Details for: CL0000818

Cell ID: CL0000818

Cell Name: transitional stage B cell

Marker Score Threshold: 354
(Derived using integrated single-cell and genomic data)

Description: An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.

Synonyms: transitional B cell, transitional stage B lymphocyte, transitional stage B-cell, transitional stage B-lymphocyte, T1 B cell, T2 B cell, T3 B cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.1
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.1
    Ensembl ID: ENSG00000166710
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 3.08
    Ensembl ID: ENSG00000156738
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.05
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.04
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.98
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.95
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.83
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.82
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.69
    Ensembl ID: ENSG00000184009
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.65
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.57
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.48
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.46
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.4
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.39
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.28
    Ensembl ID: ENSG00000165527
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.24
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.22
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.2
    Ensembl ID: ENSG00000179218
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 2.16
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.06
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.05
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 2.03
    Ensembl ID: ENSG00000136573
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.99
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.95
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.95
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.95
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.95
    Ensembl ID: ENSG00000128271
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.94
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.89
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.89
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.88
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.85
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.84
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD22 (ENSG00000012124)
    Fold Change: 1.81
    Ensembl ID: ENSG00000012124
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.78
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.76
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.75
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.72
    Ensembl ID: ENSG00000148700
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.68
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.67
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.67
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.64
    Ensembl ID: ENSG00000122359
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.57
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.53
    Ensembl ID: ENSG00000171791
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.52
    Ensembl ID: ENSG00000100823
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.51
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.5
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.49
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.48
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.47
    Ensembl ID: ENSG00000087274
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.46
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.44
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.42
    Ensembl ID: ENSG00000074370
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.42
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.4
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.4
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.4
    Ensembl ID: ENSG00000177455
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.38
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.37
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.37
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.35
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.32
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.32
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.31
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.29
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.29
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.28
    Ensembl ID: ENSG00000112576
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.26
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: 1.25
    Ensembl ID: ENSG00000243989
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.24
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.24
    Ensembl ID: ENSG00000089820
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.18
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.17
    Ensembl ID: ENSG00000182718
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.16
    Ensembl ID: ENSG00000107262
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.15
    Ensembl ID: ENSG00000020633
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.15
    Ensembl ID: ENSG00000010671
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.12
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.11
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.11
    Ensembl ID: ENSG00000114423
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.09
    Ensembl ID: ENSG00000102575
  • Gene Symbol: CD1C (ENSG00000158481)
    Fold Change: 1.08
    Ensembl ID: ENSG00000158481
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.06
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.05
    Ensembl ID: ENSG00000145349
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.04
    Ensembl ID: ENSG00000105221
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.01
    Ensembl ID: ENSG00000127022
Hovered Details

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Hovered Details

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**Key Characteristics** * Transitional stage B cells are a subset of immature B cells that are in an intermediate stage of development between the pre-B cell stage and the mature naive stage. * They express surface IgM and CD19, and are subject to the process of B cell selection. * Transitional B cells migrate from the bone marrow into the peripheral circulation and then to the spleen, where they undergo further maturation and selection. * They have a unique surface phenotype that is distinct from both pre-B and mature B cells. * Transitional B cells are characterized by the expression of specific genes, including ACTB and B2M, which are involved in various cellular processes, including cell adhesion, signaling, and protein synthesis. **Clinical Significance** * Transitional B cells play a critical role in the development and function of the adaptive immune system, particularly in the context of B cell selection and maturation. * Abnormalities in transitional B cell development and function have been implicated in various immune-related disorders, including autoimmune diseases, immunodeficiency disorders, and cancer. * Understanding the biology and function of transitional B cells is important for the development of novel therapeutic strategies for these disorders. * Transitional B cells have also been implicated in the pathogenesis of certain infectious diseases, such as Leishmania infection, and the development of cancer. **Gene Expression and Regulation** * Transitional B cells express a unique set of genes that are involved in various cellular processes, including cell adhesion, signaling, and protein synthesis. * The expression of these genes is regulated by a complex interplay of transcriptional and post-transcriptional mechanisms, including the activity of transcription factors, chromatin remodeling complexes, and microRNAs. * The regulation of gene expression in transitional B cells is critical for the proper development and function of these cells, and dysregulation of gene expression has been implicated in various immune-related disorders. **Pathways and Ontologies** * Transitional B cells are involved in various cellular processes, including cell adhesion, signaling, and protein synthesis, which are regulated by a complex interplay of signaling pathways and molecular interactions. * The expression of specific genes, including ACTB and B2M, is regulated by a variety of molecular mechanisms, including transcriptional and post-transcriptional regulation, chromatin remodeling, and epigenetic modification. * Transitional B cells are also involved in various immune-related processes, including antigen presentation, cytokine signaling, and immune cell interactions, which are regulated by a complex interplay of molecular interactions and signaling pathways. **References** * [Insert references to relevant scientific articles and studies on transitional B cells]