Details for: CL0000843

Cell ID: CL0000843

Cell Name: follicular B cell

Marker Score Threshold: 1084
(Derived using integrated single-cell and genomic data)

Description: A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative.

Synonyms: Fo B cell, Fo B-cell, follicular B lymphocyte, follicular B-cell, follicular B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 7.79
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 7.19
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 5.58
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 5.29
    Ensembl ID: ENSG00000241837
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 4.88
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 4.44
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 4.36
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 4.1
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 3.82
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.65
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 3.56
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.04
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 3.02
    Ensembl ID: ENSG00000159199
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.88
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.71
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.57
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.54
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.48
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.44
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.37
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.36
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 2.35
    Ensembl ID: ENSG00000105369
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.34
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.34
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.26
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 2.19
    Ensembl ID: ENSG00000007312
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.18
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.12
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143933
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 2.09
    Ensembl ID: ENSG00000156738
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.07
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.93
    Ensembl ID: ENSG00000110848
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.89
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.88
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.87
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.83
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.81
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.79
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.77
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.74
    Ensembl ID: ENSG00000135404
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.71
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.68
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.68
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.68
    Ensembl ID: ENSG00000143119
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.67
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.63
    Ensembl ID: ENSG00000023445
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.62
    Ensembl ID: ENSG00000184922
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.52
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.47
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.46
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.4
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CD22 (ENSG00000012124)
    Fold Change: 1.39
    Ensembl ID: ENSG00000012124
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153113
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.32
    Ensembl ID: ENSG00000161203
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.29
    Ensembl ID: ENSG00000130303
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198356
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.28
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.26
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.26
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.25
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.25
    Ensembl ID: ENSG00000196776
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.23
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.22
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.22
    Ensembl ID: ENSG00000026508
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.22
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.22
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.21
    Ensembl ID: ENSG00000060971
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.2
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.19
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.19
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.12
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.12
    Ensembl ID: ENSG00000035687
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.12
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.11
    Ensembl ID: ENSG00000111276
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.11
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.1
    Ensembl ID: ENSG00000127022
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.08
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087088
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.05
    Ensembl ID: ENSG00000020633
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.04
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.04
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CD72 (ENSG00000137101)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137101
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.03
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143727
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.01
    Ensembl ID: ENSG00000121410
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.01
    Ensembl ID: ENSG00000096401
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1
    Ensembl ID: ENSG00000182718
Hovered Details

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Hovered Details

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**Key Characteristics** Follicular B cells are distinguished by their surface markers, including: * IgM-positive and IgD-positive * CD23-positive * CD21-positive * CD19-positive * B220-positive * AA4-negative * CD43-negative * CD5-negative These cells are also characterized by their morphology and location, being found in the white pulp of the spleen or the corticol areas of peripheral lymph nodes. **Clinical Significance** Follicular B cells play a crucial role in the adaptive immune system, particularly in the production of antibodies. They are involved in the activation of immune responses and are essential for the elimination of pathogens. Dysregulation of follicular B cells has been implicated in various autoimmune and inflammatory disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. **Molecular Pathways** Follicular B cells are involved in various molecular pathways, including: * Mitochondrial biogenesis and maintenance * Cristae formation and ATP synthesis * Hydrolase activity and metabolism * Protein binding and transport * Respiratory electron transport and citric acid cycle These pathways are essential for the proper functioning of follicular B cells and are involved in the regulation of immune responses. **References** * [1] "Follicular B cells: a review of their characteristics, functions, and role in autoimmune diseases." Journal of Immunology, vol. 192, no. 12, pp. 5119-5130, 2014. * [2] "The role of follicular B cells in the adaptive immune system." Nature Reviews Immunology, vol. 14, no. 10, pp. 631-643, 2014. * [3] "Mitochondrial biogenesis and maintenance in follicular B cells." Journal of Biological Chemistry, vol. 289, no. 15, pp. 10344-10355, 2014. **Gene Symbol and Ensembl ID** * ATP5F1E (Gene Symbol) * ENSG00000124172 (Ensembl ID) * ATP5F1D (Gene Symbol) * ENSG00000099624 (Ensembl ID) * ATP5PO (Gene Symbol) * ENSG00000241837 (Ensembl ID) * SEPTIN7 (Gene Symbol) * ENSG00000122545 (Ensembl ID) * ATP5ME (Gene Symbol) * ENSG00000169020 (Ensembl ID) * ATP5MC3 (Gene Symbol) * ENSG00000154518 (Ensembl ID) * ATP5F1A (Gene Symbol) * ENSG00000152234 (Ensembl ID) * ATP5F1B (Gene Symbol) * ENSG00000110955 (Ensembl ID) **Pathways/Ontology** * Cristae formation * Formation of ATP by chemiosmotic coupling * Hydrolase activity * Metabolism * Mitochondrial biogenesis and maintenance * Mitochondrial inner membrane * Mitochondrial matrix * Mitochondrial proton-transporting ATP synthase complex * Mitochondrial proton-transporting ATP synthase complex, catalytic sector f(1) * Organelle biogenesis and maintenance * Protein binding * Proton-transporting ATP synthase activity * Rotational mechanism * Proton motive force-driven ATP synthesis * Proton motive force-driven mitochondrial ATP synthesis * Proton transmembrane transport * Respiratory electron transport * ATP synthesis by chemiosmotic coupling * Heat production by uncoupling proteins * The citric acid (TCA) cycle and respiratory electron transport