Details for: CL0000903

Cell ID: CL0000903

Cell Name: natural T-regulatory cell

Marker Score Threshold: 514
(Derived using integrated single-cell and genomic data)

Description: CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function.

Synonyms: nTreg, natural Treg, natural regulatory T cell, natural regulatory T lymphocyte, natural regulatory T-cell, natural regulatory T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 5.62
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.83
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 4.81
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.55
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 4.17
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 4.12
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.99
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.97
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.87
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.74
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.72
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 3.63
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.6
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.46
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.34
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.3
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.11
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 3.07
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.97
    Ensembl ID: ENSG00000160654
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.92
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.92
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.88
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.82
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.7
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.67
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.63
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.53
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.47
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.38
    Ensembl ID: ENSG00000132965
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.29
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.27
    Ensembl ID: ENSG00000143119
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.25
    Ensembl ID: ENSG00000067560
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 2.22
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.1
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.08
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.02
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.98
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.94
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.94
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.94
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.89
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.87
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.85
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.79
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.75
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.73
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 1.72
    Ensembl ID: ENSG00000153563
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.72
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.71
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.7
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.69
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.65
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.65
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.55
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.54
    Ensembl ID: ENSG00000123146
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.52
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.52
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.5
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.44
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.42
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.42
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.38
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 1.34
    Ensembl ID: ENSG00000172116
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.34
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.32
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.31
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.31
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.25
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.25
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.22
    Ensembl ID: ENSG00000112297
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.21
    Ensembl ID: ENSG00000118971
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.21
    Ensembl ID: ENSG00000184922
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.21
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.21
    Ensembl ID: ENSG00000111276
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.2
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196776
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168675
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.19
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.18
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.17
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.17
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.16
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.15
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 1.14
    Ensembl ID: ENSG00000013725
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.13
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.12
    Ensembl ID: ENSG00000117410
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.12
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.09
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.04
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.02
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.02
    Ensembl ID: ENSG00000168374
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.02
    Ensembl ID: ENSG00000198898
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Phenotype**: NTregs are characterized by their expression of FoxP3, CD25, CD62L, and CTLA-4. FoxP3 is a transcription factor that is essential for the development and function of NTregs. CD25 is a high-affinity interleukin-2 receptor alpha subunit that is involved in the activation of NTregs. CD62L is a leukocyte cell adhesion molecule that is involved in the migration of NTregs to tissues. CTLA-4 is a protein that is expressed on the surface of NTregs and is involved in their inhibition of T-cell activation. 2. **Regulatory Function**: NTregs are involved in the regulation of immune responses, including the suppression of T-cell activation, the promotion of tolerance, and the prevention of autoimmune disease. They do this by producing anti-inflammatory cytokines, such as TGF-β and IL-10, and by inhibiting the activity of other immune cells, such as dendritic cells and macrophages. 3. **Antigen Presentation**: NTregs are involved in the presentation of antigens to T-cells, including the presentation of endogenous peptides via MHC class I and the presentation of exogenous peptides via MHC class II. 4. **Cytokine Signaling**: NTregs are involved in the production and regulation of various cytokines, including TGF-β, IL-10, and IL-12. These cytokines play important roles in regulating immune responses and maintaining immune tolerance. 5. **Immunoregulatory Interactions**: NTregs interact with other immune cells, including dendritic cells, macrophages, and B-cells, to regulate immune responses and maintain immune tolerance. **Clinical Significance** 1. **Autoimmune Disease**: NTregs play a crucial role in preventing autoimmune disease by regulating the activity of other immune cells. Dysregulation of NTregs has been implicated in various autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. 2. **Transplantation**: NTregs are involved in the regulation of immune responses to transplanted organs. They play a crucial role in preventing graft rejection and maintaining immune tolerance. 3. **Infectious Disease**: NTregs are involved in the regulation of immune responses to infectious diseases, including the suppression of T-cell activation and the promotion of tolerance. 4. **Cancer**: NTregs are involved in the regulation of immune responses to cancer. They play a crucial role in preventing tumor immune evasion and promoting tumor cell death. 5. **Immunotherapy**: NTregs are being explored as a potential target for immunotherapy in various diseases, including cancer and autoimmune disease. Modulating the activity of NTregs may provide a novel approach to treating these diseases.