Details for: CL0000821

Cell ID: CL0000821

Cell Name: B-1b B cell

Marker Score Threshold: 230
(Derived using integrated single-cell and genomic data)

Description: A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell.

Synonyms: B-1b B lymphocyte, B-1b B-cell, B-1b B-lymphocyte, B1b B cell, B1b B lymphocyte, B1b B-cell, B1b B-lymphocyte, B1b cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.72
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.48
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.35
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.35
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.32
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.31
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.28
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.27
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.26
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.22
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.14
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.12
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.08
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143933
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.94
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.9
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.88
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.87
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.84
    Ensembl ID: ENSG00000197043
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.79
    Ensembl ID: ENSG00000185883
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.78
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.78
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.75
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.75
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.72
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.72
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.7
    Ensembl ID: ENSG00000136573
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.68
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.67
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.67
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.66
    Ensembl ID: ENSG00000012779
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.65
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.64
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.63
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.6
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.57
    Ensembl ID: ENSG00000179218
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.56
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.55
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.55
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.55
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.52
    Ensembl ID: ENSG00000117410
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.51
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.49
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.49
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.49
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.46
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.46
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.44
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.43
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.42
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.42
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.41
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.41
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.4
    Ensembl ID: ENSG00000089820
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.37
    Ensembl ID: ENSG00000162909
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.36
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.33
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.32
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.31
    Ensembl ID: ENSG00000153113
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.27
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.25
    Ensembl ID: ENSG00000074370
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.23
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.22
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.22
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.22
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.19
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.17
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.16
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.15
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.12
    Ensembl ID: ENSG00000145349
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.12
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.11
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.1
    Ensembl ID: ENSG00000168374
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.09
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.07
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.06
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.06
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.05
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.05
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.02
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.02
    Ensembl ID: ENSG00000198363
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1
    Ensembl ID: ENSG00000100852
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD5-negative phenotype**: B-1b B cells lack the CD5 molecule, which is a characteristic shared with B-1a B cells. 2. **IgM and IgD antibody production**: B-1b B cells are capable of producing IgM and IgD antibodies, which are involved in the humoral immune response. 3. **Participation in innate immunity**: B-1b B cells contribute to the innate immune response by producing cytokines and activating other immune cells, such as neutrophils and macrophages. 4. **Elimination of encapsulated bacteria**: B-1b B cells play a crucial role in the defense against encapsulated bacteria, such as Streptococcus pneumoniae and Haemophilus influenzae. 5. **Defense against Leishmania parasites**: B-1b B cells are involved in the defense against Leishmania parasites, which are transmitted by sandflies. 6. **Expression of CD8a, CD19, and CD20**: B-1b B cells express the CD8a, CD19, and CD20 surface molecules, which are involved in B-cell development and function. 7. **BCR signaling pathway regulation**: B-1b B cells are regulated by the B-cell receptor (BCR) signaling pathway, which is involved in B-cell activation and differentiation. **Clinical Significance** 1. **Autoimmune diseases**: B-1b B cells have been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, due to their ability to produce autoantibodies. 2. **Infections**: B-1b B cells play a crucial role in the defense against infections, such as Streptococcus pneumoniae and Haemophilus influenzae, and are involved in the elimination of Leishmania parasites. 3. **Cancer**: B-1b B cells have been implicated in the development and progression of certain types of cancer, such as multiple myeloma and lymphoma. 4. **Immunotherapy**: B-1b B cells have been explored as a target for immunotherapy, due to their ability to produce cytokines and activate other immune cells. 5. **Vaccine development**: B-1b B cells have been studied as a potential target for vaccine development, due to their ability to produce antibodies and contribute to the innate immune response. In conclusion, the B-1b B cell is a unique subtype of B lymphocytes that plays a crucial role in the humoral and innate immune responses, and has been implicated in various diseases, including autoimmune diseases, infections, and cancer. Further research is needed to fully understand the functions and dysregulations of B-1b B cells in human health and disease.