Details for: CL0000809

Cell ID: CL0000809

Cell Name: double-positive, alpha-beta thymocyte

Marker Score Threshold: 1960
(Derived using integrated single-cell and genomic data)

Description: A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.

Synonyms: late cortical thymocyte, DP cell, DP thymocyte, double-positive, alpha-beta immature T lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD1E (ENSG00000158488)
    Fold Change: 18.81
    Ensembl ID: ENSG00000158488
  • Gene Symbol: CD1B (ENSG00000158485)
    Fold Change: 18.22
    Ensembl ID: ENSG00000158485
  • Gene Symbol: CD1A (ENSG00000158477)
    Fold Change: 10.63
    Ensembl ID: ENSG00000158477
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.25
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.15
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.14
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.09
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.05
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.03
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.03
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.02
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.02
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.95
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.88
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.74
    Ensembl ID: ENSG00000160654
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.53
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.52
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.52
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 2.45
    Ensembl ID: ENSG00000153563
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.45
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.44
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.37
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.35
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.34
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.31
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.29
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.28
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 2.27
    Ensembl ID: ENSG00000172116
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.27
    Ensembl ID: ENSG00000134825
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.2
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.19
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.18
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.14
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.12
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.12
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.1
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.08
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.04
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.97
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.96
    Ensembl ID: ENSG00000026508
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.94
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.91
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.91
    Ensembl ID: ENSG00000160014
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.86
    Ensembl ID: ENSG00000177105
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.85
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.84
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.83
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.82
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.78
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.78
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.77
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.76
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.76
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.72
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.67
    Ensembl ID: ENSG00000139193
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.63
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.62
    Ensembl ID: ENSG00000152495
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.61
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.61
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.59
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 1.59
    Ensembl ID: ENSG00000178538
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.56
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 1.55
    Ensembl ID: ENSG00000110448
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.52
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.5
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.49
    Ensembl ID: ENSG00000117410
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.49
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.46
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.46
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.44
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.43
    Ensembl ID: ENSG00000159199
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.37
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.36
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.3
    Ensembl ID: ENSG00000113328
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.23
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.22
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.21
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.18
    Ensembl ID: ENSG00000162772
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.17
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.17
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.16
    Ensembl ID: ENSG00000239900
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 1.16
    Ensembl ID: ENSG00000137752
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.14
    Ensembl ID: ENSG00000085662
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138696
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.12
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.11
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.11
    Ensembl ID: ENSG00000064012
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.05
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.04
    Ensembl ID: ENSG00000071553
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.02
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143149
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Alpha-Beta T Cell Receptor Complex**: The double-positive thymocyte expresses the alpha-beta T cell receptor complex, which is essential for the recognition of antigens. 2. **CD4 and CD8 Coreceptors**: This stage of T cell development is characterized by the expression of both CD4 and CD8 coreceptors. 3. **Transcriptional Profile**: The double-positive thymocyte has a unique transcriptional profile, which includes the expression of genes involved in T cell development, antigen processing, and presentation. 4. **Cellular Localization**: The double-positive thymocyte is typically found in the late cortical thymus, where it undergoes positive and negative selection. **Clinical Significance** 1. **Immunodeficiency**: Defects in T cell development and selection can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune Diseases**: Abnormalities in T cell development and selection can also contribute to autoimmune diseases, such as type 1 diabetes and multiple sclerosis. 3. **Cancer**: T cell dysfunction and abnormalities in T cell development and selection have been implicated in various types of cancer, including leukemia and lymphoma. 4. **Vaccine Development**: Understanding the mechanisms of T cell development and selection is crucial for the development of effective vaccines and immunotherapies. **Pathways and Ontology** 1. **Adaptive Immune Response**: The double-positive thymocyte plays a critical role in the adaptive immune response, which involves the activation of T cells in response to antigen presentation. 2. **Antigen Processing and Presentation**: The double-positive thymocyte is involved in the processing and presentation of antigens to T cells, which is essential for the activation of T cells. 3. **Endogenous Lipid Antigen via MHC Class IIb**: The double-positive thymocyte expresses MHC class IIb, which is involved in the presentation of endogenous lipid antigens to T cells. 4. **Exogenous Lipid Antigen via MHC Class IIb**: The double-positive thymocyte also expresses MHC class IIb, which is involved in the presentation of exogenous lipid antigens to T cells. In summary, the double-positive, alpha-beta thymocyte is a critical stage of T cell development, characterized by the expression of the alpha-beta T cell receptor complex and both CD4 and CD8 coreceptors. This stage is essential for the selection and maturation of T cells, which will eventually become functional T cells that play a key role in the adaptive immune response.