Details for: CL0000899

Cell ID: CL0000899

Cell Name: T-helper 17 cell

Marker Score Threshold: 656
(Derived using integrated single-cell and genomic data)

Description: CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17.

Synonyms: IL-17-producing CD4+ T helper, T helper cells type 17, T(H)-17 cell, Th17 CD4+ T cell, Th17 T cell, Th17 T lymphocyte, Th17 T-cell, Th17 T-lymphocyte, Th17 cell, helper T cell type 17

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: TNFRSF8 (ENSG00000120949)
    Fold Change: 5.89
    Ensembl ID: ENSG00000120949
  • Gene Symbol: CD86 (ENSG00000114013)
    Fold Change: 3.94
    Ensembl ID: ENSG00000114013
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.83
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.56
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.51
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.44
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.43
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.41
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.39
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.33
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.27
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD80 (ENSG00000121594)
    Fold Change: 2.12
    Ensembl ID: ENSG00000121594
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CDC25A (ENSG00000164045)
    Fold Change: 2.11
    Ensembl ID: ENSG00000164045
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.1
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD33 (ENSG00000105383)
    Fold Change: 2.05
    Ensembl ID: ENSG00000105383
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.04
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.01
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.92
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.89
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.85
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CBS (ENSG00000160200)
    Fold Change: 1.82
    Ensembl ID: ENSG00000160200
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.73
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.72
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.69
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.68
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.66
    Ensembl ID: ENSG00000213719
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.6
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.58
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.54
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.53
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.5
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.49
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.44
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.43
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.42
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.37
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.36
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.35
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.34
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CDC25C (ENSG00000158402)
    Fold Change: 1.34
    Ensembl ID: ENSG00000158402
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.33
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.32
    Ensembl ID: ENSG00000161203
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.32
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.32
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.3
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.29
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.25
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.25
    Ensembl ID: ENSG00000154518
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.25
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.24
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.24
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.22
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.21
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.19
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.19
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.18
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122705
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.16
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.15
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.14
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.14
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.13
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.12
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.11
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.09
    Ensembl ID: ENSG00000111642
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.08
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.07
    Ensembl ID: ENSG00000112576
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.05
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.03
    Ensembl ID: ENSG00000084234
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.03
    Ensembl ID: ENSG00000147872
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.03
    Ensembl ID: ENSG00000105254
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.02
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.01
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.01
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: C4BPB (ENSG00000123843)
    Fold Change: 1.01
    Ensembl ID: ENSG00000123843
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD4-positive, alpha-beta T cell**: Th17 cells are a subset of CD4-positive T cells, which are a key component of the adaptive immune response. 2. **RORγt-positive**: The transcription factor RORγt is essential for the development and function of Th17 cells. 3. **CXCR3-negative**: Th17 cells do not express the chemokine receptor CXCR3, which is typically associated with Th1 cells. 4. **CCR6-positive**: Th17 cells express the chemokine receptor CCR6, which is involved in the recruitment of these cells to sites of inflammation. 5. **IL-17 production**: Th17 cells are characterized by their ability to produce the cytokine IL-17, which plays a key role in inflammatory responses. **Clinical Significance** 1. **Fungal infections**: Th17 cells are essential for defending against fungal infections, such as candidiasis and aspergillosis. 2. **Autoimmune diseases**: Th17 cells have been implicated in various autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and psoriasis. 3. **Inflammatory responses**: Th17 cells play a key role in inflammatory responses, including those involved in asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). 4. **Cancer**: Th17 cells have been shown to promote tumor progression and metastasis in certain types of cancer, including breast and lung cancer. **Molecular Mechanisms** 1. **RORγt signaling**: The transcription factor RORγt regulates the expression of IL-17 and other cytokines involved in Th17 cell function. 2. **IL-17 production**: IL-17 is produced by Th17 cells through the action of the transcription factor RORγt and the presence of the enzyme IL-17A. 3. **CXCR6 signaling**: The chemokine receptor CCR6 is involved in the recruitment of Th17 cells to sites of inflammation. 4. **TGF-β signaling**: TGF-β is a cytokine that regulates Th17 cell differentiation and function. In conclusion, Th17 cells are a crucial component of the adaptive immune response, playing a key role in defending against fungal and bacterial infections, as well as in autoimmune diseases and inflammatory responses. Understanding the molecular mechanisms underlying Th17 cell function is essential for the development of novel therapeutic strategies for these diseases.