Details for: CL0000863

Cell ID: CL0000863

Cell Name: inflammatory macrophage

Marker Score Threshold: 310
(Derived using integrated single-cell and genomic data)

Description: An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity.

Synonyms: classically activated macrophage, M1 macrophage

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.19
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.11
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 3.01
    Ensembl ID: ENSG00000163631
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.89
    Ensembl ID: ENSG00000110245
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.42
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.38
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.27
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.26
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.24
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 2.22
    Ensembl ID: ENSG00000158874
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.12
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.04
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.01
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.99
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.95
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 1.78
    Ensembl ID: ENSG00000084674
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.78
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.75
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.7
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.69
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.68
    Ensembl ID: ENSG00000185650
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 1.67
    Ensembl ID: ENSG00000106927
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.67
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172482
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.64
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.64
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.64
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.63
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.62
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 1.61
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.61
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.6
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.6
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.6
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 1.58
    Ensembl ID: ENSG00000091583
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.57
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.56
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.53
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.52
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.47
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.47
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.46
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.41
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.38
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.35
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.35
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.33
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.32
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.32
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.32
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.31
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.3
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.28
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.28
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.26
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.25
    Ensembl ID: ENSG00000135744
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.24
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.24
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.21
    Ensembl ID: ENSG00000163399
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.21
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.2
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.18
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.15
    Ensembl ID: ENSG00000146731
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.14
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.14
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.09
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126247
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 1.08
    Ensembl ID: ENSG00000113600
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.08
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.06
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110651
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.05
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160710
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143799
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.04
    Ensembl ID: ENSG00000117601
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.03
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.02
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.01
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1
    Ensembl ID: ENSG00000004059
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: N/A
    Ensembl ID: ENSG00000177105
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **High levels of pro-inflammatory cytokines**: Inflammatory macrophages produce a range of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, which promote inflammation and activate other immune cells. 2. **Reactive oxygen species (ROS) and nitric oxide (NO) production**: Inflammatory macrophages produce ROS and NO, which are toxic to pathogens and contribute to the destruction of foreign particles. 3. **Phagocytic activity**: Inflammatory macrophages are capable of phagocytosing foreign particles, including bacteria, viruses, and dead cells. 4. **Antigen presentation**: Inflammatory macrophages present antigens to T-cells, which triggers an immune response and activates the adaptive immune system. 5. **Expression of surface receptors**: Inflammatory macrophages express a range of surface receptors, including Toll-like receptors (TLRs), which recognize pathogens and activate the innate immune response. **Clinical Significance** 1. **Inflammatory diseases**: Inflammatory macrophages play a key role in the pathogenesis of inflammatory diseases, including arthritis, atherosclerosis, and inflammatory bowel disease. 2. **Infection and sepsis**: Inflammatory macrophages are important in the defense against infection and sepsis, but an overactive response can contribute to tissue damage and organ dysfunction. 3. **Cancer**: Inflammatory macrophages have been implicated in the development and progression of cancer, particularly in the case of tumor-associated macrophages. 4. **Neurological disorders**: Inflammatory macrophages have been implicated in the pathogenesis of neurological disorders, including multiple sclerosis and Alzheimer's disease. 5. **Immunotherapy**: Inflammatory macrophages are a target for immunotherapy, as they can be modulated to enhance the immune response against cancer and infectious diseases. In conclusion, the inflammatory macrophage is a key player in the inflammatory response and is involved in a range of diseases and disorders. Understanding the biology of inflammatory macrophages is essential for the development of effective therapies for these conditions.