Details for: CL0000822

Cell ID: CL0000822

Cell Name: B-2 B cell

Marker Score Threshold: 1230
(Derived using integrated single-cell and genomic data)

Description: A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative.

Synonyms: B-2 B lymphocyte, B-2 B-cell, B-2 B-lymphocyte, B2 B cell, B2 B lymphocyte, B2 B-cell, B2 B-lymphocyte, B2 cell, B-0 B cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 3.82
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.23
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.13
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.86
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.83
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.82
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.69
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.63
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.52
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.42
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.34
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.27
    Ensembl ID: ENSG00000070831
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.26
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.18
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.14
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.13
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.12
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.11
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.1
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.09
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.09
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.05
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.02
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.01
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.87
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.85
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.83
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.81
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.79
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.78
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.74
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.74
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.73
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.7
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.69
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.64
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 1.62
    Ensembl ID: ENSG00000109107
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.61
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.61
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.61
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.61
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.55
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.55
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.55
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.55
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.54
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.54
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.53
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104964
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.5
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.5
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.47
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.46
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.41
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.4
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.39
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.38
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.37
    Ensembl ID: ENSG00000110651
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.35
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.32
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.32
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.31
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.3
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.3
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.3
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.28
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.28
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.24
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BYSL (ENSG00000112578)
    Fold Change: 1.21
    Ensembl ID: ENSG00000112578
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.16
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CETN3 (ENSG00000153140)
    Fold Change: 1.15
    Ensembl ID: ENSG00000153140
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.14
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.14
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.12
    Ensembl ID: ENSG00000112576
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.08
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.08
    Ensembl ID: ENSG00000128271
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.07
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131100
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.04
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.03
    Ensembl ID: ENSG00000175906
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.03
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.02
    Ensembl ID: ENSG00000169442
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.01
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1
    Ensembl ID: ENSG00000196954
Hovered Details

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Hovered Details

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**Key Characteristics** * B-2 B cells are a subtype of B lymphocyte that requires T cell help to activate their immune response. * They are characterized by their ability to recognize and respond to specific antigens. * B-2 B cells have a distinct surface marker expression pattern that distinguishes them from B-1 B cells. * They are negative for the CD43 marker. * B-2 B cells are involved in various pathological processes, including autoimmune diseases and cancer. **Clinical Significance** * B-2 B cells play a crucial role in the adaptive immune system, and their dysregulation can lead to autoimmune diseases and cancer. * B-2 B cells are involved in the production of autoantibodies, which can contribute to the pathogenesis of autoimmune diseases such as rheumatoid arthritis and lupus. * B-2 B cells can also contribute to the development of cancer by producing anti-tumor antibodies that inhibit the immune response against tumor cells. * Understanding the function and regulation of B-2 B cells is essential for the development of novel therapeutic strategies for autoimmune diseases and cancer. **Genetic Background** * The gene symbol for the B-2 B cell is SERPINH1. * The gene symbol for the B-2 B cell is ACTB. * The gene symbol for the B-2 B cell is B2M. **Pathways and Ontologies** * B-2 B cells are involved in various cellular responses, including attenuation phase, cellular responses to stimuli, cellular responses to stress, and cellular response to heat stress. * B-2 B cells are also involved in the regulation of collagen biosynthesis and modifying enzymes, collagen fibril organization, and collagen formation. * B-2 B cells are involved in the regulation of endoplasmic reticulum, endoplasmic reticulum-golgi intermediate compartment, and endoplasmic reticulum lumen. * B-2 B cells are also involved in the regulation of extracellular matrix organization, extracellular space, and Hsf1 activation. **Biological Processes** * B-2 B cells are involved in the regulation of actin cytoskeleton, actin filament, adherens junction, adherens junction assembly, and adherens junctions interactions. * B-2 B cells are also involved in the regulation of apical junction complex, apical protein localization, Atp binding, axon, axon guidance, axonogenesis, and B-wich complex positively regulates rrna expression. * B-2 B cells are involved in the regulation of blood microparticle, brahma complex, brush border, calyx of held, cell-cell communication, cell-cell junction, cell-cell junction organization, cell-extracellular matrix interactions, and cell junction organization. **Diseases** * B-2 B cells are involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis and lupus. * B-2 B cells can also contribute to the development of cancer by producing anti-tumor antibodies that inhibit the immune response against tumor cells. * Understanding the function and regulation of B-2 B cells is essential for the development of novel therapeutic strategies for autoimmune diseases and cancer.