Details for: CL0000836

Cell ID: CL0000836

Cell Name: promyelocyte

Marker Score Threshold: 494
(Derived using integrated single-cell and genomic data)

Description: A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.6
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.55
    Ensembl ID: ENSG00000124172
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.52
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.51
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.3
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.29
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.22
    Ensembl ID: ENSG00000179218
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.2
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.17
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.14
    Ensembl ID: ENSG00000204472
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.14
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.04
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.04
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.97
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.94
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.93
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.91
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.91
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.89
    Ensembl ID: ENSG00000135218
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.81
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.77
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.75
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.74
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.71
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.69
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.68
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.67
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.66
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.64
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.64
    Ensembl ID: ENSG00000116459
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.63
    Ensembl ID: ENSG00000108561
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.62
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.62
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.62
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.61
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.61
    Ensembl ID: ENSG00000116489
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.6
    Ensembl ID: ENSG00000173372
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.55
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.53
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.49
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.49
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.47
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.47
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.46
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.42
    Ensembl ID: ENSG00000158578
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.4
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.39
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.37
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.35
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.34
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.33
    Ensembl ID: ENSG00000171552
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 1.31
    Ensembl ID: ENSG00000173369
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.27
    Ensembl ID: ENSG00000029534
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.27
    Ensembl ID: ENSG00000126247
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.23
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.21
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135046
  • Gene Symbol: C1QC (ENSG00000159189)
    Fold Change: 1.2
    Ensembl ID: ENSG00000159189
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.19
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BPGM (ENSG00000172331)
    Fold Change: 1.18
    Ensembl ID: ENSG00000172331
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.16
    Ensembl ID: ENSG00000071553
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.16
    Ensembl ID: ENSG00000142192
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.15
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.14
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.13
    Ensembl ID: ENSG00000112576
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.12
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004059
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.04
    Ensembl ID: ENSG00000130303
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.03
    Ensembl ID: ENSG00000101444
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.02
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.02
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1
    Ensembl ID: ENSG00000173020
Hovered Details

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Hovered Details

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**Key Characteristics** Promyelocytes are characterized by: 1. **Nuclear-to-cytoplasmic ratio**: Promyelocytes have a high nuclear-to-cytoplasmic ratio, which is a characteristic feature of immature white blood cells. 2. **Primary cytoplasmic granules**: Promyelocytes contain primary cytoplasmic granules, which are involved in the storage and release of antimicrobial peptides. 3. **Fucosyltransferase FUT4-positive**: Promyelocytes express fucosyltransferase FUT4, a glycosyltransferase enzyme involved in the synthesis of glycoproteins and glycolipids. 4. **CD33-positive**: Promyelocytes express CD33, a sialic acid-binding immunoglobulin-like lectin that is involved in cell adhesion and signaling. 5. **Integrin alpha-M-negative**: Promyelocytes lack integrin alpha-M, a transmembrane receptor involved in cell adhesion and migration. **Clinical Significance** Promyelocytes play a crucial role in the immune system, and their dysregulation can lead to various diseases, including: 1. **Leukemia**: Promyelocytes are involved in the development of certain types of leukemia, such as acute myeloid leukemia (AML). 2. **Infectious diseases**: Promyelocytes are involved in the immune response to infections, including bacterial and viral infections. 3. **Autoimmune diseases**: Promyelocytes can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cancer**: Promyelocytes can be involved in the development of certain types of cancer, such as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). In summary, promyelocytes are a type of immature white blood cell that plays a crucial role in the immune system. Their dysregulation can lead to various diseases, including leukemia, infectious diseases, autoimmune diseases, and cancer. Understanding the biology and clinical significance of promyelocytes is essential for the development of effective treatments for these diseases.