Details for: CL0000894

Cell ID: CL0000894

Cell Name: DN1 thymic pro-T cell

Marker Score Threshold: 310
(Derived using integrated single-cell and genomic data)

Description: A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative.

Synonyms: DN1 thymic pro-T lymphocyte, DN1 thymic pro-T-cell, DN1 thymic pro-T-lymphocyte, DN1 thymic progenitor T cell, DN1 thymocyte, double negative 1, preT.DN1.Th

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.04
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.02
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.01
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.98
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.97
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.96
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.93
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.93
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.92
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.89
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.85
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.61
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.59
    Ensembl ID: ENSG00000135046
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.57
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.54
    Ensembl ID: ENSG00000143933
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 2.44
    Ensembl ID: ENSG00000057657
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.4
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.38
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.37
    Ensembl ID: ENSG00000134825
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.35
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.32
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 2.3
    Ensembl ID: ENSG00000109321
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 2.28
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.27
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.1
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.07
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.05
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.03
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.92
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.87
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.87
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.87
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.86
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.85
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.85
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.82
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.81
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.79
    Ensembl ID: ENSG00000132965
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.78
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.78
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.78
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.68
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.66
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.65
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.63
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.61
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.57
    Ensembl ID: ENSG00000171791
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.56
    Ensembl ID: ENSG00000147872
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.56
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.55
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.53
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.51
    Ensembl ID: ENSG00000116459
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.49
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.47
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.45
    Ensembl ID: ENSG00000064012
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.44
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.43
    Ensembl ID: ENSG00000197043
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.43
    Ensembl ID: ENSG00000184922
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152495
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160014
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.36
    Ensembl ID: ENSG00000173020
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.33
    Ensembl ID: ENSG00000119138
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.32
    Ensembl ID: ENSG00000126247
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.31
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.3
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.29
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.28
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.28
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.28
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.25
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.24
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.22
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.2
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.2
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.13
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.13
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.13
    Ensembl ID: ENSG00000115307
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.1
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.09
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.09
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.05
    Ensembl ID: ENSG00000058668
Hovered Details

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Hovered Details

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**Key Characteristics** The DN1 thymic pro-T cell has several key characteristics that distinguish it from other types of T cells: 1. **CD4-negative and CD8-negative phenotype**: The DN1 thymic pro-T cell lacks the CD4 and CD8 co-receptors, which are essential for the development and selection of T cells in the thymus. 2. **CD44-positive phenotype**: The DN1 thymic pro-T cell expresses the CD44 molecule, which is involved in cell-cell interactions and the regulation of T cell development. 3. **CD25-negative phenotype**: The DN1 thymic pro-T cell lacks the CD25 molecule, which is involved in the regulation of T cell development and function. 4. **Expression of actin cytoskeleton genes**: The DN1 thymic pro-T cell expresses genes involved in the regulation of the actin cytoskeleton, such as ACTB. 5. **Involvement in cell-cell interactions**: The DN1 thymic pro-T cell is involved in cell-cell interactions, including the regulation of T cell development and the formation of the thymic microenvironment. **Clinical Significance** The DN1 thymic pro-T cell plays a crucial role in the development and selection of T cells in the thymus. Abnormalities in the function or regulation of the DN1 thymic pro-T cell have been implicated in various immune disorders, including: 1. **Immunodeficiency diseases**: Abnormalities in the development or function of the DN1 thymic pro-T cell have been implicated in immunodeficiency diseases, such as severe combined immunodeficiency (SCID). 2. **Autoimmune diseases**: Abnormalities in the function or regulation of the DN1 thymic pro-T cell have been implicated in autoimmune diseases, such as type 1 diabetes and multiple sclerosis. 3. **Cancer**: Abnormalities in the function or regulation of the DN1 thymic pro-T cell have been implicated in cancer, including T cell lymphoma and leukemia. In summary, the DN1 thymic pro-T cell is a crucial stage in the development of thymocytes, and its function and regulation are essential for the proper formation of the immune system. Abnormalities in the function or regulation of the DN1 thymic pro-T cell have been implicated in various immune disorders, including immunodeficiency diseases, autoimmune diseases, and cancer.