Details for: CL0000837

Cell ID: CL0000837

Cell Name: hematopoietic multipotent progenitor cell

Marker Score Threshold: 488
(Derived using integrated single-cell and genomic data)

Description: A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.

Synonyms: MPP, hemopoietic progenitor cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.14
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.79
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.74
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.63
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.59
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.59
    Ensembl ID: ENSG00000145741
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.55
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.5
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.44
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.44
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.43
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.34
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.26
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.14
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.14
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.13
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.02
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.01
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.01
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.98
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.94
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.93
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.93
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.91
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.84
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.81
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.78
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.78
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.77
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.76
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.74
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.73
    Ensembl ID: ENSG00000198931
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.73
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.64
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.63
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.61
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.61
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.61
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.6
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.58
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.55
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.53
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185650
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.51
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.51
    Ensembl ID: ENSG00000042493
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.5
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.48
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.47
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.46
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.45
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.44
    Ensembl ID: ENSG00000072778
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143799
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.42
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.4
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.37
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.37
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.36
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.36
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.34
    Ensembl ID: ENSG00000087088
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.32
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.31
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.28
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.26
    Ensembl ID: ENSG00000126247
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.25
    Ensembl ID: ENSG00000173020
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.23
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.19
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.17
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.15
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.15
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.14
    Ensembl ID: ENSG00000135046
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.12
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.12
    Ensembl ID: ENSG00000131100
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.11
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110987
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149823
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.07
    Ensembl ID: ENSG00000140299
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130208
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.05
    Ensembl ID: ENSG00000127837
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.05
    Ensembl ID: ENSG00000128595
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.04
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.02
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.02
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1
    Ensembl ID: ENSG00000117054
Hovered Details

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Hovered Details

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**Key Characteristics** * **Multipotent**: HMPCs have the ability to differentiate into multiple cell types, including blood cells, but are not capable of long-term self-renewal. * **CD34-positive**: HMPCs are marked by their positivity for the CD34 marker, which is a common marker for hematopoietic cells. * **Lack of lineage-specific surface markers**: HMPCs do not express lineage-specific surface markers, indicating their multipotency. * **Characterized by gene expression**: HMPCs are involved in the regulation of various cellular processes, including cell signaling, cytoskeleton organization, and gene expression. * **Regulate cellular processes**: HMPCs are involved in the regulation of various cellular processes, including cell signaling, cytoskeleton organization, and gene expression. **Clinical Significance** * **Hematopoietic disorders**: HMPCs are involved in the development of various hematopoietic disorders, including leukemia and lymphoma. * **Immunodeficiency**: HMPCs are essential for the proper functioning of the immune system, and defects in these cells can lead to immunodeficiency. * **Cancer research**: HMPCs are being studied as a potential target for cancer therapy, as they are involved in the regulation of cellular processes that are essential for cancer cell growth and survival. * **Regenerative medicine**: HMPCs are being explored as a potential source for regenerative medicine, as they have the ability to differentiate into multiple cell types and can be used to replace damaged or diseased cells. In conclusion, hematopoietic multipotent progenitor cells are a crucial component of the hematopoietic system, and their dysregulation can lead to various hematopoietic disorders. Understanding the key characteristics and clinical significance of HMPCs can provide valuable insights into the development of new therapeutic strategies for the treatment of hematopoietic disorders.