Details for: CL0000785

Cell ID: CL0000785

Cell Name: mature B cell

Marker Score Threshold: 733
(Derived using integrated single-cell and genomic data)

Description: A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen.

Synonyms: mature B lymphocyte, mature B-cell, mature B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.4
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.27
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.25
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.22
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.13
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.13
    Ensembl ID: ENSG00000154518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.13
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.11
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.09
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.97
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.96
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.92
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.89
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.88
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.88
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.86
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.85
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.83
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.65
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.63
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.62
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.61
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.59
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.57
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.56
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.55
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.53
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.52
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.52
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.49
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.49
    Ensembl ID: ENSG00000117091
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.48
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.47
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.46
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.45
    Ensembl ID: ENSG00000023445
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 1.44
    Ensembl ID: ENSG00000156738
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.44
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.43
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104894
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.41
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.4
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.39
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.38
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 1.37
    Ensembl ID: ENSG00000105369
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.36
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.35
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.32
    Ensembl ID: ENSG00000110848
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CD1C (ENSG00000158481)
    Fold Change: 1.31
    Ensembl ID: ENSG00000158481
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.3
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104763
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.29
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.28
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.27
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.24
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.23
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.21
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.19
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.19
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.18
    Ensembl ID: ENSG00000197043
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.18
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.16
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.12
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.07
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087274
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196954
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198356
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177455
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.03
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.03
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 1.03
    Ensembl ID: ENSG00000007312
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.02
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1
    Ensembl ID: ENSG00000143119
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Surface Immunoglobulin Expression**: Mature B cells express IgM and IgD on their surface, which serves as the B cell receptor (BCR) and allows the cell to recognize antigens. 2. **Antigen Recognition**: Mature B cells can recognize antigens through their BCR, which is composed of immunoglobulin and associated proteins. 3. **Activation**: Mature B cells can be activated by antigen stimulation, leading to the activation of downstream signaling pathways and the production of antibodies. 4. **Antibody Production**: Activated mature B cells differentiate into plasma cells, which produce large amounts of antibodies in response to antigen stimulation. 5. **Cellular Differentiation**: Mature B cells undergo cellular differentiation into plasma cells, memory B cells, and follicular helper T cells (Tfh cells). **Clinical Significance** 1. **Immunodeficiency Diseases**: Defects in mature B cell development and function can lead to immunodeficiency diseases, such as X-linked agammaglobulinemia (XLA) and Bruton's agammaglobulinemia (BA). 2. **Autoimmune Diseases**: Abnormalities in mature B cell function can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: Mature B cells can undergo malignant transformation, leading to the development of B cell lymphomas, such as follicular lymphoma and diffuse large B cell lymphoma. 4. **Infectious Diseases**: Mature B cells play a crucial role in the production of antibodies against pathogens, such as Streptococcus pneumoniae and Haemophilus influenzae. 5. **Vaccine Development**: Mature B cells are an important target for vaccine development, as they can produce antibodies against specific antigens and provide long-term immunity. In summary, mature B cells are essential components of the adaptive immune response, and their dysfunction can lead to a range of clinical disorders. Understanding the biology of mature B cells is crucial for the development of effective treatments for various diseases.