CL0000907 - central memory CD8-positive, alpha-beta T cell details

Details for: CL0000907

Cell ID: CL0000907

Cell Name: central memory CD8-positive, alpha-beta T cell

Marker Score Threshold: 2439
(Derived using integrated single-cell and genomic data)

Description: CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.

Synonyms: central memory CD8+ T cell, central CD8-positive, alpha-beta memory T cell, central CD8-positive, alpha-beta memory T lymphocyte, central CD8-positive, alpha-beta memory T-cell, central CD8-positive, alpha-beta memory T-lymphocyte, central memory CD8-positive, alpha-beta T lymphocyte, central memory CD8-positive, alpha-beta T-cell, central memory CD8-positive, alpha-beta T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 4.13
Ensembl ID: ENSG00000075624
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 3.99
Ensembl ID: ENSG00000133639
Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 3.93
Ensembl ID: ENSG00000111348
Gene Symbol: CFL1 (ENSG00000172757)
Fold Change: 3.87
Ensembl ID: ENSG00000172757
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 3.78
Ensembl ID: ENSG00000145741
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 3.6
Ensembl ID: ENSG00000124172
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 3.49
Ensembl ID: ENSG00000135390
Gene Symbol: CDC42 (ENSG00000070831)
Fold Change: 3.43
Ensembl ID: ENSG00000070831
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 3.3
Ensembl ID: ENSG00000067560
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 3.26
Ensembl ID: ENSG00000104964
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 3.26
Ensembl ID: ENSG00000169100
Gene Symbol: CCND3 (ENSG00000112576)
Fold Change: 2.93
Ensembl ID: ENSG00000112576
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 2.85
Ensembl ID: ENSG00000149925
Gene Symbol: SEPTIN7 (ENSG00000122545)
Fold Change: 2.83
Ensembl ID: ENSG00000122545
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 2.79
Ensembl ID: ENSG00000198931
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 2.77
Ensembl ID: ENSG00000135046
Gene Symbol: ATP6V0C (ENSG00000185883)
Fold Change: 2.7
Ensembl ID: ENSG00000185883
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 2.66
Ensembl ID: ENSG00000099624
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 2.64
Ensembl ID: ENSG00000143761
Gene Symbol: CAPZB (ENSG00000077549)
Fold Change: 2.55
Ensembl ID: ENSG00000077549
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 2.54
Ensembl ID: ENSG00000179218
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 2.43
Ensembl ID: ENSG00000005022
Gene Symbol: B2M (ENSG00000166710)
Fold Change: 2.37
Ensembl ID: ENSG00000166710
Gene Symbol: CD53 (ENSG00000143119)
Fold Change: 2.36
Ensembl ID: ENSG00000143119
Gene Symbol: ANXA6 (ENSG00000197043)
Fold Change: 2.29
Ensembl ID: ENSG00000197043
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 2.28
Ensembl ID: ENSG00000143933
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 2.28
Ensembl ID: ENSG00000110955
Gene Symbol: CD247 (ENSG00000198821)
Fold Change: 2.23
Ensembl ID: ENSG00000198821
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.22
Ensembl ID: ENSG00000198668
Gene Symbol: RHOH (ENSG00000168421)
Fold Change: 2.21
Ensembl ID: ENSG00000168421
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 2.19
Ensembl ID: ENSG00000154518
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 2.09
Ensembl ID: ENSG00000122359
Gene Symbol: CAMK4 (ENSG00000152495)
Fold Change: 2.08
Ensembl ID: ENSG00000152495
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 2.02
Ensembl ID: ENSG00000184009
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 2.01
Ensembl ID: ENSG00000134825
Gene Symbol: CD48 (ENSG00000117091)
Fold Change: 1.97
Ensembl ID: ENSG00000117091
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.96
Ensembl ID: ENSG00000141522
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 1.96
Ensembl ID: ENSG00000100300
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.95
Ensembl ID: ENSG00000004059
Gene Symbol: ATM (ENSG00000149311)
Fold Change: 1.95
Ensembl ID: ENSG00000149311
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 1.91
Ensembl ID: ENSG00000153113
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 1.89
Ensembl ID: ENSG00000085224
Gene Symbol: CALM3 (ENSG00000160014)
Fold Change: 1.88
Ensembl ID: ENSG00000160014
Gene Symbol: ADD3 (ENSG00000148700)
Fold Change: 1.87
Ensembl ID: ENSG00000148700
Gene Symbol: ARRB2 (ENSG00000141480)
Fold Change: 1.79
Ensembl ID: ENSG00000141480
Gene Symbol: CCNH (ENSG00000134480)
Fold Change: 1.79
Ensembl ID: ENSG00000134480
Gene Symbol: BIN1 (ENSG00000136717)
Fold Change: 1.77
Ensembl ID: ENSG00000136717
Gene Symbol: BST2 (ENSG00000130303)
Fold Change: 1.76
Ensembl ID: ENSG00000130303
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.74
Ensembl ID: ENSG00000172270
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.7
Ensembl ID: ENSG00000154723
Gene Symbol: ADGRE5 (ENSG00000123146)
Fold Change: 1.69
Ensembl ID: ENSG00000123146
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 1.67
Ensembl ID: ENSG00000152518
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.67
Ensembl ID: ENSG00000165629
Gene Symbol: CD74 (ENSG00000019582)
Fold Change: 1.66
Ensembl ID: ENSG00000019582
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.66
Ensembl ID: ENSG00000116459
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 1.63
Ensembl ID: ENSG00000185650
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.61
Ensembl ID: ENSG00000152234
Gene Symbol: CAPN2 (ENSG00000162909)
Fold Change: 1.61
Ensembl ID: ENSG00000162909
Gene Symbol: BAX (ENSG00000087088)
Fold Change: 1.6
Ensembl ID: ENSG00000087088
Gene Symbol: RHOG (ENSG00000177105)
Fold Change: 1.6
Ensembl ID: ENSG00000177105
Gene Symbol: CHD2 (ENSG00000173575)
Fold Change: 1.58
Ensembl ID: ENSG00000173575
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.57
Ensembl ID: ENSG00000115307
Gene Symbol: ARHGAP4 (ENSG00000089820)
Fold Change: 1.55
Ensembl ID: ENSG00000089820
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.53
Ensembl ID: ENSG00000127022
Gene Symbol: C1QBP (ENSG00000108561)
Fold Change: 1.52
Ensembl ID: ENSG00000108561
Gene Symbol: ALOX5AP (ENSG00000132965)
Fold Change: 1.52
Ensembl ID: ENSG00000132965
Gene Symbol: CD6 (ENSG00000013725)
Fold Change: 1.48
Ensembl ID: ENSG00000013725
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.46
Ensembl ID: ENSG00000165527
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.46
Ensembl ID: ENSG00000160710
Gene Symbol: CTSC (ENSG00000109861)
Fold Change: 1.45
Ensembl ID: ENSG00000109861
Gene Symbol: CENPC (ENSG00000145241)
Fold Change: 1.45
Ensembl ID: ENSG00000145241
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.41
Ensembl ID: ENSG00000169020
Gene Symbol: CD5 (ENSG00000110448)
Fold Change: 1.4
Ensembl ID: ENSG00000110448
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.39
Ensembl ID: ENSG00000117410
Gene Symbol: CHD1 (ENSG00000153922)
Fold Change: 1.38
Ensembl ID: ENSG00000153922
Gene Symbol: ACP1 (ENSG00000143727)
Fold Change: 1.37
Ensembl ID: ENSG00000143727
Gene Symbol: CDKN1B (ENSG00000111276)
Fold Change: 1.36
Ensembl ID: ENSG00000111276
Gene Symbol: CDC25B (ENSG00000101224)
Fold Change: 1.33
Ensembl ID: ENSG00000101224
Gene Symbol: FMNL1 (ENSG00000184922)
Fold Change: 1.29
Ensembl ID: ENSG00000184922
Gene Symbol: CBLB (ENSG00000114423)
Fold Change: 1.28
Ensembl ID: ENSG00000114423
Gene Symbol: CCT6A (ENSG00000146731)
Fold Change: 1.22
Ensembl ID: ENSG00000146731
Gene Symbol: BNIP2 (ENSG00000140299)
Fold Change: 1.22
Ensembl ID: ENSG00000140299
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.19
Ensembl ID: ENSG00000164111
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.19
Ensembl ID: ENSG00000163399
Gene Symbol: CD44 (ENSG00000026508)
Fold Change: 1.18
Ensembl ID: ENSG00000026508
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.15
Ensembl ID: ENSG00000168374
Gene Symbol: PARP1 (ENSG00000143799)
Fold Change: 1.14
Ensembl ID: ENSG00000143799
Gene Symbol: CASP8 (ENSG00000064012)
Fold Change: 1.13
Ensembl ID: ENSG00000064012
Gene Symbol: RUNX3 (ENSG00000020633)
Fold Change: 1.09
Ensembl ID: ENSG00000020633
Gene Symbol: CD47 (ENSG00000196776)
Fold Change: 1.08
Ensembl ID: ENSG00000196776
Gene Symbol: CD52 (ENSG00000169442)
Fold Change: 1.08
Ensembl ID: ENSG00000169442
Gene Symbol: CHD3 (ENSG00000170004)
Fold Change: 1.08
Ensembl ID: ENSG00000170004
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.08
Ensembl ID: ENSG00000100823
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 1.07
Ensembl ID: ENSG00000159199
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.06
Ensembl ID: ENSG00000138279
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.05
Ensembl ID: ENSG00000072778
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.05
Ensembl ID: ENSG00000137845
Gene Symbol: CAPZA1 (ENSG00000116489)
Fold Change: 1.04
Ensembl ID: ENSG00000116489
Gene Symbol: ADSL (ENSG00000239900)
Fold Change: 1.03
Ensembl ID: ENSG00000239900
Gene Symbol: BCL2 (ENSG00000171791)
Fold Change: 1
Ensembl ID: ENSG00000171791

Gene representation (1452)
Gene/Pathway representation (1452)

Hovered Details

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Hovered Details

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**Key Characteristics** Central memory CD8-positive, alpha-beta T cells are characterized by their expression of specific surface markers, including: * CCR7: a chemokine receptor that allows these cells to migrate to lymphoid tissues * CD127: a high-affinity IL-7 receptor that is necessary for the maintenance of T cell homeostasis * CD45RA: a low-affinity IL-2 receptor that is expressed on naive T cells * CD45RO: a high-affinity IL-2 receptor that is expressed on memory T cells * CD25: a high-affinity IL-2 receptor that is expressed on activated T cells These cells also express the alpha-beta T cell receptor (TCR) and are capable of recognizing and responding to antigens presented by MHC class I molecules. **Clinical Significance** Central memory CD8-positive, alpha-beta T cells play a crucial role in the adaptive immune response and are involved in the protection against various infections, including: * Viral infections: such as HIV, HBV, and HCV * Bacterial infections: such as tuberculosis and leishmaniasis * Cancer: such as melanoma and lymphoma Dysregulation of central memory CD8-positive, alpha-beta T cells has been implicated in various autoimmune diseases, including: * Multiple sclerosis * Rheumatoid arthritis * Type 1 diabetes Understanding the biology and function of central memory CD8-positive, alpha-beta T cells is essential for the development of novel immunotherapies and vaccines against infectious diseases and cancer. **Pathways and Ontologies** Central memory CD8-positive, alpha-beta T cells are involved in various signaling pathways, including: * Actin cytoskeleton and actin filament organization * Adherens junction assembly and interactions * Apical junction complex and protein localization * ATP binding and axon guidance * Axonogenesis and axon guidance * B-wich complex positively regulates rRNA expression * Bbaf complex * Blood microparticle * Brahma complex * Brush border * Calyx of held * Cell-cell communication * Cell-cell junction * Cell-cell junction organization * Cell-extracellular matrix interactions * Cell junction organization * Cell motility * Cellular response to cytochalasin B * Chaperonin-mediated protein folding * Chromatin * Chromatin modifying enzymes * Chromatin organization * Chromatin remodeling * Clathrin-mediated endocytosis * Cooperation of prefoldin and tric/CCT in actin and tubulin folding * Cortical cytoskeleton * Cytoplasm * Cytoplasmic ribonucleoprotein granule * Cytoskeleton * Cytosol * Dense body * Deubiquitination * Developmental biology * Disease * Diseases of signal transduction by growth factor receptors and second messengers * Dna damage recognition in gg-ner * Dna repair * Eph-ephrin mediated repulsion of cells * Eph-ephrin signaling * Ephb-mediated forward signaling * Epigenetic regulation of gene expression * Establishment or maintenance of cell polarity * Extracellular exosome * Extracellular space * Factors involved in megakaryocyte development and platelet production * Fcgamma receptor (fcgr) dependent phagocytosis * Fcgr3a-mediated phagocytosis * Focal adhesion * Folding of actin by CCT/TRIC * Formation of annular gap junctions * Gap junction degradation * Gap junction trafficking * Gap junction trafficking and regulation * Gbaf complex * Gene expression (transcription) * Global genome nucleotide excision repair (gg-ner) * Glutamatergic synapse * Hats acetylate histones * Hemostasis * Hydrolase activity * Identical protein binding * Immune system * Infectious disease * Innate immune system * Interaction between L1 and ankyrins * Kinesin binding * Kinetochore * L1cam interactions * Lamellipodium * Leishmania infection * Leishmania phagocytosis * Maintenance of blood-brain barrier * Map2k and mapk activation * Mapk1/mapk3 signaling * Mapk family signaling cascades * Membrane * Membrane trafficking * Metabolism of proteins * Morphogenesis of a polarized epithelium * Nbaf complex * Negative regulation of cell differentiation * Negative regulation of protein binding * Nervous system development * Nitric-oxide synthase binding * Npbaf complex * Nua4 histone acetyltransferase complex * Nuclear matrix * Nucleoplasm * Nucleosomal dna binding * Nucleosome * Nucleotide excision repair * Nucleus * Oncogenic mapk signaling * Paradoxical activation of raf signaling by kinase inactive braf * Parasite infection * Parasitic infection pathways * Plasma membrane * Platelet aggregation * Positive epigenetic regulation of rRNA expression * Positive regulation of cell differentiation * Positive regulation of cell population proliferation * Positive regulation of dna-templated transcription * Positive regulation of double-strand break repair * Positive regulation of double-strand break repair via homologous recombination * Positive regulation of myoblast differentiation * Positive regulation of norepinephrine uptake * Positive regulation of stem cell population maintenance * Positive regulation of t cell differentiation * Post-translational protein modification * Postsynaptic actin cytoskeleton * Postsynaptic actin cytoskeleton organization * Prefoldin mediated transfer of substrate to CCT/TRIC * Presynapse * Protein-containing complex * Protein binding * Protein folding * Protein kinase binding * Protein localization to adherens junction * Raf/map kinase cascade * Recycling pathway of L1 * Regulation of actin dynamics for phagocytic cup formation * Regulation of apoptotic process * Regulation of cell cycle * Regulation of cyclin-dependent protein serine/threonine kinase activity * Regulation of double-strand break repair * Regulation of g0 to g1 transition * Regulation of g1/s transition of mitotic cell cycle * Regulation of mitotic metaphase/anaphase transition * Regulation of norepinephrine uptake * Regulation of nucleotide-excision repair * Regulation of protein localization to plasma membrane * Regulation of synaptic vesicle endocytosis * Regulation of transcription by rNA polymerase II * Regulation of transepithelial transport * Regulation of transmembrane transporter activity * Rhof GTPase cycle * Rho GTPase cycle * Rho GTPase effectors * Rho GTPases activate formins * Rho GTPases activate iqgaps * Rho GTPases activate wasps and waves * Ribonucleoprotein complex * Rsc-type complex * Schaffer collateral - ca1 synapse * Sensory perception * Sensory processing of sound * Sensory processing of sound by inner hair cells of the cochlea * Sensory processing of sound by outer hair cells of the cochlea * Signaling by braf and raf1 fusions * Signaling by high-kinase activity braf mutants * Signaling by moderate kinase activity braf mutants * Signaling by raf1 mutants * Signaling by ras mutants * Signaling by receptor tyrosine kinases * Signaling by rho GTPases * Signaling by rho GTPases, miro GTPases and rhobtb3 * Signaling by vegf * Signaling downstream of ras mutants * Signal transduction * Structural constituent of cytoskeleton * Structural constituent of postsynaptic actin cytoskeleton * Substantia nigra development * Swi/Snf complex * Synapse * Tat protein binding * Tau protein binding * Tight junction * Translocation of SLC2A4 (glut4) to the plasma membrane * Uch proteinases * Vegfa-vegfr2 pathway * Vesicle * Vesicle-mediated transport

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.