Details for: CL0000782

Cell ID: CL0000782

Cell Name: myeloid dendritic cell

Marker Score Threshold: 607
(Derived using integrated single-cell and genomic data)

Description: A dendritic cell of the myeloid lineage.

Synonyms: interdigitating cell, veiled cell, CD11c+CD123- DC, mDC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 5.07
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 4.85
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.78
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.73
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.65
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.59
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 4.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.58
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 4.55
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 4.43
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 4.36
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 4.12
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 4.11
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 4.05
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 4.03
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 3.62
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 3.54
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CD68 (ENSG00000129226)
    Fold Change: 3.35
    Ensembl ID: ENSG00000129226
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 3.16
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.96
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.84
    Ensembl ID: ENSG00000169020
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.83
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 2.8
    Ensembl ID: ENSG00000248098
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.75
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 2.74
    Ensembl ID: ENSG00000123146
  • Gene Symbol: CD4 (ENSG00000010610)
    Fold Change: 2.62
    Ensembl ID: ENSG00000010610
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.59
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 2.53
    Ensembl ID: ENSG00000089820
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.44
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 2.39
    Ensembl ID: ENSG00000010671
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 2.16
    Ensembl ID: ENSG00000012779
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.05
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.02
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.97
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.97
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.87
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.83
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.82
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.74
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.73
    Ensembl ID: ENSG00000112297
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.65
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.65
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.64
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.61
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.58
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.58
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.56
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.53
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.52
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.47
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.43
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116489
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.39
    Ensembl ID: ENSG00000173020
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.39
    Ensembl ID: ENSG00000142188
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.34
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.31
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.3
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.29
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.28
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.25
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.21
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.2
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.17
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.17
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.15
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.15
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.14
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.13
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.12
    Ensembl ID: ENSG00000026508
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.1
    Ensembl ID: ENSG00000163399
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.09
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.09
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.09
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.06
    Ensembl ID: ENSG00000069849
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.05
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.03
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: N/A
    Ensembl ID: ENSG00000140299
Hovered Details

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Hovered Details

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**Key Characteristics** Myeloid dendritic cells are characterized by several key features, including: 1. **Expression of specific surface markers**: Myeloid dendritic cells express specific surface markers, such as CD11c and CD123, which help to identify them. 2. **Presence of phagocytic cup**: Myeloid dendritic cells have a phagocytic cup, which is a specialized structure that allows them to engulf and internalize antigens. 3. **Ability to produce cytokines**: Myeloid dendritic cells are capable of producing a wide range of cytokines, including IL-6, IL-12, and TNF-α, which help to regulate immune responses. 4. **Expression of ATP6V0C**: Myeloid dendritic cells express ATP6V0C, a gene that encodes for a protein involved in the regulation of gene expression. 5. **Role in immune responses**: Myeloid dendritic cells play a key role in the initiation of immune responses, including the activation of T-cells and the production of cytokines. **Clinical Significance** Myeloid dendritic cells have several clinical significance, including: 1. **Immunotherapy**: Myeloid dendritic cells have been used as a vaccine vector to stimulate the immune system against cancer cells. 2. **Autoimmune diseases**: Myeloid dendritic cells have been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious diseases**: Myeloid dendritic cells play a key role in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. 4. **Cancer**: Myeloid dendritic cells have been shown to play a role in the progression of cancer, including the activation of tumor-associated immune cells. 5. **Vaccine development**: Myeloid dendritic cells have been used as a model system to study the development of vaccines against infectious diseases and cancer. In conclusion, myeloid dendritic cells are a type of dendritic cell that plays a key role in the regulation of immune responses. Their ability to produce cytokines, express specific surface markers, and engulf antigens make them an important component of the immune system. Their clinical significance extends to the development of immunotherapies, the study of autoimmune diseases, and the understanding of cancer progression.