Details for: CL0000844

Cell ID: CL0000844

Cell Name: germinal center B cell

Marker Score Threshold: 608
(Derived using integrated single-cell and genomic data)

Description: A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation.

Synonyms: GC B cell, GC B lymphocyte, GC B-cell, GC B-lymphocyte, germinal center B lymphocyte, germinal center B-cell, germinal center B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.39
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 4.37
    Ensembl ID: ENSG00000019582
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.36
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 4.16
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 4.15
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.14
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 4.13
    Ensembl ID: ENSG00000133639
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 4.11
    Ensembl ID: ENSG00000156738
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.09
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.06
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 4.05
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 4
    Ensembl ID: ENSG00000105369
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 3.99
    Ensembl ID: ENSG00000007312
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.91
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.61
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.58
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.42
    Ensembl ID: ENSG00000099622
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.91
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.86
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.82
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD22 (ENSG00000012124)
    Fold Change: 2.79
    Ensembl ID: ENSG00000012124
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.77
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.69
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.69
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.63
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.51
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.5
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.5
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.47
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 2.37
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.33
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 2.33
    Ensembl ID: ENSG00000139193
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.32
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154723
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.27
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 2.25
    Ensembl ID: ENSG00000177455
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 2.24
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.16
    Ensembl ID: ENSG00000116459
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.16
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.14
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD72 (ENSG00000137101)
    Fold Change: 2.08
    Ensembl ID: ENSG00000137101
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.07
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD40 (ENSG00000101017)
    Fold Change: 2.05
    Ensembl ID: ENSG00000101017
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.03
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.94
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.8
    Ensembl ID: ENSG00000122705
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.79
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.77
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.71
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.71
    Ensembl ID: ENSG00000136573
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.7
    Ensembl ID: ENSG00000117091
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.69
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.65
    Ensembl ID: ENSG00000110987
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.59
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.57
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.56
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.5
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160014
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.46
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.44
    Ensembl ID: ENSG00000010671
  • Gene Symbol: BIK (ENSG00000100290)
    Fold Change: 1.43
    Ensembl ID: ENSG00000100290
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.4
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.39
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 1.36
    Ensembl ID: ENSG00000004468
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.36
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.34
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.34
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CKS2 (ENSG00000123975)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123975
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.31
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.29
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196839
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.28
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.24
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164615
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.22
    Ensembl ID: ENSG00000117054
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.22
    Ensembl ID: ENSG00000140379
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.19
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.14
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.12
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.11
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.1
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.06
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.05
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.04
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.04
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.04
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.01
    Ensembl ID: ENSG00000146731
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Rapid Cycling**: GC B cells are characterized by their rapid cell cycle, which allows them to undergo multiple rounds of proliferation and differentiation in response to antigen stimulation. 2. **Activation**: Upon activation, GC B cells express the surface molecule Ly77 (CD127) and undergo clonal expansion, leading to the production of large numbers of mature B cells. 3. **Germinal Center Location**: GC B cells are typically found in the germinal centers of lymph nodes, where they interact with T cells and undergo clonal expansion. 4. **T-Dependent Immune Response**: GC B cells are involved in T-dependent immune responses, where they interact with T cells to produce antibodies against pathogens. 5. **Expression of Surface Molecules**: GC B cells express a range of surface molecules, including CD19, CD20, CD21, and CD40, which are involved in their activation, proliferation, and differentiation. **Clinical Significance** 1. **Autoimmune Diseases**: Dysregulation of GC B cells has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Immunodeficiency Diseases**: GC B cells play a critical role in the adaptive immune response, and their dysregulation has been implicated in immunodeficiency diseases, such as X-linked agammaglobulinemia and Bruton's agammaglobulinemia. 3. **Cancer**: GC B cells have been implicated in the development of certain types of cancer, including lymphoma and leukemia. 4. **Infectious Diseases**: GC B cells are involved in the production of antibodies against pathogens, and their dysregulation has been implicated in various infectious diseases, including HIV and tuberculosis. 5. **Vaccine Development**: GC B cells are a critical component of the adaptive immune response, and their dysregulation has been implicated in the development of vaccines against pathogens. In summary, the Germinal Center B Cell is a critical component of the adaptive immune response, and its dysregulation has been implicated in a range of autoimmune, immunodeficiency, and infectious diseases. Understanding the biology and function of GC B cells is essential for the development of effective therapies for these diseases.