Details for: CL0000898

Cell ID: CL0000898

Cell Name: naive T cell

Marker Score Threshold: 644
(Derived using integrated single-cell and genomic data)

Description: Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.

Synonyms: naive T lymphocyte, naive T-cell, naive T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 5.67
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.91
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 4.55
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.43
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.17
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 4.16
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 4.11
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.05
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.98
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 3.91
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.67
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.59
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.36
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 3.29
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.25
    Ensembl ID: ENSG00000198851
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.11
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 3.1
    Ensembl ID: ENSG00000116824
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.82
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.8
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.79
    Ensembl ID: ENSG00000160654
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.79
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.7
    Ensembl ID: ENSG00000173762
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.68
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.63
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.63
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.48
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.45
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.37
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CCR7 (ENSG00000126353)
    Fold Change: 2.33
    Ensembl ID: ENSG00000126353
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.32
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.3
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.23
    Ensembl ID: ENSG00000070831
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.19
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.15
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.1
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.1
    Ensembl ID: ENSG00000019582
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.01
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.95
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.9
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.84
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.84
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.82
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.79
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.74
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.66
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.65
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.64
    Ensembl ID: ENSG00000139193
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.6
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.6
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.59
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.58
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.57
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.52
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.52
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.51
    Ensembl ID: ENSG00000110955
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.5
    Ensembl ID: ENSG00000168421
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.49
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.48
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.46
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 1.46
    Ensembl ID: ENSG00000013725
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.45
    Ensembl ID: ENSG00000132965
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.39
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.34
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.33
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.33
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.32
    Ensembl ID: ENSG00000013441
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.32
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.31
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.27
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.26
    Ensembl ID: ENSG00000111276
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.25
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.24
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.23
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116489
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.16
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.14
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.13
    Ensembl ID: ENSG00000152495
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.12
    Ensembl ID: ENSG00000165527
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.1
    Ensembl ID: ENSG00000020633
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.07
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.07
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD28 (ENSG00000178562)
    Fold Change: 1.07
    Ensembl ID: ENSG00000178562
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.06
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.05
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.05
    Ensembl ID: ENSG00000109861
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.02
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.02
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.01
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1
    Ensembl ID: ENSG00000164615
Hovered Details

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Hovered Details

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**Key Characteristics** * Phenotype: CCR7-positive, CD45RA-positive, and CD127-positive, with the absence of CD25, CD62L, and CD44. * Function: Activates, proliferates, and differentiates T cells. * Role in immune response: Involved in the activation, proliferation, and differentiation of T cells, and plays a key role in the immune response against pathogens and tumors. * Gene expression: B2M gene symbol, involved in adaptive immune system, amyloid fiber formation, and antigen presentation. * Pathways: Involved in adaptive immune system, antigen processing and presentation, and cytokine signaling in immune system. * Synonyms: Naive T lymphocyte, Naive T-cell, Naive T-lymphocyte. **Clinical Significance** * Naive T cells play a crucial role in the adaptive immune response, and their dysfunction can lead to immunodeficiency and increased susceptibility to infections. * Understanding the function and regulation of naive T cells is essential for the development of effective immunotherapies for cancer and infectious diseases. * The study of naive T cells can provide insights into the mechanisms of immune tolerance and the development of autoimmune diseases. * Naive T cells are also involved in the pathogenesis of various diseases, including HIV-1 infection, tuberculosis, and multiple sclerosis. * The development of vaccines and immunotherapies that target naive T cells can provide new strategies for the prevention and treatment of infectious diseases and cancer. Overall, the study of naive T cells is crucial for understanding the adaptive immune response and the development of effective immunotherapies for various diseases.