Details for: CL0000834

Cell ID: CL0000834

Cell Name: neutrophil progenitor cell

Marker Score Threshold: 256
(Derived using integrated single-cell and genomic data)

Description: A progenitor cell of the neutrophil lineage.

Synonyms: neutrophil stem cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: RPL13 (ENSG00000167526)
    Fold Change: 3.99
    Ensembl ID: ENSG00000167526
  • Gene Symbol: RPLP1 (ENSG00000137818)
    Fold Change: 3.99
    Ensembl ID: ENSG00000137818
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: RPL11 (ENSG00000142676)
    Fold Change: 3.79
    Ensembl ID: ENSG00000142676
  • Gene Symbol: RPS8 (ENSG00000142937)
    Fold Change: 3.78
    Ensembl ID: ENSG00000142937
  • Gene Symbol: RPL34 (ENSG00000109475)
    Fold Change: 3.74
    Ensembl ID: ENSG00000109475
  • Gene Symbol: TPT1 (ENSG00000133112)
    Fold Change: 3.73
    Ensembl ID: ENSG00000133112
  • Gene Symbol: RPS6 (ENSG00000137154)
    Fold Change: 3.7
    Ensembl ID: ENSG00000137154
  • Gene Symbol: RPL30 (ENSG00000156482)
    Fold Change: 3.69
    Ensembl ID: ENSG00000156482
  • Gene Symbol: RPS27A (ENSG00000143947)
    Fold Change: 3.69
    Ensembl ID: ENSG00000143947
  • Gene Symbol: RPL32 (ENSG00000144713)
    Fold Change: 3.69
    Ensembl ID: ENSG00000144713
  • Gene Symbol: RPS3 (ENSG00000149273)
    Fold Change: 3.69
    Ensembl ID: ENSG00000149273
  • Gene Symbol: RPS24 (ENSG00000138326)
    Fold Change: 3.68
    Ensembl ID: ENSG00000138326
  • Gene Symbol: RPL37A (ENSG00000197756)
    Fold Change: 3.68
    Ensembl ID: ENSG00000197756
  • Gene Symbol: RPL19 (ENSG00000108298)
    Fold Change: 3.67
    Ensembl ID: ENSG00000108298
  • Gene Symbol: RPL28 (ENSG00000108107)
    Fold Change: 3.67
    Ensembl ID: ENSG00000108107
  • Gene Symbol: RPL8 (ENSG00000161016)
    Fold Change: 3.67
    Ensembl ID: ENSG00000161016
  • Gene Symbol: RPS12 (ENSG00000112306)
    Fold Change: 3.67
    Ensembl ID: ENSG00000112306
  • Gene Symbol: RPL18 (ENSG00000063177)
    Fold Change: 3.66
    Ensembl ID: ENSG00000063177
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.66
    Ensembl ID: ENSG00000156508
  • Gene Symbol: RPLP2 (ENSG00000177600)
    Fold Change: 3.66
    Ensembl ID: ENSG00000177600
  • Gene Symbol: RPS14 (ENSG00000164587)
    Fold Change: 3.65
    Ensembl ID: ENSG00000164587
  • Gene Symbol: RPS27 (ENSG00000177954)
    Fold Change: 3.65
    Ensembl ID: ENSG00000177954
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.63
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.63
    Ensembl ID: ENSG00000087086
  • Gene Symbol: PTMA (ENSG00000187514)
    Fold Change: 3.62
    Ensembl ID: ENSG00000187514
  • Gene Symbol: RPS15 (ENSG00000115268)
    Fold Change: 3.61
    Ensembl ID: ENSG00000115268
  • Gene Symbol: RPL3 (ENSG00000100316)
    Fold Change: 3.61
    Ensembl ID: ENSG00000100316
  • Gene Symbol: RPL35A (ENSG00000182899)
    Fold Change: 3.61
    Ensembl ID: ENSG00000182899
  • Gene Symbol: RPS2 (ENSG00000140988)
    Fold Change: 3.6
    Ensembl ID: ENSG00000140988
  • Gene Symbol: RPS28 (ENSG00000233927)
    Fold Change: 3.59
    Ensembl ID: ENSG00000233927
  • Gene Symbol: RPS23 (ENSG00000186468)
    Fold Change: 3.59
    Ensembl ID: ENSG00000186468
  • Gene Symbol: RPS4X (ENSG00000198034)
    Fold Change: 3.59
    Ensembl ID: ENSG00000198034
  • Gene Symbol: RPL37 (ENSG00000145592)
    Fold Change: 3.58
    Ensembl ID: ENSG00000145592
  • Gene Symbol: RPL41 (ENSG00000229117)
    Fold Change: 3.58
    Ensembl ID: ENSG00000229117
  • Gene Symbol: RPL5 (ENSG00000122406)
    Fold Change: 3.56
    Ensembl ID: ENSG00000122406
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.56
    Ensembl ID: ENSG00000132475
  • Gene Symbol: RPL27A (ENSG00000166441)
    Fold Change: 3.55
    Ensembl ID: ENSG00000166441
  • Gene Symbol: RPS29 (ENSG00000213741)
    Fold Change: 3.55
    Ensembl ID: ENSG00000213741
  • Gene Symbol: RPL15 (ENSG00000174748)
    Fold Change: 3.54
    Ensembl ID: ENSG00000174748
  • Gene Symbol: RPS11 (ENSG00000142534)
    Fold Change: 3.53
    Ensembl ID: ENSG00000142534
  • Gene Symbol: RPL21 (ENSG00000122026)
    Fold Change: 3.5
    Ensembl ID: ENSG00000122026
  • Gene Symbol: TMSB4X (ENSG00000205542)
    Fold Change: 3.5
    Ensembl ID: ENSG00000205542
  • Gene Symbol: RPL10 (ENSG00000147403)
    Fold Change: 3.49
    Ensembl ID: ENSG00000147403
  • Gene Symbol: RPS16 (ENSG00000105193)
    Fold Change: 3.49
    Ensembl ID: ENSG00000105193
  • Gene Symbol: RPL12 (ENSG00000197958)
    Fold Change: 3.48
    Ensembl ID: ENSG00000197958
  • Gene Symbol: RPS19 (ENSG00000105372)
    Fold Change: 3.47
    Ensembl ID: ENSG00000105372
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.47
    Ensembl ID: ENSG00000149806
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 3.46
    Ensembl ID: ENSG00000198804
  • Gene Symbol: RPLP0 (ENSG00000089157)
    Fold Change: 3.43
    Ensembl ID: ENSG00000089157
  • Gene Symbol: RPL31 (ENSG00000071082)
    Fold Change: 3.42
    Ensembl ID: ENSG00000071082
  • Gene Symbol: RPS3A (ENSG00000145425)
    Fold Change: 3.42
    Ensembl ID: ENSG00000145425
  • Gene Symbol: TMSB10 (ENSG00000034510)
    Fold Change: 3.41
    Ensembl ID: ENSG00000034510
  • Gene Symbol: RPL23A (ENSG00000198242)
    Fold Change: 3.41
    Ensembl ID: ENSG00000198242
  • Gene Symbol: RPS15A (ENSG00000134419)
    Fold Change: 3.41
    Ensembl ID: ENSG00000134419
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.4
    Ensembl ID: ENSG00000111640
  • Gene Symbol: RPS21 (ENSG00000171858)
    Fold Change: 3.38
    Ensembl ID: ENSG00000171858
  • Gene Symbol: RPS13 (ENSG00000110700)
    Fold Change: 3.38
    Ensembl ID: ENSG00000110700
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 3.36
    Ensembl ID: ENSG00000198938
  • Gene Symbol: RPL6 (ENSG00000089009)
    Fold Change: 3.36
    Ensembl ID: ENSG00000089009
  • Gene Symbol: RPL9 (ENSG00000163682)
    Fold Change: 3.36
    Ensembl ID: ENSG00000163682
  • Gene Symbol: RPS5 (ENSG00000083845)
    Fold Change: 3.36
    Ensembl ID: ENSG00000083845
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 3.36
    Ensembl ID: ENSG00000198712
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.35
    Ensembl ID: ENSG00000122566
  • Gene Symbol: UBC (ENSG00000150991)
    Fold Change: 3.35
    Ensembl ID: ENSG00000150991
  • Gene Symbol: RPL38 (ENSG00000172809)
    Fold Change: 3.34
    Ensembl ID: ENSG00000172809
  • Gene Symbol: RPL14 (ENSG00000188846)
    Fold Change: 3.34
    Ensembl ID: ENSG00000188846
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 3.32
    Ensembl ID: ENSG00000198755
  • Gene Symbol: RPS18 (ENSG00000231500)
    Fold Change: 3.32
    Ensembl ID: ENSG00000231500
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 3.31
    Ensembl ID: ENSG00000092841
  • Gene Symbol: RPS7 (ENSG00000171863)
    Fold Change: 3.3
    Ensembl ID: ENSG00000171863
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.29
    Ensembl ID: ENSG00000080824
  • Gene Symbol: UBA52 (ENSG00000221983)
    Fold Change: 3.28
    Ensembl ID: ENSG00000221983
  • Gene Symbol: RPL7 (ENSG00000147604)
    Fold Change: 3.28
    Ensembl ID: ENSG00000147604
  • Gene Symbol: RPL27 (ENSG00000131469)
    Fold Change: 3.28
    Ensembl ID: ENSG00000131469
  • Gene Symbol: RPL29 (ENSG00000162244)
    Fold Change: 3.28
    Ensembl ID: ENSG00000162244
  • Gene Symbol: RPS9 (ENSG00000170889)
    Fold Change: 3.26
    Ensembl ID: ENSG00000170889
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 3.22
    Ensembl ID: ENSG00000198899
  • Gene Symbol: RPS20 (ENSG00000008988)
    Fold Change: 3.17
    Ensembl ID: ENSG00000008988
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 3.16
    Ensembl ID: ENSG00000198886
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.16
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 3.15
    Ensembl ID: ENSG00000198727
  • Gene Symbol: RPL39 (ENSG00000198918)
    Fold Change: 3.14
    Ensembl ID: ENSG00000198918
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 3.13
    Ensembl ID: ENSG00000196531
  • Gene Symbol: RPL18A (ENSG00000105640)
    Fold Change: 3.12
    Ensembl ID: ENSG00000105640
  • Gene Symbol: RPS25 (ENSG00000118181)
    Fold Change: 3.11
    Ensembl ID: ENSG00000118181
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.1
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RPL7A (ENSG00000148303)
    Fold Change: 3.08
    Ensembl ID: ENSG00000148303
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.06
    Ensembl ID: ENSG00000131143
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.04
    Ensembl ID: ENSG00000189403
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 3.03
    Ensembl ID: ENSG00000123349
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.02
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RPL4 (ENSG00000174444)
    Fold Change: 3.02
    Ensembl ID: ENSG00000174444
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3
    Ensembl ID: ENSG00000168028
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 3
    Ensembl ID: ENSG00000198840
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 3
    Ensembl ID: ENSG00000167658
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.97
    Ensembl ID: ENSG00000127184
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.96
    Ensembl ID: ENSG00000198888

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in neutrophil progenitor cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in neutrophil progenitor cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The neutrophil progenitor cell is characterized by its: * Expression of RPL13, RPLP1, and ACTB genes, which are involved in translation, ribosome biogenesis, and cytoskeleton organization. * Ability to differentiate into neutrophils, which is a critical process in the innate immune response. * Involvement in the development of the nervous system, the immune system, and the development of various tissues and organs. * Expression of proteins involved in cell signaling, such as robo receptors and Slits. * Ability to respond to stimuli, including amino acid deficiency, stress, and viral infections. * Involvement in the regulation of gene expression, including the regulation of Slits and Robos expression. * Ability to form a pool of free 40s subunits, which is essential for ribosome biogenesis. **Clinical Significance** The neutrophil progenitor cell has significant clinical implications, including: * Development of neutropenia, a condition characterized by an abnormally low count of neutrophils, which can increase the risk of infections. * Development of leukemia, a type of cancer that affects the blood and bone marrow. * Development of autoimmune disorders, such as rheumatoid arthritis, which can be triggered by an imbalance in the neutrophil-to-lymphocyte ratio. * Development of inflammatory diseases, such as atherosclerosis, which can be triggered by an imbalance in the neutrophil-to-lymphocyte ratio. * Development of cancer, including solid tumors and hematological malignancies, which can be triggered by an imbalance in the neutrophil-to-lymphocyte ratio. In addition, the neutrophil progenitor cell is involved in the development of various diseases, including: * Leukemia * Lymphoma * Multiple myeloma * Sickle cell disease * Thalassemia Overall, the neutrophil progenitor cell plays a critical role in the development of the immune system, the nervous system, and the development of various tissues and organs. Its dysregulation can lead to various diseases, including autoimmune disorders, inflammatory diseases, and cancer.