Details for: CL0000900

Cell ID: CL0000900

Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell

Marker Score Threshold: 1786
(Derived using integrated single-cell and genomic data)

Description: A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.

Synonyms: naive CD8+ T cell, naive thymus-dervied CD8-positive, alpha-beta T lymphocyte, naive thymus-dervied CD8-positive, alpha-beta T-cell, naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte, T.8Nve.Sp

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.91
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.89
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.73
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.63
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.57
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.55
    Ensembl ID: ENSG00000111348
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.34
    Ensembl ID: ENSG00000166710
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.13
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.11
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.05
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.02
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 3
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.93
    Ensembl ID: ENSG00000143933
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.89
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.7
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.61
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.53
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.51
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.45
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.45
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.43
    Ensembl ID: ENSG00000112576
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.42
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.41
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.35
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.26
    Ensembl ID: ENSG00000160654
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.25
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.17
    Ensembl ID: ENSG00000122359
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 2.17
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.14
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.13
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.1
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.06
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.06
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.98
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.98
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.98
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.95
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.94
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.92
    Ensembl ID: ENSG00000136717
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.87
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.82
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.78
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.76
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.76
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.75
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.72
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.71
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.69
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.66
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.61
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.54
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.51
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.5
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.48
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.47
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.47
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.47
    Ensembl ID: ENSG00000152495
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.46
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.46
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.43
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.42
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 1.4
    Ensembl ID: ENSG00000110448
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.37
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.36
    Ensembl ID: ENSG00000114423
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.34
    Ensembl ID: ENSG00000089820
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149823
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.3
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.27
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.27
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.23
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.21
    Ensembl ID: ENSG00000118971
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.17
    Ensembl ID: ENSG00000121410
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.15
    Ensembl ID: ENSG00000113328
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.13
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.13
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.1
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140299
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.09
    Ensembl ID: ENSG00000184922
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.04
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.03
    Ensembl ID: ENSG00000060971
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004455
Hovered Details

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Hovered Details

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**Key Characteristics** * CD8-positive, alpha-beta T cells * Naive thymus-derived * CD45RA-positive, CCR7-positive, and CD127-positive * CD25-negative * CD62L-high * CD44-low * Lack of antigen exposure and activation * Play a crucial role in the development of the adaptive immune system * Essential for the proper functioning of the immune response **Clinical Significance** Naive thymus-derived CD8-positive, alpha-beta T cells are an essential component of the adaptive immune system. They are responsible for recognizing and eliminating infected cells and tumor cells. Abnormalities in the development or function of these cells can lead to impaired immune responses, making individuals more susceptible to infections and diseases. * Impaired immune responses can lead to increased susceptibility to infections and diseases * Abnormalities in the development or function of naive thymus-derived CD8-positive, alpha-beta T cells can lead to autoimmune diseases and cancer * Understanding the role of these cells in the immune response can lead to the development of new therapeutic strategies for the treatment of immune-related disorders **Pathways and Ontology** Naive thymus-derived CD8-positive, alpha-beta T cells are involved in a wide range of cellular processes, including: * Apoptotic process * ATP:ADP antiporter activity * Disease * HIV infection * Host interactions of HIV factors * Infectious disease * Influenza infection * Influenza virus-induced apoptosis * Interactions of Vpr with host cellular proteins * Membrane * Metabolism of proteins * Mitochondrial ATP transmembrane transport * Mitochondrial inner membrane * Mitochondrial protein degradation * Mitochondrial protein import * Mitochondrion * Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway * Nucleus * Protein binding * Protein localization * SLC-mediated transmembrane transport * Tim23 mitochondrial import inner membrane translocase complex * Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane * Transport of small molecules * Transport of vitamins, nucleosides, and related molecules * Viral infection pathways * Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization These pathways and ontology highlight the complex role of naive thymus-derived CD8-positive, alpha-beta T cells in the immune response and their involvement in a wide range of cellular processes. **Genes** The genes involved in the function of naive thymus-derived CD8-positive, alpha-beta T cells include: * ACTB (actin beta) * BTF3 (nascent polypeptide-associated complex beta 3 subunit) * ATP5F1E (mitochondrial ATP synthase F1 subunit alpha) * ATP5MC2 (mitochondrial ATP synthase gamma/c subunit) These genes play critical roles in the function of the immune system and are involved in a wide range of cellular processes. **Diseases** Naive thymus-derived CD8-positive, alpha-beta T cells are involved in the development of various diseases, including: * Autoimmune diseases * Cancer * Infectious diseases * Inflammatory diseases Understanding the role of these cells in the immune response can lead to the development of new therapeutic strategies for the treatment of immune-related disorders.