Details for: CL0000823

Cell ID: CL0000823

Cell Name: immature natural killer cell

Marker Score Threshold: 433
(Derived using integrated single-cell and genomic data)

Description: A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR).

Synonyms: immature NK cell, p-NK

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.64
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.52
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.51
    Ensembl ID: ENSG00000156508
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.23
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.17
    Ensembl ID: ENSG00000131143
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.14
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.13
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.1
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.09
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.05
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.97
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.88
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.85
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.84
    Ensembl ID: ENSG00000156976
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.84
    Ensembl ID: ENSG00000124172
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.84
    Ensembl ID: ENSG00000114942
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.83
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.75
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.7
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.7
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.7
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.68
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.65
    Ensembl ID: ENSG00000135404
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.61
    Ensembl ID: ENSG00000067082
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.6
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.6
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.6
    Ensembl ID: ENSG00000077549
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.58
    Ensembl ID: ENSG00000110321
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.55
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.54
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.54
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.52
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.46
    Ensembl ID: ENSG00000154723
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.46
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.45
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.42
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.42
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.41
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.41
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.4
    Ensembl ID: ENSG00000213719
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.4
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.4
    Ensembl ID: ENSG00000134825
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100664
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.38
    Ensembl ID: ENSG00000051523
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.37
    Ensembl ID: ENSG00000131174
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.36
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.34
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.34
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.33
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.31
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.29
    Ensembl ID: ENSG00000153113
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.29
    Ensembl ID: ENSG00000215301
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.28
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.27
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.26
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.26
    Ensembl ID: ENSG00000117410
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.25
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.25
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198931
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.2
    Ensembl ID: ENSG00000173674
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.18
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.17
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.16
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.16
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.16
    Ensembl ID: ENSG00000013441
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.16
    Ensembl ID: ENSG00000132507
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.14
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.13
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168374
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.1
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.08
    Ensembl ID: ENSG00000117984
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.07
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.06
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.06
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.06
    Ensembl ID: ENSG00000168036
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104765
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128951
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.03
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.02
    Ensembl ID: ENSG00000072778
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.02
    Ensembl ID: ENSG00000130741
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.01
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.01
    Ensembl ID: ENSG00000159199
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 1
    Ensembl ID: ENSG00000161960
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: N/A
    Ensembl ID: ENSG00000197102
Hovered Details

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Hovered Details

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**Key Characteristics** * Immature natural killer cell (iNK cell) * Expresses natural killer cell receptors (NKR) * Developmentally immature * Involved in the innate immune system * Recognizes and kills infected cells or tumor cells without prior antigen exposure * Has a unique set of genes involved in various cellular processes, including: + Cell signaling + Apoptosis + Protein trafficking + Actin cytoskeleton organization + Adherens junction assembly and disassembly + Endocytosis and exocytosis + Protein folding and modification + Gene expression and regulation **Clinical Significance** iNK cells play a crucial role in the innate immune system and have been implicated in various diseases, including: * Cancer: iNK cells can recognize and kill tumor cells, making them a target for cancer immunotherapy. * Autoimmune diseases: iNK cells can contribute to autoimmune diseases by recognizing and attacking self-antigens. * Infections: iNK cells can recognize and kill infected cells, making them a key component of the innate immune response. * Neurological disorders: iNK cells have been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. Understanding the function and regulation of iNK cells is essential for developing effective treatments for these diseases. Research on iNK cells has also led to the development of new therapeutic strategies, including immunotherapies and gene therapies. **Gene Expression and Regulation** iNK cells have a unique gene expression profile that is distinct from other immune cells. They express a range of genes involved in cell signaling, apoptosis, and protein trafficking, as well as genes involved in the regulation of gene expression. The iNK cell's gene expression profile is influenced by various transcription factors, including: * T-bet: a transcription factor that regulates the expression of genes involved in cell signaling and apoptosis. * IRF4: a transcription factor that regulates the expression of genes involved in the regulation of gene expression. * STAT1: a transcription factor that regulates the expression of genes involved in cell signaling and apoptosis. Understanding the regulation of gene expression in iNK cells is essential for developing effective treatments for diseases. **Cell Signaling and Pathways** iNK cells use a range of signaling pathways to regulate their function, including: * MAPK signaling pathway: a signaling pathway that regulates cell signaling and apoptosis. * PI3K/AKT signaling pathway: a signaling pathway that regulates cell signaling and protein trafficking. * JAK/STAT signaling pathway: a signaling pathway that regulates gene expression and cell signaling. Understanding the signaling pathways involved in iNK cell function is essential for developing effective treatments for diseases. **Protein Trafficking and Folding** iNK cells use a range of proteins to regulate their function, including: * Actin cytoskeleton proteins: proteins involved in the regulation of cell motility and cell signaling. * Adherens junction proteins: proteins involved in the regulation of cell-cell adhesion and signaling. * Endocytosis proteins: proteins involved in the regulation of protein trafficking and cell signaling. Understanding the regulation of protein trafficking and folding in iNK cells is essential for developing effective treatments for diseases. **In conclusion** iNK cells are a unique type of immune cell that plays a crucial role in the innate immune system. They have a distinct set of genes and signaling pathways that regulate their function, and are involved in various diseases, including cancer, autoimmune diseases, and neurological disorders. Understanding the regulation of iNK cell function is essential for developing effective treatments for these diseases.