Details for: CL0000878

Cell ID: CL0000878

Cell Name: central nervous system macrophage

Marker Score Threshold: 497
(Derived using integrated single-cell and genomic data)

Description: A tissue-resident macrophage found in the central nervous system.

Synonyms: CNS macrophage

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.67
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.53
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.38
    Ensembl ID: ENSG00000140836
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.31
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 3.28
    Ensembl ID: ENSG00000136250
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3.27
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 3.22
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 3.13
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.08
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3
    Ensembl ID: ENSG00000185650
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.77
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.56
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.5
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.46
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.37
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 2.31
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.25
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.18
    Ensembl ID: ENSG00000130203
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 2.12
    Ensembl ID: ENSG00000100280
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 2.08
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.98
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.94
    Ensembl ID: ENSG00000047648
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.9
    Ensembl ID: ENSG00000169100
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.9
    Ensembl ID: ENSG00000100077
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.87
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.84
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.82
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.74
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.69
    Ensembl ID: ENSG00000171791
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.66
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.62
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.57
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.56
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ADCY7 (ENSG00000121281)
    Fold Change: 1.55
    Ensembl ID: ENSG00000121281
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.53
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.53
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.53
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.49
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.48
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.47
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.44
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.43
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.43
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.42
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APOC2 (ENSG00000234906)
    Fold Change: 1.41
    Ensembl ID: ENSG00000234906
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.4
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.4
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.38
    Ensembl ID: ENSG00000097007
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.36
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.34
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.33
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.32
    Ensembl ID: ENSG00000198363
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.3
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.3
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.29
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.28
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.26
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.26
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.25
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.25
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.25
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.24
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.22
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.21
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.19
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.18
    Ensembl ID: ENSG00000175054
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.18
    Ensembl ID: ENSG00000102699
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.14
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.12
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.11
    Ensembl ID: ENSG00000134982
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.11
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.11
    Ensembl ID: ENSG00000113273
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.1
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.1
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.09
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.09
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.04
    Ensembl ID: ENSG00000185883
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.04
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.03
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.03
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APAF1 (ENSG00000120868)
    Fold Change: 1.02
    Ensembl ID: ENSG00000120868
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143799
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Antigen Presentation**: CNS macrophages express MHC class I and II molecules on their surface, which allow them to present antigens to T-cells and other immune cells. 2. **Immune Regulation**: CNS macrophages modulate the immune response by producing cytokines, chemokines, and other signaling molecules that regulate the activity of other immune cells. 3. **Cellular Signaling**: CNS macrophages respond to a variety of signaling molecules, including growth factors, cytokines, and chemokines, which regulate their behavior and function. 4. **Antigen Processing**: CNS macrophages process and present antigens to T-cells, which is essential for the development of immune responses against pathogens and other foreign substances. 5. **Tissue-Resident**: CNS macrophages are tissue-resident, meaning they are resident cells of the CNS and do not circulate in the bloodstream. **Clinical Significance** 1. **Neuroinflammatory Disorders**: CNS macrophages play a key role in neuroinflammatory disorders, such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. 2. **Immune-Mediated Neurological Disorders**: CNS macrophages contribute to immune-mediated neurological disorders, such as Guillain-Barré syndrome and neuromyelitis optica. 3. **Cancer**: CNS macrophages can contribute to cancer development and progression by regulating the immune response and promoting tumor growth and metastasis. 4. **Infectious Diseases**: CNS macrophages play a critical role in the clearance of pathogens from the CNS, and dysfunction of these cells can contribute to the development of infectious diseases, such as meningitis and encephalitis. In conclusion, the CNS macrophage is a complex cell type that plays a critical role in maintaining the health and function of the CNS. Understanding the biology and function of CNS macrophages is essential for the development of novel therapeutic strategies for neuroinflammatory and immune-mediated neurological disorders.