Details for: CL0000879

Cell ID: CL0000879

Cell Name: meningeal macrophage

Marker Score Threshold: 282
(Derived using integrated single-cell and genomic data)

Description: A border associated macrophage that is part of a meninx. This macrophage type is elongated and amoeboid spindle-shaped with limited mobility. This macrophage is highly phagocytic, expresses scavenger receptors, has dynamic protrusions and extends its processes during inflammation.

Synonyms: subdural leptomeningeal macrophage, subdural meningeal macrophage, MM, MnMΦ, sdΜΦ

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.92
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.39
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.29
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.28
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.1
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.08
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.99
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.84
    Ensembl ID: ENSG00000164919
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.82
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.74
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.73
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.68
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.63
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.52
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.51
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.5
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.4
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.28
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.28
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.23
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.22
    Ensembl ID: ENSG00000213719
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.21
    Ensembl ID: ENSG00000067082
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.18
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.05
    Ensembl ID: ENSG00000172270
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.95
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.95
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.92
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.9
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.9
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.82
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.79
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.75
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.74
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.72
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.7
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.68
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.67
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.62
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.62
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.6
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.6
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.59
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.58
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.56
    Ensembl ID: ENSG00000182718
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.56
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.54
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.49
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.49
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.47
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.47
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.43
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.38
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.37
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.37
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.36
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.35
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.34
    Ensembl ID: ENSG00000112576
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.33
    Ensembl ID: ENSG00000115307
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.32
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.31
    Ensembl ID: ENSG00000175416
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.31
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.3
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.25
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.25
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.24
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.18
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.16
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.15
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.14
    Ensembl ID: ENSG00000131100
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177879
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177105
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.12
    Ensembl ID: ENSG00000109861
  • Gene Symbol: COMT (ENSG00000093010)
    Fold Change: 1.12
    Ensembl ID: ENSG00000093010
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.07
    Ensembl ID: ENSG00000153922
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.07
    Ensembl ID: ENSG00000183255
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.06
    Ensembl ID: ENSG00000127837
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.04
    Ensembl ID: ENSG00000196954
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164692
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.02
    Ensembl ID: ENSG00000113328
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177697
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1
    Ensembl ID: ENSG00000111276
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: N/A
    Ensembl ID: ENSG00000221869
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Morphology**: Meningeal macrophages are elongated and amoeboid spindle-shaped, with limited mobility. 2. **Phagocytic activity**: High phagocytic activity, allowing them to engulf and eliminate pathogens and debris. 3. **Scavenger receptors**: Express scavenger receptors, facilitating the uptake of extracellular ligands. 4. **Dynamic protrusions**: Extend dynamic protrusions, enabling them to interact with their environment and respond to inflammatory signals. 5. **Location**: Associated with the meninges, the protective membranes surrounding the CNS. **Clinical Significance** 1. **CNS infections**: Meningeal macrophages play a crucial role in the immune response to CNS infections, such as meningitis and encephalitis. 2. **Neurodegenerative diseases**: Abnormalities in meningeal macrophage function have been implicated in neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. 3. **Inflammatory responses**: Meningeal macrophages contribute to the development of inflammatory responses in the CNS, which can lead to tissue damage and dysfunction. 4. **Immunotherapy**: Meningeal macrophages have been explored as a target for immunotherapy in the treatment of CNS diseases, including cancer and infectious diseases. 5. **Neuroinflammation**: Meningeal macrophages are involved in the regulation of neuroinflammation, which is a key component of CNS diseases. **Genes and Pathways** Meningeal macrophages are associated with the following genes and pathways: 1. **B2M**: Gene symbol, involved in the regulation of immune responses. 2. **ACTB**: Gene symbol, involved in the regulation of actin cytoskeleton dynamics. 3. **Adaptive immune system**: Pathway, involved in the regulation of immune responses. 4. **Amyloid fiber formation**: Pathway, involved in the regulation of amyloid protein deposition. 5. **Antigen presentation**: Pathway, involved in the regulation of antigen presentation and immune responses. In conclusion, meningeal macrophages play a critical role in the immune response, particularly in the context of CNS infections and diseases. Their unique morphology, phagocytic activity, and expression of scavenger receptors make them important targets for immunotherapy and the regulation of neuroinflammation.