Details for: CL0000811

Cell ID: CL0000811

Cell Name: CD8-positive, alpha-beta thymocyte

Marker Score Threshold: 552
(Derived using integrated single-cell and genomic data)

Description: An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative.

Synonyms: CD8-positive, alpha-beta immature T lymphocyte, CD8-positive, alpha-beta immature T-cell, CD8-positive, alpha-beta immature T-lymphocyte, SP CD8 cell, CD8-positive, alpha-beta immature T cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.98
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.68
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.65
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 3.59
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.56
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.52
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.45
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.4
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.38
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.27
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.27
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.26
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.21
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.19
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.19
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.07
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.96
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.93
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.93
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.9
    Ensembl ID: ENSG00000099622
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.84
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.73
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.72
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.71
    Ensembl ID: ENSG00000149925
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.56
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.56
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.54
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.5
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.5
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.43
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.38
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.37
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 2.36
    Ensembl ID: ENSG00000153563
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.36
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.32
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.3
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.3
    Ensembl ID: ENSG00000213719
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.3
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.25
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.15
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.15
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.14
    Ensembl ID: ENSG00000112576
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.14
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.13
    Ensembl ID: ENSG00000152234
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.12
    Ensembl ID: ENSG00000135940
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.05
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.03
    Ensembl ID: ENSG00000160654
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.99
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 1.97
    Ensembl ID: ENSG00000172116
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.96
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.95
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.93
    Ensembl ID: ENSG00000182718
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.93
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.85
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.82
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.77
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.7
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.65
    Ensembl ID: ENSG00000085224
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.61
    Ensembl ID: ENSG00000057657
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.58
    Ensembl ID: ENSG00000020633
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.58
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.56
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.54
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.54
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.49
    Ensembl ID: ENSG00000109861
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.48
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.43
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.42
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.42
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.39
    Ensembl ID: ENSG00000172216
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.35
    Ensembl ID: ENSG00000087088
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.35
    Ensembl ID: ENSG00000105254
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.35
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.35
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.34
    Ensembl ID: ENSG00000153113
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.28
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.26
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.25
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.17
    Ensembl ID: ENSG00000136717
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.16
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.14
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.12
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.12
    Ensembl ID: ENSG00000064012
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.09
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.06
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163399
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198356
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.03
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.01
    Ensembl ID: ENSG00000185650
  • Gene Symbol: COMT (ENSG00000093010)
    Fold Change: 1
    Ensembl ID: ENSG00000093010
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD8-positive and CD4-negative**: This cell is a subset of T cells that express CD8 but lack CD4, indicating its role in cytotoxic T cell function. 2. **Alpha-beta thymocyte**: This cell is an immature T cell that is still undergoing development in the thymus. 3. **Immunological functions**: The cell is involved in antigen presentation, cytokine signaling, and immune response regulation. 4. **Gene expression**: The cell's genes are involved in various immunological processes, including antigen presentation and cytokine signaling. 5. **Pathways and ontology**: The cell's pathways and ontology include adaptive immune system, amyloid fiber formation, and various immune-related processes. **Clinical Significance** 1. **Immune system disorders**: Abnormalities in CD8-positive, alpha-beta thymocyte function can lead to immune system disorders, such as autoimmune diseases or impaired immune responses. 2. **Cancer**: Dysregulation of CD8-positive, alpha-beta thymocyte function can contribute to the development of certain types of cancer, such as leukemia or lymphoma. 3. **Infectious diseases**: The cell's involvement in antigen presentation and cytokine signaling makes it a critical component of the immune response to infectious diseases. 4. **Transplantation and immunotherapy**: The cell's function can be affected by immunosuppressive or immunomodulatory therapies used in transplantation and immunotherapy. 5. **Neurological disorders**: Abnormalities in CD8-positive, alpha-beta thymocyte function have been linked to certain neurological disorders, such as multiple sclerosis or Alzheimer's disease. In conclusion, the CD8-positive, alpha-beta thymocyte is a critical component of the adaptive immune system, and its dysfunction can lead to various immunological disorders. Understanding the cell's characteristics, functions, and interactions with other molecules and organelles is essential for the development of effective treatments for immune-related diseases.