Details for: CL0000751

Cell ID: CL0000751

Cell Name: rod bipolar cell

Marker Score Threshold: 522
(Derived using integrated single-cell and genomic data)

Description: A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.81
    Ensembl ID: ENSG00000198668
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.6
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.46
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.46
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.11
    Ensembl ID: ENSG00000075624
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.05
    Ensembl ID: ENSG00000151914
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 3.04
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.95
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.88
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.87
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.8
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.77
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 2.72
    Ensembl ID: ENSG00000173208
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.6
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.5
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.23
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 2.2
    Ensembl ID: ENSG00000058404
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.15
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.07
    Ensembl ID: ENSG00000140836
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: 1.99
    Ensembl ID: ENSG00000129673
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.98
    Ensembl ID: ENSG00000129244
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.93
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.9
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.88
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.87
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.87
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.86
    Ensembl ID: ENSG00000105409
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.85
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.83
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.8
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.76
    Ensembl ID: ENSG00000110955
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.73
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.72
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.72
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.71
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.7
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.69
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 1.63
    Ensembl ID: ENSG00000178538
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.63
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.6
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.6
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.53
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.52
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.52
    Ensembl ID: ENSG00000241837
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.49
    Ensembl ID: ENSG00000130294
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.48
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.48
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.46
    Ensembl ID: ENSG00000159199
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.46
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.44
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.42
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CACNA1F (ENSG00000102001)
    Fold Change: 1.4
    Ensembl ID: ENSG00000102001
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.38
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.35
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.27
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.26
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.26
    Ensembl ID: ENSG00000117054
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.25
    Ensembl ID: ENSG00000151729
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.25
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP6V1G2 (ENSG00000213760)
    Fold Change: 1.24
    Ensembl ID: ENSG00000213760
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.23
    Ensembl ID: ENSG00000149311
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.23
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.22
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.21
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.19
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.18
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 1.18
    Ensembl ID: ENSG00000109107
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.17
    Ensembl ID: ENSG00000213465
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.17
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.15
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.08
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.08
    Ensembl ID: ENSG00000136717
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131100
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.07
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.06
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.06
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.04
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1
    Ensembl ID: ENSG00000072778
Hovered Details

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Hovered Details

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**Key Characteristics** The CL0000751 cell is a bipolar neuron that: 1. **Depolarizes in response to light**: The cell's depolarization response to light is mediated by the activation of phototransduction cascades, which involve the binding of light to rhodopsin in rod photoreceptor cells. 2. **Is synapsed by rod photoreceptor cells**: The CL0000751 cell is synapsed by rod photoreceptor cells, which provide the necessary input for the cell's depolarization response. 3. **Has a unique gene expression profile**: The CL0000751 cell's gene expression profile is characterized by the presence of genes involved in calcium signaling, neuronal development, and synaptic transmission. 4. **Involves multiple signaling pathways**: The CL0000751 cell's signaling pathways are complex and involve the activation of AMPA receptors, NMDA receptors, and Ca-permeable kainate receptors. 5. **Is involved in retinal development and function**: The CL0000751 cell plays a crucial role in retinal development and function, particularly in the context of visual phototransduction. **Clinical Significance** The CL0000751 cell has significant clinical significance, particularly in the context of retinal diseases and disorders, such as: 1. **Leber congenital amaurosis**: A genetic disorder that affects the development of the retina and leads to severe visual impairment. 2. **Retinitis pigmentosa**: A group of genetic disorders that affect the retina and lead to progressive visual loss. 3. **Retinal degeneration**: A condition characterized by the degeneration of retinal cells, including photoreceptors, bipolar cells, and ganglion cells. 4. **Visual impairment**: The CL0000751 cell's dysfunction can lead to visual impairment, including blurred vision, loss of peripheral vision, and night blindness. In summary, the CL0000751 cell is a critical component of the visual system, and its dysfunction can lead to significant clinical consequences. Further research is needed to understand the molecular mechanisms underlying the CL0000751 cell's function and dysfunction, and to develop effective treatments for retinal diseases and disorders.