Details for: CL0000792

Cell ID: CL0000792

Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell

Marker Score Threshold: 265
(Derived using integrated single-cell and genomic data)

Description: A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.

Synonyms: Treg, suppressor T cell, suppressor T lymphocyte, suppressor T-cell, suppressor T-lymphocyte, CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte, CD4-positive, CD25-positive, alpha-beta regulatory T-cell, CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.61
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.54
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.37
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.17
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.11
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.08
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.08
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.07
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.95
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.86
    Ensembl ID: ENSG00000169442
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.82
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.62
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.6
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.57
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.48
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 2.43
    Ensembl ID: ENSG00000139193
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.41
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.35
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.34
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.27
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.25
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.22
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.19
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.06
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.02
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.95
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.93
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.93
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.89
    Ensembl ID: ENSG00000077549
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.86
    Ensembl ID: ENSG00000160654
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.86
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.85
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.83
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.82
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.81
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.8
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.75
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.64
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.62
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.55
    Ensembl ID: ENSG00000168421
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.55
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.54
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.54
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.53
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.52
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.48
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.45
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.44
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.44
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.4
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.36
    Ensembl ID: ENSG00000112576
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.36
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.32
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.31
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.31
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.29
    Ensembl ID: ENSG00000023445
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110651
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.27
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.27
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.25
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.24
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.24
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.23
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.23
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.21
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.21
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.19
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.18
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.16
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.16
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.16
    Ensembl ID: ENSG00000110848
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.13
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.13
    Ensembl ID: ENSG00000153113
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.12
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.12
    Ensembl ID: ENSG00000013441
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.11
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.08
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137752
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.05
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.04
    Ensembl ID: ENSG00000136717
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.01
    Ensembl ID: ENSG00000221869
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.01
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.01
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174437
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD4 and CD25 Expression**: The cell expresses CD4, a co-receptor that helps T cells recognize antigens presented by MHC class II molecules, and CD25, also known as IL-2Rα, a receptor that binds to interleukin-2 (IL-2) and promotes T cell proliferation and differentiation. 2. **Alpha-beta T Cell Receptor (TCR)**: The cell expresses an alpha-beta TCR, which recognizes specific antigens presented by MHC class II molecules. 3. **Regulatory Function**: Tregs are characterized by their ability to suppress the activity of other immune cells, such as effector T cells, and promote tolerance to self-antigens. 4. **Cytokine Release**: Tregs release anti-inflammatory cytokines, such as transforming growth factor-beta (TGF-β) and IL-10, which inhibit the production of pro-inflammatory cytokines. 5. **Direct Cell-Cell Contact**: Tregs can also exert their regulatory effects through direct cell-cell contact, which involves the interaction of Treg cells with other immune cells. **Clinical Significance** 1. **Autoimmune Diseases**: Dysregulation of Tregs has been implicated in various autoimmune diseases, such as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. Restoring Treg function or increasing Treg numbers can help prevent or treat these diseases. 2. **Cancer Immunotherapy**: Tregs can also suppress the immune response against cancer cells, making them a target for cancer immunotherapy. 3. **Infectious Diseases**: Tregs can modulate the immune response to pathogens, reducing inflammation and tissue damage. 4. **Organ Transplantation**: Tregs can help prevent rejection of transplanted organs by suppressing the immune response against the graft. 5. **Immune System Disorders**: Tregs are also involved in immune system disorders, such as immunodeficiency and immune system dysfunction, where their function and numbers can be abnormal. In conclusion, the cell in question, CL0000792, is a CD4-positive, CD25-positive, alpha-beta regulatory T cell that plays a crucial role in regulating immune responses and preventing autoimmune diseases. Its unique characteristics and functions make it an important target for research into immune regulation and disease.