Details for: CL0000808

Cell ID: CL0000808

Cell Name: DN4 thymocyte

Marker Score Threshold: 352
(Derived using integrated single-cell and genomic data)

Description: A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.

Synonyms: early cortical thymocyte, DN4 alpha-beta immature T lymphocyte, DN4 alpha-beta immature T-lymphocyte, DN4 cell, DN4 immature T cell, DN4 immature T-cell, T.DN4.th, double negative 4

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.26
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.11
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.7
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.67
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.63
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.53
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.44
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.43
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.32
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.27
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.25
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.1
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.1
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.06
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.05
    Ensembl ID: ENSG00000143933
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.95
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.93
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.92
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.85
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.84
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.79
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.77
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.74
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.74
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.72
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.7
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.7
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.57
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.57
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.56
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.5
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.5
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.49
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.49
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.43
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.42
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.41
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.36
    Ensembl ID: ENSG00000182718
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.35
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.35
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.32
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.28
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.27
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.26
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.25
    Ensembl ID: ENSG00000173575
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.23
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.2
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.2
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.19
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.19
    Ensembl ID: ENSG00000110651
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.17
    Ensembl ID: ENSG00000026508
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.17
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.16
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.15
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.13
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.12
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.12
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.11
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.07
    Ensembl ID: ENSG00000141367
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.06
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.06
    Ensembl ID: ENSG00000074201
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.05
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.04
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.03
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.03
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.03
    Ensembl ID: ENSG00000175416
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134480
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.02
    Ensembl ID: ENSG00000122218
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087088
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1
    Ensembl ID: ENSG00000142599
Hovered Details

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Hovered Details

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**Key Characteristics** * CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive * Acts as a transitional phase between early and late stages of T cell development * Involves in various cellular processes, including cell signaling, adhesion, and cytoskeleton organization * Plays a critical role in the development of T cells and the regulation of immune responses * Has been implicated in various diseases, including autoimmune diseases and cancer **Clinical Significance** * DN4 thymocytes are essential for the development of functional T cells, which are critical for immune responses against pathogens and tumor cells. * Abnormalities in DN4 thymocyte development can lead to autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis. * DN4 thymocytes have also been implicated in cancer development, as they can contribute to the development of immunosuppressive tumors. * Understanding the function and regulation of DN4 thymocytes is crucial for the development of new therapeutic strategies for immune-related diseases. **Gene Expression and Pathways** * The DN4 thymocyte is characterized by the expression of various genes involved in cell signaling, adhesion, and cytoskeleton organization. * Key genes involved in DN4 thymocyte development include ACTB, which encodes for beta-actin, a crucial component of the cytoskeleton. * Other genes involved in DN4 thymocyte development include B2M, which encodes for beta-2 microglobulin, a component of MHC class I molecules. * The DN4 thymocyte is also involved in various signaling pathways, including MAPK and PI3K/AKT pathways, which play critical roles in cell survival and proliferation. **Diseases Associated with DN4 Thymocyte Abnormalities** * Autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis * Cancer, including immunosuppressive tumors * Infectious diseases, such as HIV and mycobacterial infections * Neurological disorders, such as Alzheimer's disease and Parkinson's disease In conclusion, the DN4 thymocyte is a crucial stage in T cell development and plays a critical role in the regulation of immune responses. Understanding the function and regulation of DN4 thymocytes is essential for the development of new therapeutic strategies for immune-related diseases.