Details for: CL0000787

Cell ID: CL0000787

Cell Name: memory B cell

Marker Score Threshold: 757
(Derived using integrated single-cell and genomic data)

Description: A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative.

Synonyms: memory B lymphocyte, memory B-cell, memory B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.81
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.62
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.48
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.36
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.35
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.22
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.15
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.97
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.94
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.93
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.88
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.86
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.86
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.62
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.59
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198931
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.46
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.37
    Ensembl ID: ENSG00000154518
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 2.31
    Ensembl ID: ENSG00000156738
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.27
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.25
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.22
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.21
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.14
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.13
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.11
    Ensembl ID: ENSG00000110955
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.01
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.98
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.97
    Ensembl ID: ENSG00000116459
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.86
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.86
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.84
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.8
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.79
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.78
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.76
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.76
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.71
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130303
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.69
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.68
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.67
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.62
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.61
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.59
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.58
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.56
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.56
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.56
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.56
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.54
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.52
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.51
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.46
    Ensembl ID: ENSG00000136573
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.46
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.44
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.42
    Ensembl ID: ENSG00000139193
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.4
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.39
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.39
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.38
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.38
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.34
    Ensembl ID: ENSG00000241837
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD22 (ENSG00000012124)
    Fold Change: 1.31
    Ensembl ID: ENSG00000012124
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.31
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.3
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.3
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.3
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164615
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.29
    Ensembl ID: ENSG00000177455
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.29
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.25
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.23
    Ensembl ID: ENSG00000148700
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177556
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.1
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.09
    Ensembl ID: ENSG00000074370
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.07
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.06
    Ensembl ID: ENSG00000089820
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.06
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.05
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.02
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1
    Ensembl ID: ENSG00000197894
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** Memory B cells are defined by their expression of specific surface markers, including CD19, CD20, MHC Class II, and CD138. They are also characterized by their ability to recognize and respond to specific antigens, and have been selected for their ability to express higher affinity immunoglobulins. * **Phenotype:** CD19-positive, CD20-positive, MHC Class II-positive, CD138-negative * **Function:** Recognize and respond to specific antigens, mount a rapid and effective immune response upon re-exposure to their antigenic determinant * **Antigen presentation:** Process and present antigens via MHC Class II molecules * **Immunoglobulin expression:** Express higher affinity immunoglobulins **Clinical Significance** Memory B cells play a critical role in the immune system, and their dysfunction has been implicated in various diseases, including autoimmune diseases and infections. * **Autoimmune diseases:** Memory B cells can contribute to autoimmune diseases by producing autoantibodies and presenting antigens to autoreactive T cells. * **Infections:** Memory B cells are essential for long-term immunity against pathogens, and their dysfunction can lead to recurrent infections. * **Cancer:** Memory B cells can contribute to cancer development by producing antibodies that target tumor antigens. * **Immunotherapy:** Memory B cells are being explored as a target for immunotherapy in various diseases, including cancer and autoimmune diseases. **Pathways/Ontology** Memory B cells are involved in various signaling pathways, including: * **Adaptive immune system:** Involved in the development and function of the adaptive immune system * **Antigen presentation:** Involved in the processing and presentation of antigens via MHC Class II molecules * **Cytokine signaling:** Involved in the regulation of immune responses by cytokines * **Cell-cell communication:** Involved in the regulation of immune responses by cell-cell interactions Overall, memory B cells are an essential component of the immune system, and their dysfunction has significant clinical implications. Further research is needed to understand the mechanisms of memory B cell function and to develop effective treatments for diseases related to memory B cell dysfunction.