OFF-bipolar cell expresses genes involved in the immune response, such as IL12RB2, which is involved in the regulation of immune cell activity. 3. **Cellular Stress Response**: The OFF-bipolar cell expresses genes involved in the cellular stress response, such as GML, which is involved in the regulation of cellular stress responses. 4. **Disease Association**: The OFF-bipolar cell has been associated with various diseases, including retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy. 5. **Therapeutic Potential**: Understanding the OFF-bipolar cell's function and gene expression profile may provide new therapeutic targets for the treatment of visual impairments and diseases associated with the OFF-bipolar cell. In conclusion, the OFF-bipolar cell is a complex and multifunctional neuron that plays a crucial role in visual perception and immune response. Its unique gene expression profile and connection to photoreceptors and neurons in the outer half of the inner plexiform layer make it an important target for further research and potential therapeutic interventions.