Details for: CL0000776

Cell ID: CL0000776

Cell Name: immature neutrophil

Marker Score Threshold: 338
(Derived using integrated single-cell and genomic data)

Description: Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking.

Synonyms: immatuer neutrophilic leukocyte, immature neutrocyte, immature neutrophil leucocyte, immature neutrophil leukocyte, immature neutrophilic leucocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.3
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.89
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.83
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.81
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.61
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.48
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.43
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.26
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.25
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.2
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.17
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.07
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.07
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.99
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.94
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.92
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.89
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.88
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.85
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.84
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.79
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.73
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.71
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.71
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.7
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.69
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.64
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.63
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.62
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.6
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.52
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.51
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.5
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.5
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.49
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.49
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.49
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.48
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.47
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.47
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.47
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.47
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.45
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.39
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.38
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.37
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.36
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.34
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.34
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.32
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.31
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.31
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.31
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.31
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.29
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.28
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.28
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.27
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.23
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.23
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.23
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.22
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.18
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.17
    Ensembl ID: ENSG00000112576
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.15
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.14
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.14
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.12
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.09
    Ensembl ID: ENSG00000107262
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.08
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.08
    Ensembl ID: ENSG00000126247
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.05
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.02
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.01
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162909
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.01
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.01
    Ensembl ID: ENSG00000085063
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1
    Ensembl ID: ENSG00000006125
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1
    Ensembl ID: ENSG00000149823
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Immunophenotype**: Immature neutrophils express specific surface markers, such as CD16/32, CD11b, and CD14, which are characteristic of neutrophils. 2. **Granule formation**: Immature neutrophils contain specific granules, known as azurophilic granules, which are involved in the release of antimicrobial peptides and enzymes. 3. **Cell shape and size**: Immature neutrophils are typically larger and more irregular in shape than mature neutrophils. 4. **Cytoskeletal organization**: Immature neutrophils have a more disorganized cytoskeleton, which is essential for their ability to migrate and phagocytose. 5. **Gene expression**: Immature neutrophils express a unique set of genes, including those involved in the regulation of cell adhesion, migration, and phagocytosis. **Clinical Significance** 1. **Infections**: Immature neutrophils play a crucial role in the defense against infections, particularly those caused by Gram-negative bacteria. 2. **Inflammatory responses**: Immature neutrophils are involved in the regulation of inflammatory responses, including the release of cytokines and chemokines. 3. **Cancer**: Immature neutrophils have been implicated in the development and progression of various cancers, including leukemia and lymphoma. 4. **Neurological disorders**: Immature neutrophils have been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 5. **Immunodeficiency diseases**: Immature neutrophils are essential for the development and function of the innate immune system, and defects in their development or function can lead to immunodeficiency diseases. **Pathways and Ontologies** 1. **Adherens junction**: Immature neutrophils are involved in the regulation of adherens junctions, which are essential for cell adhesion and migration. 2. **Apical junction complex**: Immature neutrophils contain apical junction complexes, which are involved in the regulation of cell polarity and migration. 3. **Apoptosis**: Immature neutrophils are involved in the regulation of apoptosis, which is essential for the development and function of the immune system. 4. **Cell-cell communication**: Immature neutrophils are involved in the regulation of cell-cell communication, including the release of cytokines and chemokines. 5. **Cytoskeleton organization**: Immature neutrophils are involved in the regulation of cytoskeletal organization, which is essential for cell migration and phagocytosis. In conclusion, immature neutrophils are essential for the development and function of the innate immune system, and their dysregulation can lead to a range of clinical disorders. Further research is needed to fully understand the biology and pathogenesis of immature neutrophils.