Details for: CL0000826

Cell ID: CL0000826

Cell Name: pro-B cell

Marker Score Threshold: 965
(Derived using integrated single-cell and genomic data)

Description: A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.

Synonyms: pre-pro B cell, pro-B lymphocyte, pro-B-cell, pro-B-lymphocyte, progenitor B cell, progenitor B lymphocyte, progenitor B-cell, progenitor B-lymphocyte, pre-B cell (Philadelphia nomenclature)

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.12
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.97
    Ensembl ID: ENSG00000099622
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.88
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.87
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.77
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.61
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.53
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.42
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.38
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.37
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.37
    Ensembl ID: ENSG00000110955
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.36
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.33
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.3
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.24
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.2
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.19
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.19
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.17
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.08
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.08
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.08
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.07
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.05
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.02
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.95
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.94
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.93
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.93
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.86
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.83
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.81
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.77
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.73
    Ensembl ID: ENSG00000153922
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.72
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.7
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.68
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.67
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.65
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.63
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.62
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.62
    Ensembl ID: ENSG00000143727
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.61
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.58
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.58
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.55
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.55
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.51
    Ensembl ID: ENSG00000149925
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.49
    Ensembl ID: ENSG00000108561
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.49
    Ensembl ID: ENSG00000053254
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.48
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.44
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.43
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.42
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.41
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.38
    Ensembl ID: ENSG00000197894
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.37
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.35
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.33
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.32
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.29
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.28
    Ensembl ID: ENSG00000145241
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.28
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.22
    Ensembl ID: ENSG00000111276
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.21
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.2
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.2
    Ensembl ID: ENSG00000111642
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.18
    Ensembl ID: ENSG00000140299
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.18
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.16
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.15
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.14
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.14
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.12
    Ensembl ID: ENSG00000107262
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.11
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.09
    Ensembl ID: ENSG00000096401
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.08
    Ensembl ID: ENSG00000134480
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.07
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.07
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.06
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164111
Hovered Details

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Hovered Details

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**Key Characteristics** * Pro-B cells are a stage in the development of B cells, characterized by early stages of B cell receptor gene recombination. * They express specific genes, including BTF3, ATP5MC2, CIRBP, SLC25A6, CFL1, BTG1, and RHOA, which are involved in cellular processes such as energy metabolism, stress response, cell migration, and signaling pathways. * Pro-B cells have not yet fully committed to the B cell lineage and require the expression of PAX5 to fully differentiate into mature B cells. * They are involved in the development and function of the immune system, particularly in the B cell lineage. **Clinical Significance** * Pro-B cells are an important stage in the development of B cells, which are a crucial component of the adaptive immune system. * Abnormalities in pro-B cell development and function can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). * Understanding the regulation of pro-B cell development and function is essential for the development of novel therapeutic strategies for immunodeficiency disorders. * The genes expressed by pro-B cells, such as BTF3 and RHOA, are also involved in other cellular processes, making them potential targets for cancer therapy. * The study of pro-B cell development and function can provide insights into the mechanisms of immune system development and function, and may lead to the development of novel immunotherapies. **Pathways and Ontologies** * The genes expressed by pro-B cells are involved in various cellular processes, including: + Energy metabolism: ATP5MC2, SLC25A6 + Stress response: CIRBP, BTG1 + Cell migration: CFL1, RHOA + Signaling pathways: BTF3, RHOA * The cell is involved in the development and function of the immune system, particularly in the B cell lineage. * The pathways and ontologies involved in pro-B cell development and function include: + In utero embryonic development + Nascent polypeptide-associated complex + Negative regulation of protein localization to endoplasmic reticulum + Nucleus + Protein binding + Protein transport + Rna binding **References** * [Insert references to relevant scientific literature] Note: The above summary, key characteristics, clinical significance, pathways and ontologies, and references sections are hypothetical and based on the provided information. The actual content may vary depending on the specific cell type and the context of the article.