Details for: CL0000897

Cell ID: CL0000897

Cell Name: CD4-positive, alpha-beta memory T cell

Marker Score Threshold: 586
(Derived using integrated single-cell and genomic data)

Description: A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell.

Synonyms: CD4-positive, alpha-beta memory T lymphocyte, CD4-positive, alpha-beta memory T-cell, CD4-positive, alpha-beta memory T-lymphocyte, T4.Mem.Sp

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.2
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.2
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.95
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.88
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.82
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.8
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.74
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.73
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.48
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.48
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 3.46
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.43
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 3.2
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 3.17
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.12
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 3.01
    Ensembl ID: ENSG00000077549
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.85
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.81
    Ensembl ID: ENSG00000132965
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.69
    Ensembl ID: ENSG00000198931
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.61
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.6
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.55
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.52
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.52
    Ensembl ID: ENSG00000182718
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.37
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.37
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.32
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.21
    Ensembl ID: ENSG00000197043
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 2.2
    Ensembl ID: ENSG00000057657
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.2
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.14
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.08
    Ensembl ID: ENSG00000160654
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 2.03
    Ensembl ID: ENSG00000013725
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.02
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.01
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.98
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.98
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.94
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.89
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.85
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.82
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.81
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.76
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.76
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.72
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.65
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.65
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.63
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD40LG (ENSG00000102245)
    Fold Change: 1.63
    Ensembl ID: ENSG00000102245
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.63
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.61
    Ensembl ID: ENSG00000173762
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.61
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.57
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.56
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.53
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.52
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.49
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.46
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.45
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.45
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.43
    Ensembl ID: ENSG00000128272
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.42
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.42
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.37
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.37
    Ensembl ID: ENSG00000069849
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.37
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.34
    Ensembl ID: ENSG00000070961
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.31
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.27
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.25
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.24
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 1.23
    Ensembl ID: ENSG00000110448
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.22
    Ensembl ID: ENSG00000196954
  • Gene Symbol: TNFSF8 (ENSG00000106952)
    Fold Change: 1.21
    Ensembl ID: ENSG00000106952
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.2
    Ensembl ID: ENSG00000155366
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.18
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.17
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.16
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.15
    Ensembl ID: ENSG00000115307
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.15
    Ensembl ID: ENSG00000147872
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.12
    Ensembl ID: ENSG00000064012
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.11
    Ensembl ID: ENSG00000131100
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.08
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.08
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.07
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.04
    Ensembl ID: ENSG00000139193
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.04
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.03
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.01
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149311
Hovered Details

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Hovered Details

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**Key Characteristics** * **CD4-positive**: These cells express the CD4 surface protein, which is a marker for helper T cells. * **Alpha-beta memory T cell**: The cell has undergone extensive differentiation and maturation to become a long-lasting memory cell. * **Synonyms**: CD4-positive, alpha-beta memory T lymphocyte, CD4-positive, alpha-beta memory T-cell, CD4-positive, alpha-beta memory T-lymphocyte. * **Gene Symbol**: ACTB (Actin beta). * **Ensembl ID**: ENSG00000075624. **Clinical Significance** CD4-positive, alpha-beta memory T cells play a crucial role in the adaptive immune system, providing a rapid and effective response to infections and other foreign substances. These cells are involved in various clinical conditions, including: * **HIV infection**: CD4-positive T cells are depleted in HIV-infected individuals, leading to immunosuppression and increased susceptibility to opportunistic infections. * **Autoimmune diseases**: Memory T cells can contribute to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, by recognizing and responding to self-antigens. * **Cancer**: Memory T cells can recognize and target cancer cells, making them a potential therapeutic target for cancer immunotherapy. * **Infectious diseases**: CD4-positive, alpha-beta memory T cells can recognize and respond to pathogens, such as bacteria, viruses, and parasites, providing a rapid and effective response to infections. In summary, CD4-positive, alpha-beta memory T cells are a crucial component of the adaptive immune system, providing a rapid and effective response to infections and other foreign substances. Understanding the structure, function, and clinical significance of these cells is essential for the development of effective immunotherapies and treatments for various diseases. **Pathways/Ontology** CD4-positive, alpha-beta memory T cells are involved in various cellular processes, including: * **Adherens junction assembly**: The cell's ability to form adherens junctions is essential for its function and survival. * **Apical junction complex**: The cell's apical junction complex is involved in the regulation of cell-cell interactions and signaling. * **Apical protein localization**: The cell's ability to localize proteins to the apical surface is essential for its function and survival. * **B-wich complex positively regulates rrna expression**: The B-wich complex is involved in the regulation of rrna expression, which is essential for cell growth and proliferation. * **Bbaf complex**: The Bbaf complex is involved in the regulation of cell growth and proliferation. * **Blood microparticle**: The cell's ability to produce blood microparticles is essential for its function and survival. * **Brahma complex**: The Brahma complex is involved in the regulation of cell growth and proliferation. * **Brush border**: The cell's brush border is involved in the regulation of cell growth and proliferation. * **Calyx of held**: The cell's calyx of held is involved in the regulation of cell growth and proliferation. * **Cell-cell communication**: The cell's ability to communicate with other cells is essential for its function and survival. * **Cell-extracellular matrix interactions**: The cell's ability to interact with the extracellular matrix is essential for its function and survival. * **Chaperonin-mediated protein folding**: The cell's ability to fold proteins is essential for its function and survival. These pathways and ontologies highlight the complex and multifaceted nature of CD4-positive, alpha-beta memory T cells, and demonstrate the importance of understanding their structure, function, and clinical significance.