Details for: CL0000895

Cell ID: CL0000895

Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell

Marker Score Threshold: 1716
(Derived using integrated single-cell and genomic data)

Description: An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low.

Synonyms: naive CD4+ T cell, T.4Nve.Sp, Th0, naive thymus-derived CD4-positive, alpha-beta T lymphocyte, naive thymus-derived CD4-positive, alpha-beta T-cell, naive thymus-derived CD4-positive, alpha-beta T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 6.23
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.19
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.46
    Ensembl ID: ENSG00000124172
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.46
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 4.29
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.28
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 4.08
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.03
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.46
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.38
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.17
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.05
    Ensembl ID: ENSG00000149925
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.04
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.99
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.95
    Ensembl ID: ENSG00000198851
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.89
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.82
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.62
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.53
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.48
    Ensembl ID: ENSG00000116824
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.42
    Ensembl ID: ENSG00000077549
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.39
    Ensembl ID: ENSG00000134825
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.36
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.35
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.32
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.24
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.23
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.19
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.19
    Ensembl ID: ENSG00000160654
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.1
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.1
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.07
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.06
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.05
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.9
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.88
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.82
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.81
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.79
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.76
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.73
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.72
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.71
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 1.69
    Ensembl ID: ENSG00000013725
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116459
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.63
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.63
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.61
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.6
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.59
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.58
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.57
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.55
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.54
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.54
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.5
    Ensembl ID: ENSG00000139193
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165272
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.49
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.47
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.46
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 1.45
    Ensembl ID: ENSG00000110448
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.43
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.42
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.41
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198898
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.39
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.34
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.33
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.31
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.31
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.28
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.26
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.23
    Ensembl ID: ENSG00000152495
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.19
    Ensembl ID: ENSG00000089820
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CD4 (ENSG00000010610)
    Fold Change: 1.18
    Ensembl ID: ENSG00000010610
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.15
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.13
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CD40LG (ENSG00000102245)
    Fold Change: 1.12
    Ensembl ID: ENSG00000102245
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.1
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.1
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.04
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134480
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Phenotype**: CCR7-positive, CD127-positive, and CD62L-positive, CD25-negative, CD62L-high, and CD44-low. 2. **Development**: Develops in the thymus. 3. **Function**: Plays a crucial role in the adaptive immune system. 4. **Genes**: SLC25A6, ACTB, ATP5F1E, and B2M. 5. **Pathways/Ontology**: Involved in various cellular processes, including apoptosis, protein metabolism, and mitochondrial function. **Clinical Significance** 1. **Immune System**: This cell type plays a crucial role in the adaptive immune system, which is essential for fighting off infections and diseases. 2. **Autoimmune Diseases**: Dysregulation of this cell type can lead to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 3. **Cancer**: Abnormal expression of this cell type can contribute to the development of cancer. 4. **Vaccine Development**: Understanding the function and regulation of this cell type is essential for the development of effective vaccines. 5. **Immunotherapy**: Targeting this cell type can be a potential therapeutic strategy for treating autoimmune diseases and cancer. **Diseases Associated with this Cell Type** 1. **Multiple Sclerosis**: Dysregulation of this cell type has been linked to multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. 2. **Type 1 Diabetes**: Abnormal expression of this cell type has been associated with type 1 diabetes, an autoimmune disease that affects the pancreas. 3. **Rheumatoid Arthritis**: This cell type has been implicated in the development of rheumatoid arthritis, an autoimmune disease that affects the joints. 4. **Cancer**: Abnormal expression of this cell type has been linked to various types of cancer, including breast cancer and lung cancer. **Future Research Directions** 1. **Understanding the Regulation of this Cell Type**: Further research is needed to understand the regulation of this cell type and how it is affected by various diseases. 2. **Development of Therapeutic Strategies**: Targeting this cell type could be a potential therapeutic strategy for treating autoimmune diseases and cancer. 3. **Immunotherapy**: Understanding the function and regulation of this cell type is essential for the development of effective immunotherapies.