Details for: CL0000861

Cell ID: CL0000861

Cell Name: elicited macrophage

Marker Score Threshold: 6077
(Derived using integrated single-cell and genomic data)

Description: A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.

Synonyms: free macrophage, wandering histiocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 3.58
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.33
    Ensembl ID: ENSG00000169020
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.81
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.78
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.66
    Ensembl ID: ENSG00000124172
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.58
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.55
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.51
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.5
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.5
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.48
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.48
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.43
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.42
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.41
    Ensembl ID: ENSG00000132965
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.38
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.38
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.34
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 2.28
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.27
    Ensembl ID: ENSG00000104763
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 2.26
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.26
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.25
    Ensembl ID: ENSG00000072110
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.24
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.21
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 2.19
    Ensembl ID: ENSG00000102575
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 2.14
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.12
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.08
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.04
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.02
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.92
    Ensembl ID: ENSG00000103569
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.92
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.87
    Ensembl ID: ENSG00000111275
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152518
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.85
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.82
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.79
    Ensembl ID: ENSG00000170017
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.78
    Ensembl ID: ENSG00000087088
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.75
    Ensembl ID: ENSG00000116459
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.74
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.74
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.73
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.69
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.69
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.68
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.68
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.67
    Ensembl ID: ENSG00000114573
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.66
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.61
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.6
    Ensembl ID: ENSG00000012779
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.57
    Ensembl ID: ENSG00000122359
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.54
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.52
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.49
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.49
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.48
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AGRP (ENSG00000159723)
    Fold Change: 1.46
    Ensembl ID: ENSG00000159723
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.43
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.42
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.4
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.37
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.33
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.32
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.26
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.25
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.25
    Ensembl ID: ENSG00000213465
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.22
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.2
    Ensembl ID: ENSG00000140299
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.15
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148926
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.14
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.13
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.12
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.1
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.09
    Ensembl ID: ENSG00000015475
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.09
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.09
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.08
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.08
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.08
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.06
    Ensembl ID: ENSG00000156273
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138279
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.01
    Ensembl ID: ENSG00000165092
Hovered Details

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Hovered Details

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**Key Characteristics** Elicited macrophages are characterized by their: 1. **Surface markers**: CD11b, CD68, and F4/80 are specific markers used to identify elicited macrophages. 2. **Origin**: Elicited macrophages are derived from inflammatory monocytes. 3. **Function**: These cells play a crucial role in the inflammatory response, including the clearance of pathogens, presentation of antigens, and regulation of lipid metabolism. 4. **Gene expression**: Elicited macrophages express genes involved in cholesterol efflux, lipid metabolism, and other cellular processes. **Clinical Significance** Elicited macrophages have significant clinical implications, particularly in the context of: 1. **Infection and inflammation**: Elicited macrophages play a crucial role in the clearance of pathogens and the regulation of the inflammatory response. 2. **Lipid metabolism**: Elicited macrophages are involved in the regulation of lipid metabolism, which is critical in the development of atherosclerosis and other cardiovascular diseases. 3. **Autoimmune diseases**: Elicited macrophages can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, by presenting antigens and regulating the immune response. 4. **Cancer**: Elicited macrophages can contribute to the development and progression of cancer by promoting tumor growth and metastasis. **Pathways and Ontology** Elicited macrophages are involved in various cellular pathways, including: 1. **Cholesterol efflux**: Elicited macrophages express genes involved in cholesterol efflux, including APOC1. 2. **Lipid metabolism**: Elicited macrophages are involved in the regulation of lipid metabolism, including the clearance of chylomicron and very-low-density lipoprotein particles. 3. **Mitochondrial biogenesis**: Elicited macrophages express genes involved in mitochondrial biogenesis, including ATP5ME. 4. **Antigen presentation**: Elicited macrophages are involved in the presentation of antigens, including the processing and loading of peptide antigens onto MHC class I and II molecules. Overall, elicited macrophages play a critical role in the inflammatory response, lipid metabolism, and immune system regulation, making them an important target for therapeutic interventions in various diseases.